Aliases for SLX1A Gene
External Ids for SLX1A Gene
Previous HGNC Symbols for SLX1A Gene
Previous GeneCards Identifiers for SLX1A Gene
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for SLX1A Gene
SLX1A (SLX1 Homolog A, Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with SLX1A include Interstitial Nephritis, Karyomegalic and Fanconi Anemia, Complementation Group P. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-loop Structures through Holliday Junction Intermediates. Gene Ontology (GO) annotations related to this gene include crossover junction endodeoxyribonuclease activity and 5'-flap endonuclease activity. An important paralog of this gene is SLX1B.
UniProtKB/Swiss-Prot Summary for SLX1A Gene
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.