Aliases for SLURP1 Gene
External Ids for SLURP1 Gene
Previous GeneCards Identifiers for SLURP1 Gene
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLURP1 Gene
SLURP1 (Secreted LY6/PLAUR Domain Containing 1) is a Protein Coding gene. Diseases associated with SLURP1 include Mal De Meleda and Palmoplantar Keratoderma, Norrbotten Recessive Type. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is LYPD2.
UniProtKB/Swiss-Prot Summary for SLURP1 Gene
Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).