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This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]
SLX1A (SLX1 Homolog A, Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with SLX1A include Fanconi Anemia, Complementation Group P and Interstitial Nephritis, Karyomegalic. Among its related pathways are Resolution of D-loop Structures through Holliday Junction Intermediates and Homologous DNA Pairing and Strand Exchange. Gene Ontology (GO) annotations related to this gene include crossover junction endodeoxyribonuclease activity and 5'-flap endonuclease activity. An important paralog of this gene is SLX1B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004518 | nuclease activity | IEA | -- |
GO:0004519 | endonuclease activity | IEA | -- |
GO:0005515 | protein binding | IPI | 19595721 |
GO:0008821 | crossover junction endodeoxyribonuclease activity | IBA,IDA | 19595721 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0033557 | Slx1-Slx4 complex | TAS | 24012755 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | DNA Double-Strand Break Repair |
.53
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2 | Fanconi anemia pathway | ||
3 | Resolution of D-loop Structures through Holliday Junction Intermediates | ||
4 | Homologous DNA Pairing and Strand Exchange |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000724 | double-strand break repair via homologous recombination | IBA,IMP | 19595721 |
GO:0006281 | DNA repair | IMP | 19595721 |
GO:0006310 | DNA recombination | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing | IMP | 19595721 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | SLX1A 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | SLX1A 30 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Slx1b 30 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Slx1b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slx1a 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100001845 30 |
|
||
SLX1A 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002259 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | slx1 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | slx-1 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SLX1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | slx1 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
fanconi anemia, complementation group p |
|
|
interstitial nephritis, karyomegalic |
|
|
xeroderma pigmentosum, complementation group f |
|
|
fanconi anemia, complementation group q |
|
|
xeroderma pigmentosum, variant type |
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|