Aliases for SLIT1 Gene
External Ids for SLIT1 Gene
Previous HGNC Symbols for SLIT1 Gene
Previous GeneCards Identifiers for SLIT1 Gene
GeneCards Summary for SLIT1 Gene
SLIT1 (Slit Guidance Ligand 1) is a Protein Coding gene. Diseases associated with SLIT1 include Diaphragm Disease and Diaphragmatic Hernia, Congenital. Among its related pathways are Signaling by Slit and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and Roundabout binding. An important paralog of this gene is SLIT2.
UniProtKB/Swiss-Prot Summary for SLIT1 Gene
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.