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Aliases for SLFN13 Gene

Aliases for SLFN13 Gene

  • Schlafen Family Member 13 2 3 5
  • SLFN10 3

External Ids for SLFN13 Gene

Previous GeneCards Identifiers for SLFN13 Gene

  • GC17M030786
  • GC17M033762
  • GC17M029947

Summaries for SLFN13 Gene

GeneCards Summary for SLFN13 Gene

SLFN13 (Schlafen Family Member 13) is a Protein Coding gene. An important paralog of this gene is SLFN11.

Additional gene information for SLFN13 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN13 Gene

Genomics for SLFN13 Gene

GeneHancer (GH) Regulatory Elements for SLFN13 Gene

Promoters and enhancers for SLFN13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I035447 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 568.3 +0.2 171 2.9 HDGF SMAD1 RB1 ZBTB40 ZNF335 EGR1 ZNF207 ZNF143 ATF7 BCLAF1 SLFN13 LIG3 GC17P035445
GH17I035486 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11.6 -38.7 -38706 2.2 CTCF SUZ12 ETV1 MAX RAD21 HIC1 ZNF335 POLR2A EGR1 ATF7 SLFN12L SLFN13 SLFN5 NLE1 CCL23 E2F3P1 ENSG00000267349
GH17I035312 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.8 +135.1 135148 3.1 CTCF USF1 ZNF449 KLF17 SIN3A EBF1 ZNF2 RAD21 ZFHX2 GATA3 ENSG00000267364 SLFN12L SLFN13 ZNF830 SLFN5 CCT6B LOC101060119
GH17I035431 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 6.4 +15.9 15943 3.6 ATF1 ZNF213 ATF7 FOS RUNX3 KLF13 JUNB ZNF518A MAFF SMARCA4 SLFN12 ENSG00000267648 ZNF830 LIG3 ENSG00000267547 SLFN13 GC17M035431 ENSG00000267102
GH17I035529 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 10.9 -82.1 -82145 3.6 CTCF ZNF146 ZNF366 PRDM1 SLFN5 AP2B1 SLFN13 NLE1 SLFN12L RASL10B SLFN12 CCL5 SLFN11 RFFL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLFN13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLFN13 gene promoter:

Genomic Locations for SLFN13 Gene

Genomic Locations for SLFN13 Gene
chr17:35,435,096-35,449,008
(GRCh38/hg38)
Size:
13,913 bases
Orientation:
Minus strand
chr17:33,762,115-33,775,856
(GRCh37/hg19)

Genomic View for SLFN13 Gene

Genes around SLFN13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN13 Gene

Proteins for SLFN13 Gene

  • Protein details for SLFN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68D06-SLN13_HUMAN
    Recommended name:
    Schlafen family member 13
    Protein Accession:
    Q68D06
    Secondary Accessions:
    • E1P645
    • Q658M1
    • Q6ZS51
    • Q96A81

    Protein attributes for SLFN13 Gene

    Size:
    897 amino acids
    Molecular mass:
    102045 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK127728; Type=Frameshift; Positions=261; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLFN13 Gene

Post-translational modifications for SLFN13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFN13 Gene

Domains & Families for SLFN13 Gene

Gene Families for SLFN13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLFN13 Gene

Suggested Antigen Peptide Sequences for SLFN13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68D06

UniProtKB/Swiss-Prot:

SLN13_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN13: view

Function for SLFN13 Gene

Phenotypes From GWAS Catalog for SLFN13 Gene

Gene Ontology (GO) - Molecular Function for SLFN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN13: view

Phenotypes for SLFN13 Gene

GenomeRNAi human phenotypes for SLFN13:
genes like me logo Genes that share phenotypes with SLFN13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN13 Gene

Localization for SLFN13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN13 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLFN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with SLFN13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SLFN13 Gene

Pathways & Interactions for SLFN13 Gene

SuperPathways for SLFN13 Gene

No Data Available

Interacting Proteins for SLFN13 Gene

Gene Ontology (GO) - Biological Process for SLFN13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFN13 Gene

Drugs & Compounds for SLFN13 Gene

No Compound Related Data Available

Transcripts for SLFN13 Gene

Unigene Clusters for SLFN13 Gene

Schlafen family member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6: - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for SLFN13 Gene

GeneLoc Exon Structure for
SLFN13
ECgene alternative splicing isoforms for
SLFN13

Expression for SLFN13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLFN13 Gene

mRNA differential expression in normal tissues according to GTEx for SLFN13 Gene

This gene is overexpressed in Whole Blood (x4.2) and Minor Salivary Gland (x4.0).

Protein differential expression in normal tissues from HIPED for SLFN13 Gene

This gene is overexpressed in Adipocyte (51.6), Platelet (8.7), and Heart (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLFN13 Gene



Protein tissue co-expression partners for SLFN13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFN13 Gene:

SLFN13

SOURCE GeneReport for Unigene cluster for SLFN13 Gene:

Hs.462833

Evidence on tissue expression from TISSUES for SLFN13 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with SLFN13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN13 Gene

Orthologs for SLFN13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN13 33 34
  • 99.22 (n)
mouse
(Mus musculus)
Mammalia Slfn9 33 16 34
  • 72.65 (n)
Slfn8 34
  • 61 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slfn13 33
  • 71.26 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
OneToMany
Species where no ortholog for SLFN13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN13 Gene

ENSEMBL:
Gene Tree for SLFN13 (if available)
TreeFam:
Gene Tree for SLFN13 (if available)

Paralogs for SLFN13 Gene

Paralogs for SLFN13 Gene

(6) SIMAP similar genes for SLFN13 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLFN13: view

Variants for SLFN13 Gene

Sequence variations from dbSNP and Humsavar for SLFN13 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000028843 -- 35,434,724(-) G/A downstream_transcript_variant
rs1000064066 -- 35,446,935(-) G/A 5_prime_UTR_variant, intron_variant
rs1000368026 -- 35,446,582(-) T/C 5_prime_UTR_variant, intron_variant
rs1000517387 -- 35,450,591(-) G/T upstream_transcript_variant
rs1000761277 -- 35,446,772(-) T/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN13 Gene

Variant ID Type Subtype PubMed ID
dgv3142n100 CNV loss 25217958
dgv365n27 CNV loss 19166990
dgv5532n54 CNV loss 21841781
dgv570e214 CNV loss 21293372
dgv571e214 CNV gain 21293372
dgv907e212 CNV loss 25503493
esv2715869 CNV deletion 23290073
esv2762399 CNV loss 21179565
esv3892997 CNV gain+loss 25118596
esv3892999 CNV loss 25118596
nsv457728 CNV gain 19166990
nsv515566 CNV gain+loss 19592680
nsv574741 CNV loss 21841781
nsv574743 CNV loss 21841781
nsv574749 CNV gain+loss 21841781
nsv962312 CNV duplication 23825009

Variation tolerance for SLFN13 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLFN13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFN13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN13 Gene

Disorders for SLFN13 Gene

Additional Disease Information for SLFN13

No disorders were found for SLFN13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN13 Gene

Publications for SLFN13 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz DA … Hedrick SM (Immunity 1998) 2 3 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A … Wiemann S (Nucleic acids research 2006) 3 58

Products for SLFN13 Gene

Sources for SLFN13 Gene

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