Aliases for SLFNL1 Gene

Aliases for SLFNL1 Gene

  • Schlafen Like 1 2 3 5
  • Schlafen-Like Protein 1 3 4
  • Testicular Tissue Protein Li 173 3
  • Schlafen-Like 1 2

External Ids for SLFNL1 Gene

Previous GeneCards Identifiers for SLFNL1 Gene

  • GC01M041253
  • GC01M041481
  • GC01M039598

Summaries for SLFNL1 Gene

GeneCards Summary for SLFNL1 Gene

SLFNL1 (Schlafen Like 1) is a Protein Coding gene. An important paralog of this gene is SLFN11.

Additional gene information for SLFNL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLFNL1 Gene

Genomics for SLFNL1 Gene

GeneHancer (GH) Regulatory Elements for SLFNL1 Gene

Promoters and enhancers for SLFNL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLFNL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLFNL1

Top Transcription factor binding sites by QIAGEN in the SLFNL1 gene promoter:
  • CREB
  • deltaCREB
  • E47
  • FOXO4
  • Lmo2
  • MIF-1
  • Nkx2-5
  • Pax-4a
  • Pax-5

Genomic Locations for SLFNL1 Gene

Genomic Locations for SLFNL1 Gene
chr1:41,015,597-41,023,444
(GRCh38/hg38)
Size:
7,848 bases
Orientation:
Minus strand
chr1:41,481,269-41,488,909
(GRCh37/hg19)
Size:
7,641 bases
Orientation:
Minus strand

Genomic View for SLFNL1 Gene

Genes around SLFNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFNL1 Gene

Proteins for SLFNL1 Gene

  • Protein details for SLFNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q499Z3-SLNL1_HUMAN
    Recommended name:
    Schlafen-like protein 1
    Protein Accession:
    Q499Z3
    Secondary Accessions:
    • A8K8D1
    • Q49AG8
    • Q5VW72
    • Q5VW74
    • Q8N7V7
    • Q8TCH6
    • Q8WVZ8

    Protein attributes for SLFNL1 Gene

    Size:
    407 amino acids
    Molecular mass:
    45603 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLFNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLFNL1 Gene

Post-translational modifications for SLFNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFNL1 Gene

Domains & Families for SLFNL1 Gene

Gene Families for SLFNL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLFNL1 Gene

Suggested Antigen Peptide Sequences for SLFNL1 Gene

GenScript: Design optimal peptide antigens:
  • Schlafen-like protein 1 (SLNL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q499Z3

UniProtKB/Swiss-Prot:

SLNL1_HUMAN :
  • Belongs to the Schlafen family. Subgroup I subfamily.
Family:
  • Belongs to the Schlafen family. Subgroup I subfamily.
genes like me logo Genes that share domains with SLFNL1: view

Function for SLFNL1 Gene

Phenotypes From GWAS Catalog for SLFNL1 Gene

Gene Ontology (GO) - Molecular Function for SLFNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFNL1: view
genes like me logo Genes that share phenotypes with SLFNL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLFNL1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLFNL1 Gene

Localization for SLFNL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFNL1 gene
Compartment Confidence
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLFNL1 Gene

Pathways & Interactions for SLFNL1 Gene

PathCards logo

SuperPathways for SLFNL1 Gene

No Data Available

Interacting Proteins for SLFNL1 Gene

Selected Interacting proteins: Q499Z3-SLNL1_HUMAN for SLFNL1 Gene via IID

Symbol External ID(s) Details
APP
;

Gene Ontology (GO) - Biological Process for SLFNL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFNL1 Gene

Drugs & Compounds for SLFNL1 Gene

No Compound Related Data Available

Transcripts for SLFNL1 Gene

mRNA/cDNA for SLFNL1 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLFNL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFNL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2:
SP3:
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: -

Relevant External Links for SLFNL1 Gene

GeneLoc Exon Structure for
SLFNL1

Expression for SLFNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLFNL1 Gene

mRNA differential expression in normal tissues according to GTEx for SLFNL1 Gene

This gene is overexpressed in Testis (x27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFNL1 Gene



Protein tissue co-expression partners for SLFNL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLFNL1

SOURCE GeneReport for Unigene cluster for SLFNL1 Gene:

Hs.194609

Evidence on tissue expression from TISSUES for SLFNL1 Gene

  • Nervous system(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with SLFNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFNL1 Gene

Orthologs for SLFNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLFNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFNL1 31 30
  • 99.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLFNL1 31 30
  • 79.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLFNL1 31 30
  • 78.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slfnl1 17 31 30
  • 78.16 (n)
rat
(Rattus norvegicus)
Mammalia Slfnl1 30
  • 77.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLFNL1 31
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLFNL1 31
  • 49 (a)
OneToOne
Species where no ortholog for SLFNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFNL1 Gene

ENSEMBL:
Gene Tree for SLFNL1 (if available)
TreeFam:
Gene Tree for SLFNL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLFNL1: view image

Paralogs for SLFNL1 Gene

Paralogs for SLFNL1 Gene

genes like me logo Genes that share paralogs with SLFNL1: view

Variants for SLFNL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLFNL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1138293 - p.Ala30Thr
rs17851964 - p.Arg128Ser
rs3738368 - p.Arg144Thr

Additional dbSNP identifiers (rs#s) for SLFNL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLFNL1 Gene

Variant ID Type Subtype PubMed ID
nsv546103 CNV loss 21841781

Variation tolerance for SLFNL1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLFNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFNL1 Gene

Disorders for SLFNL1 Gene

Additional Disease Information for SLFNL1

No disorders were found for SLFNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFNL1 Gene

Publications for SLFNL1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for SLFNL1 Gene

Sources for SLFNL1 Gene