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This locus represents naturally occurring read-through transcription between the neighboring SLX1A (SLX1 structure-specific endonuclease subunit homolog A) and SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) genes on the short arm of chromosome 16. A duplicate read-through locus also exists between the SLX1B and SULT1A4 genes located approximately 730 kb upstream on the same chromosome. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2017]
SLX1A-SULT1A3 (SLX1A-SULT1A3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J030192 | Promoter/Enhancer | 0.8 | EPDnew Ensembl dbSUPER | 600.7 | -0.1 | -91 | 3.2 | BOLA2B SLX1A SLX1A-SULT1A3 lnc-NPIPB13-1 BOLA2 CORO1A | ||
GH16J030119 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 12.6 | -71.7 | -71721 | 5.8 | HNRNPL GATAD2A TFE3 IKZF1 KDM1A CTCF ZNF692 POLR2A RCOR2 BACH1 | MAPK3 RF00017-2045 YPEL3 SETD1A NPIPB13 NPIPB12 SRCAP ZNF747 INO80E CORO1A | |
GH16J030112 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 12.3 | -79.1 | -79132 | 5.7 | ARHGAP35 CEBPG HNRNPL GATAD2A CTCF ZBTB33 TEAD4 TFE3 IKZF1 NFKBIZ | GDPD3 lnc-PPP4C-12 SLX1A TBX6 SRCAP INO80E SMG1P5 SMG1P2 ENSG00000235560 MAPK3 | |
GH16J030208 | Promoter/Enhancer | 0.8 | EPDnew Ensembl dbSUPER | 0.4 | +5.6 | 5609 | 0.6 | SULT1A3 ENSG00000278887 SLX1A-SULT1A3 NPIPB13 | ||
GH16J030196 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 0.7 | +3.0 | 3009 | 0.6 | BOLA2B SULT1A3 SLX1A SLX1A-SULT1A3 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type | ||
2 | Sulfation Biotransformation Reaction |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075D98B_9606 | lncRNA | 2218 | 1 |
RefSeq: NR_037608, |
URS0000EF5369_9606 | lncRNA | 2195 | 1 |
Ensembl: ENST00000565342 (view in UCSC) , |
URS00009AD331_9606 | lncRNA | 2424 | 1 |
NONCODE: NONHSAT172835.1, |
No disorders were found for SLX1A-SULT1A3 Gene.