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Aliases for SLITRK4 Gene

Aliases for SLITRK4 Gene

  • SLIT And NTRK Like Family Member 4 2 3 5
  • SLIT And NTRK-Like Family, Member 4 2
  • SLIT And NTRK-Like Protein 4 3
  • Slit And Trk Like Gene 4 3

External Ids for SLITRK4 Gene

Previous GeneCards Identifiers for SLITRK4 Gene

  • GC0XM141409
  • GC0XM142441
  • GC0XM142543
  • GC0XM142715
  • GC0XM131814

Summaries for SLITRK4 Gene

Entrez Gene Summary for SLITRK4 Gene

  • This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for SLITRK4 Gene

SLITRK4 (SLIT And NTRK Like Family Member 4) is a Protein Coding gene. Diseases associated with SLITRK4 include Supratentorial Primitive Neuroectodermal Tumor and Supratentorial Cancer. An important paralog of this gene is SLITRK5.

UniProtKB/Swiss-Prot for SLITRK4 Gene

  • It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity).

Additional gene information for SLITRK4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK4 Gene

Genomics for SLITRK4 Gene

GeneHancer (GH) Regulatory Elements for SLITRK4 Gene

Promoters and enhancers for SLITRK4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ143633 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 658.7 +1.1 1124 3.6 E2F1 SP1 MXI1 TARDBP GABPA SLITRK4 MYCLP3
GH0XJ143579 Enhancer 0.4 Ensembl ENCODE 26.7 +55.9 55891 1.7 SLITRK4 MYCLP3 SPANXN3
GH0XJ143632 Enhancer 0.5 ENCODE 0.7 +3.2 3237 0 PKNOX1 ATF7 RUNX3 ATF2 CREM SLITRK4 MYCLP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLITRK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLITRK4 gene promoter:

Genomic Locations for SLITRK4 Gene

Genomic Locations for SLITRK4 Gene
13,318 bases
Minus strand

Genomic View for SLITRK4 Gene

Genes around SLITRK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLITRK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLITRK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK4 Gene

Proteins for SLITRK4 Gene

  • Protein details for SLITRK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT and NTRK-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q5JXG3
    • Q8TCM8
    • Q96DL3

    Protein attributes for SLITRK4 Gene

    837 amino acids
    Molecular mass:
    94331 Da
    Quaternary structure:
    • Interacts (via LRR 1 and 2 repeats) with PTPRD (via extracellular domain).
    • Sequence=BAB71535.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLITRK4 Gene

Post-translational modifications for SLITRK4 Gene

  • Glycosylation at posLast=325325, posLast=307307, and isoforms=81
  • Modification sites at PhosphoSitePlus

Other Protein References for SLITRK4 Gene

No data available for DME Specific Peptides for SLITRK4 Gene

Domains & Families for SLITRK4 Gene

Gene Families for SLITRK4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SLITRK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLITRK family.
  • Belongs to the SLITRK family.
genes like me logo Genes that share domains with SLITRK4: view

Function for SLITRK4 Gene

Molecular function for SLITRK4 Gene

UniProtKB/Swiss-Prot Function:
It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity).

Phenotypes From GWAS Catalog for SLITRK4 Gene

genes like me logo Genes that share phenotypes with SLITRK4: view

Animal Models for SLITRK4 Gene

MGI Knock Outs for SLITRK4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLITRK4 Gene

Localization for SLITRK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK4 Gene

Membrane; Single-pass type I membrane protein. Cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLITRK4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLITRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLITRK4: view

Pathways & Interactions for SLITRK4 Gene

SuperPathways for SLITRK4 Gene

No Data Available

Interacting Proteins for SLITRK4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: Q8IW52-SLIK4_HUMAN ENSP00000336627 for SLITRK4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLITRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IBA,IEA --
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with SLITRK4: view

No data available for Pathways by source and SIGNOR curated interactions for SLITRK4 Gene

Drugs & Compounds for SLITRK4 Gene

No Compound Related Data Available

Transcripts for SLITRK4 Gene

mRNA/cDNA for SLITRK4 Gene

(14) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK4 Gene

SLIT and NTRK-like family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK4 Gene

No ASD Table

Relevant External Links for SLITRK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLITRK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLITRK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9), Brain - Frontal Cortex (BA9) (x4.5), Muscle - Skeletal (x4.4), Adrenal Gland (x4.3), and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for SLITRK4 Gene

This gene is overexpressed in Plasma (22.7), Heart (13.5), Peripheral blood mononuclear cells (11.8), and Adrenal (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLITRK4 Gene

Protein tissue co-expression partners for SLITRK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLITRK4 Gene:


SOURCE GeneReport for Unigene cluster for SLITRK4 Gene:


mRNA Expression by UniProt/SwissProt for SLITRK4 Gene:

Tissue specificity: Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors.

Evidence on tissue expression from TISSUES for SLITRK4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLITRK4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLITRK4 Gene

Orthologs for SLITRK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLITRK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLITRK4 34 33
  • 98.02 (n)
(Canis familiaris)
Mammalia SLITRK4 34 33
  • 91.84 (n)
(Rattus norvegicus)
Mammalia Slitrk4 33
  • 91.35 (n)
(Mus musculus)
Mammalia Slitrk4 16 34 33
  • 90.96 (n)
(Bos Taurus)
Mammalia SLITRK4 34 33
  • 90.71 (n)
(Ornithorhynchus anatinus)
Mammalia SLITRK4 34
  • 90 (a)
(Monodelphis domestica)
Mammalia SLITRK4 34
  • 89 (a)
(Gallus gallus)
Aves SLITRK4 34 33
  • 81.24 (n)
(Anolis carolinensis)
Reptilia SLITRK4 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk4 33
  • 75.52 (n)
(Danio rerio)
Actinopterygii SLITRK4 34
  • 74 (a)
slitrk4 33
  • 68.96 (n)
Species where no ortholog for SLITRK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLITRK4 Gene

Gene Tree for SLITRK4 (if available)
Gene Tree for SLITRK4 (if available)
Evolutionary constrained regions (ECRs) for SLITRK4: view image

Paralogs for SLITRK4 Gene

Paralogs for SLITRK4 Gene

(7) SIMAP similar genes for SLITRK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLITRK4: view

Variants for SLITRK4 Gene

Sequence variations from dbSNP and Humsavar for SLITRK4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000113808 -- 143,625,200(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000555977 -- 143,625,749(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000885522 -- 143,633,887(-) C/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000978305 -- 143,633,672(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001129919 -- 143,623,182(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLITRK4 Gene

Variant ID Type Subtype PubMed ID
dgv1403e199 CNV deletion 23128226
esv2740547 CNV deletion 23290073

Variation tolerance for SLITRK4 Gene

Residual Variation Intolerance Score: 7.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLITRK4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLITRK4 Gene

Disorders for SLITRK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLITRK4 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
supratentorial primitive neuroectodermal tumor
  • ewings sarcoma-primitive neuroectodermal tumor
supratentorial cancer
  • brain neoplasm, supratentorial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLITRK4

genes like me logo Genes that share disorders with SLITRK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLITRK4 Gene

Publications for SLITRK4 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J … Mikoshiba K (Gene 2003) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation. (PMID: 27812321) Kang H … Um JW (Frontiers in molecular neuroscience 2016) 4 58

Products for SLITRK4 Gene

Sources for SLITRK4 Gene

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