Aliases for SLFN5 Gene

Aliases for SLFN5 Gene

  • Schlafen Family Member 5 2 3 4 5
  • MGC19764 2
  • SLFN5 5

External Ids for SLFN5 Gene

Previous GeneCards Identifiers for SLFN5 Gene

  • GC17U900473
  • GC17M030826
  • GC17P030595
  • GC17P033570
  • GC17P029754

Summaries for SLFN5 Gene

GeneCards Summary for SLFN5 Gene

SLFN5 (Schlafen Family Member 5) is a Protein Coding gene. An important paralog of this gene is SLFN11.

UniProtKB/Swiss-Prot Summary for SLFN5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLFN5 Gene

Genomics for SLFN5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLFN5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLFN5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLFN5

Genomic Locations for SLFN5 Gene

Latest Assembly
30,585 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
30,584 bases
Plus strand

(GRCh37/hg19 by Ensembl)
30,620 bases
Plus strand

Genomic View for SLFN5 Gene

Genes around SLFN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN5 Gene

Proteins for SLFN5 Gene

  • Protein details for SLFN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 5
    Protein Accession:
    Secondary Accessions:
    • Q08AF2
    • Q8WU54
    • Q96A82

    Protein attributes for SLFN5 Gene

    891 amino acids
    Molecular mass:
    101055 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLFN5 Gene

    Alternative splice isoforms for SLFN5 Gene


neXtProt entry for SLFN5 Gene

Post-translational modifications for SLFN5 Gene

  • Ubiquitination at Lys65, Lys138, and Lys584
  • Modification sites at PhosphoSitePlus

Other Protein References for SLFN5 Gene

No data available for DME Specific Peptides for SLFN5 Gene

Domains & Families for SLFN5 Gene

Gene Families for SLFN5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SLFN5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52101 (B4E128_HUMAN)
  • Schlafen family member 5 (SLFN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family. Subgroup III subfamily.
  • Belongs to the Schlafen family. Subgroup III subfamily.
genes like me logo Genes that share domains with SLFN5: view

Function for SLFN5 Gene

Molecular function for SLFN5 Gene

UniProtKB/Swiss-Prot Function:
May have a role in hematopoietic cell differentiation.

Phenotypes From GWAS Catalog for SLFN5 Gene

Gene Ontology (GO) - Molecular Function for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN5: view
genes like me logo Genes that share phenotypes with SLFN5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLFN5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN5 Gene

Localization for SLFN5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN5 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SLFN5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SLFN5 Gene

Pathways & Interactions for SLFN5 Gene

PathCards logo

SuperPathways for SLFN5 Gene

No Data Available

Interacting Proteins for SLFN5 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000299977 Q08AF3-SLFN5_HUMAN for SLFN5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SLFN5: view

No data available for Pathways by source and SIGNOR curated interactions for SLFN5 Gene

Drugs & Compounds for SLFN5 Gene

No Compound Related Data Available

Transcripts for SLFN5 Gene

mRNA/cDNA for SLFN5 Gene

14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLFN5

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN5 Gene

No ASD Table

Relevant External Links for SLFN5 Gene

GeneLoc Exon Structure for

Expression for SLFN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLFN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLFN5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for SLFN5 Gene

This gene is overexpressed in Lymph node (19.0), Peripheral blood mononuclear cells (10.9), Tlymphocyte (10.8), CD8 Tcells (7.7), and CD4 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLFN5 Gene

Protein tissue co-expression partners for SLFN5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLFN5

SOURCE GeneReport for Unigene cluster for SLFN5 Gene:


Evidence on tissue expression from TISSUES for SLFN5 Gene

  • Spleen(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SLFN5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN5 Gene

Orthologs for SLFN5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLFN5 29 30
  • 99.33 (n)
(Canis familiaris)
Mammalia SLFN5 29
  • 80.4 (n)
(Mus musculus)
Mammalia Slfn5 29 16 30
  • 73 (n)
(Rattus norvegicus)
Mammalia Slfn5 29
  • 71.55 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 50 (a)
Species where no ortholog for SLFN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLFN5 Gene

Gene Tree for SLFN5 (if available)
Gene Tree for SLFN5 (if available)
Evolutionary constrained regions (ECRs) for SLFN5: view image
Alliance of Genome Resources:
Additional Orthologs for SLFN5

Paralogs for SLFN5 Gene

Paralogs for SLFN5 Gene

(6) SIMAP similar genes for SLFN5 Gene using alignment to 2 proteins:

  • B4E128_HUMAN
genes like me logo Genes that share paralogs with SLFN5: view

Variants for SLFN5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLFN5 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs114439106 Benign: not provided 35,259,519(+) G/A
NM_144975.4(SLFN5):c.829G>A (p.Val277Ile)
rs116066814 Benign: not provided 35,265,319(+) T/C
NM_144975.4(SLFN5):c.2107T>C (p.Tyr703His)
rs73278963 Benign: not provided 35,258,866(+) A/G
NM_144975.4(SLFN5):c.176A>G (p.Lys59Arg)
rs9905150 Benign: not provided 35,259,709(+) G/A
rs11651240 -- p.Pro787Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLFN5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLFN5 Gene

Variant ID Type Subtype PubMed ID
esv2422399 CNV deletion 17116639
esv3640444 CNV loss 21293372
esv3892998 CNV loss 25118596
esv3892999 CNV loss 25118596
nsv1127565 CNV deletion 24896259
nsv574741 CNV loss 21841781

Variation tolerance for SLFN5 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.55; 91.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLFN5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN5 Gene

Disorders for SLFN5 Gene

Additional Disease Information for SLFN5

No disorders were found for SLFN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN5 Gene

Publications for SLFN5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz DA … Hedrick SM (Immunity 1998) 2 3
  4. Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription. (PMID: 32488136) Wan G … Lu C (British journal of cancer 2020) 3
  5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3

Products for SLFN5 Gene

Sources for SLFN5 Gene