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This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplicat... See more...
Aliases for SLX1A Gene
Aliases for SLX1A Gene
External Ids for SLX1A Gene
- HGNC: 20922
- Entrez Gene: 548593
- Ensembl: ENSG00000132207
- OMIM: 615822
- UniProtKB: Q9BQ83
Previous HGNC Symbols for SLX1A Gene
- GIYD1
Previous GeneCards Identifiers for SLX1A Gene
- GC16P030208
- GC16P030210
- GC16P030215
- GC16P030218
- GC16P030196
- GC16P030200
- GC16P030276
- GC16P030281
- GC16P030195
- GC16P030328
- GC16P030222
- GC16P030233
- GC16P030242
- GC16P030247
- GC16P030252
- GC16P030260
- GC16P030265
- GC16P030270
Summaries for SLX1A Gene
-
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for SLX1A Gene
SLX1A (SLX1 Homolog A, Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with SLX1A include Fanconi Anemia, Complementation Group P and Interstitial Nephritis, Karyomegalic. Among its related pathways are Resolution of D-loop Structures through Holliday Junction Intermediates and Homologous DNA Pairing and Strand Exchange. Gene Ontology (GO) annotations related to this gene include crossover junction endodeoxyribonuclease activity and 5'-flap endonuclease activity. An important paralog of this gene is SLX1B.
UniProtKB/Swiss-Prot Summary for SLX1A Gene
-
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
Additional gene information for SLX1A Gene
- HGNC(20922)
- Entrez Gene(548593)
- Ensembl(ENSG00000132207)
- OMIM(615822)
- UniProtKB(Q9BQ83)
- Open Targets Platform(ENSG00000132207)
- Search for SLX1A at DataMed
- Search for SLX1A at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLX1A Gene
Genomics for SLX1A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLX1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLX1A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLX1A
Genomic Locations for SLX1A Gene
Genomic Locations for SLX1A Gene
- chr16:30,193,843-30,197,566
- (GRCh38/hg38)
- Size:
- 3,724 bases
- Orientation:
- Plus strand
- chr16:30,205,164-30,208,887
- (GRCh37/hg19)
- Size:
- 3,724 bases
- Orientation:
- Plus strand
Genomic View for SLX1A Gene
Genes around SLX1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
SLX1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLX1A Gene
Proteins for SLX1A Gene
-
Protein details for SLX1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQ83-SLX1_HUMAN
- Recommended name:
- Structure-specific endonuclease subunit SLX1
- Protein Accession:
- Q9BQ83
- B7ZME1
- Q6NTG6
Protein attributes for SLX1A Gene
- Size:
- 275 amino acids
- Molecular mass:
- 30771 Da
- Cofactor:
- Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Quaternary structure:
-
- Forms a heterodimer with SLX4.
Protein Expression for SLX1A Gene
Post-translational modifications for SLX1A Gene
Other Protein References for SLX1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SLX1A
-
Abcam antibodies for SLX1A
- antibodies-online: Show 4 available SLX1A Antibodies ranked by validation data
- Sino Biological Antibodies for SLX1A
Protein Products
-
OriGene Purified Proteins for SLX1A
- Search Origene for MassSpec and Protein Over-expression Lysates for SLX1A
- Origene Custom Protein Services for SLX1A
- Novus Biologicals proteins for SLX1A
- antibodies-online: Show 2 available SLX1A Proteins ranked by validation data
- Compare Top SLX1A Proteins
-
Quality Products:
-
Abcam proteins for SLX1A
No data available for DME Specific Peptides for SLX1A Gene
Domains & Families for SLX1A Gene
Gene Families for SLX1A Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SLX1A Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
Q9BQ83- Family:
-
- Belongs to the SLX1 family.
No data available for Suggested Antigen Peptide Sequences for SLX1A Gene
Function for SLX1A Gene
Molecular function for SLX1A Gene
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
Enzyme Numbers (IUBMB) for SLX1A Gene
Phenotypes From GWAS Catalog for SLX1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004519 | endonuclease activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 19595721 |
| GO:0008821 | crossover junction endodeoxyribonuclease activity | IBA,IDA | 19595721 |
| GO:0016787 | hydrolase activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLX1A - Select products 50% OFF >
- * SLX1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for SLX1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLX1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLX1A
miRNA for SLX1A Gene
- miRTarBase miRNAs that target SLX1A
-
- mmu-miR-466o-3p (MIRT585810)
- mmu-miR-466m-3p (MIRT585811)
- mmu-miR-466f-3p (MIRT585812)
- mmu-miR-362-3p (MIRT585813)
- mmu-miR-466i-3p (MIRT585814)
- mmu-miR-329-3p (MIRT585815)
- mmu-miR-1896 (MIRT601594)
- mmu-miR-129-1-3p (MIRT601595)
- mmu-miR-129-2-3p (MIRT601596)
- mmu-miR-3085-3p (MIRT601597)
- mmu-miR-3064-5p (MIRT601598)
- mmu-miR-28b (MIRT601599)
- mmu-miR-5133 (MIRT601600)
- mmu-miR-28c (MIRT601601)
- mmu-miR-3470a (MIRT601602)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLX1A
- Browse OriGene Inhibitory RNA Products For SLX1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLX1A
Clone Products
- Applied Biological Materials (abm): Clones for SLX1A - Select products 50% OFF >
- * SLX1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for SLX1A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLX1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLX1A
Cell Line Products
-
Horizon Cell Lines for SLX1A
No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLX1A Gene
Localization for SLX1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLX1A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0033557 | Slx1-Slx4 complex | TAS | 24012755 |
Pathways & Interactions for SLX1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Double-Strand Break Repair |
.53
|
|
| 2 | Fanconi anemia pathway | ||
| 3 | Resolution of D-loop Structures through Holliday Junction Intermediates | ||
| 4 | Homologous DNA Pairing and Strand Exchange | ||
Pathways by source for SLX1A Gene
1 KEGG pathway for SLX1A Gene
Interacting Proteins for SLX1A Gene
Selected Interacting proteins:
Q9BQ83-SLX1_HUMAN
ENSP00000251303
for SLX1A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SLX1A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000724 | double-strand break repair via homologous recombination | IBA,IMP | 19595721 |
| GO:0006281 | DNA repair | IMP | 19595721 |
| GO:0006310 | DNA recombination | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing | IMP | 19595721 |
No data available for SIGNOR curated interactions for SLX1A Gene
Transcripts for SLX1A Gene
mRNA/cDNA for SLX1A Gene
- 2 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000251303 1133 nts (view in UCSC)
- ENST00000345535 762 nts (view in UCSC)
- ENST00000563616 578 nts (view in UCSC)
- ENST00000563995 589 nts (view in UCSC)
- ENST00000564268 1140 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLX1A - Select products 50% OFF >
- * SLX1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLX1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLX1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLX1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLX1A
- Browse OriGene Inhibitory RNA Products For SLX1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLX1A
Clone Products
- Applied Biological Materials (abm): Clones for SLX1A - Select products 50% OFF >
- * SLX1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for SLX1A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLX1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLX1A
Relevant External Links for SLX1A Gene
- GeneLoc Exon Structure for
- SLX1A
Expression for SLX1A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLX1A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLX1A
SOURCE GeneReport for Unigene cluster for SLX1A Gene:
Hs.729791Evidence on tissue expression from TISSUES for SLX1A Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for SLX1A
-
OriGene qPCR primer pairs and template standards for SLX1A
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLX1A Gene
Orthologs for SLX1A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | SLX1A 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | SLX1A 30 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Slx1b 30 31 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Slx1b 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slx1a 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100001845 30 |
|
||
| SLX1A 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002259 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | slx1 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | slx-1 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SLX1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | slx1 30 |
|
- Species where no ortholog for SLX1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLX1A Gene
- ENSEMBL:
- Gene Tree for SLX1A (if available)
- TreeFam:
- Gene Tree for SLX1A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLX1A: view image
Paralogs for SLX1A Gene
(2) SIMAP similar genes for SLX1A Gene using alignment to 2 proteins:
- SLX1_HUMAN
- H3BPC3_HUMAN
Pseudogenes.org Pseudogenes for SLX1A Gene
Variants for SLX1A Gene
Gene Damage Index Score:
2.07;
37.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLX1A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLX1A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLX1A Gene
Disorders for SLX1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi anemia, complementation group p |
|
|
| interstitial nephritis, karyomegalic |
|
|
| xeroderma pigmentosum, complementation group f |
|
|
| fanconi anemia, complementation group q |
|
|
| xeroderma pigmentosum, variant type |
|
|
Search SLX1A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLX1A
No data available for UniProtKB/Swiss-Prot and Genatlas for SLX1A Gene
Publications for SLX1A Gene
- Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. (PMID: 19595721) Muñoz IM … Rouse J (Molecular cell 2009) 2 3 4
- Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. (PMID: 15358107) Hildebrandt MA … Weinshilboum RM (Biochemical and biophysical research communications 2004) 2 3 4
- Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PMID: 19596235) Svendsen JM … Harper JW (Cell 2009) 3 4
- Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. (PMID: 19596236) Fekairi S … Gaillard PHL (Cell 2009) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for SLX1A Gene
- Browse OriGene Antibodies
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- Custom Assay Services
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- OriGene qPCR primer pairs for SLX1A
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for SLX1A
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SLX1A
- Novus Biologicals proteins for SLX1A
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SLX1A
- Abcam proteins for SLX1A
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
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- VectorBuilder Custom and pre-made DNA vectors for SLX1A (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for SLX1A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SLX1A
- antibodies-online: Show 4 available SLX1A Antibodies ranked by validation data
- antibodies-online: Search results for available SLX1A related products ranked by validation data
- antibodies-online: Show 2 available SLX1A Proteins ranked by validation data
- Compare Top SLX1A Proteins
- Quality Products:
- Horizon Cell Lines for SLX1A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLX1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLX1A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SLX1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLX1A
Sources for SLX1A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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