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SLK (STE20 Like Kinase) is a Protein Coding gene. Diseases associated with SLK include Advanced Sleep Phase Syndrome, Familial, 3 and Advanced Sleep Phase Syndrome, Familial, 1. Among its related pathways are Oocyte meiosis and Adhesion. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 18239682 |
GO:0005515 | protein binding | IPI | 25882817 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA,IDA | 18287541 |
GO:0031252 | cell leading edge | ISS | -- |
GO:0048471 | perinuclear region of cytoplasm | IDA | 26094769 |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Adhesion |
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2 | Apoptosis and Autophagy | ||
3 | DNA Damage | ||
4 | Oocyte meiosis |
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5 | Mitotic Roles of Polo Like Kinases |
Mitotic Roles of Polo Like Kinases
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007346 | regulation of mitotic cell cycle | IBA | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0023014 | signal transduction by protein phosphorylation | IBA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile | Experimental | Pharma | Target | 0 | ||
K-00546 | Experimental | Pharma | Target | 0 | ||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
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ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLK 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLK 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Slk 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slk 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SLK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLK 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | slka 30 31 |
|
OneToMany | |
slkb 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4527 32 |
|
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|
slik 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | C04A11.3 32 |
|
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|
gck-4 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8272 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14840 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
770591 | Likely Benign: not provided | 103,992,590(+) | G/T | INTRON_VARIANT | |
782292 | Benign: not provided | 104,003,514(+) | C/T | MISSENSE_VARIANT | |
801367 | Likely Pathogenic: not provided | 104,019,845(+) | C/T | NONSENSE | |
916392 | Uncertain Significance: not provided | 104,003,344(+) | TAAAG/T | FRAMESHIFT_VARIANT | |
rs190220654 | An ovarian serous carcinoma sample | p.Glu604Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv488e59 | CNV | tandem duplication | 20981092 |
dgv967n100 | CNV | loss | 25217958 |
esv3376056 | CNV | duplication | 20981092 |
esv3413324 | CNV | insertion | 20981092 |
esv3579098 | CNV | loss | 25503493 |
esv3624424 | CNV | loss | 21293372 |
nsv1118186 | CNV | deletion | 24896259 |
nsv1125510 | CNV | tandem duplication | 24896259 |
nsv7532 | CNV | insertion | 18451855 |
nsv951008 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
advanced sleep phase syndrome, familial, 3 |
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advanced sleep phase syndrome, familial, 1 |
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autoimmune glomerulonephritis |
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