Aliases for SLFN12L Gene

Aliases for SLFN12L Gene

  • Schlafen Family Member 12 Like 2 3 5
  • Schlafen Family Member 12-Like 2 3 4
  • SLFN12L 5
  • SLFN5 4

External Ids for SLFN12L Gene

Previous GeneCards Identifiers for SLFN12L Gene

  • GC17M030823
  • GC17M033801
  • GC17M033791

Summaries for SLFN12L Gene

GeneCards Summary for SLFN12L Gene

SLFN12L (Schlafen Family Member 12 Like) is a Protein Coding gene. Diseases associated with SLFN12L include Bleeding Disorder, Platelet-Type, 20. An important paralog of this gene is SLFN12.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLFN12L Gene

Genomics for SLFN12L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLFN12L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLFN12L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLFN12L

Top Transcription factor binding sites by QIAGEN in the SLFN12L gene promoter:
  • AREB6
  • C/EBPalpha
  • FOXI1
  • FOXL1
  • HFH-3
  • HNF-3beta
  • LCR-F1
  • LyF-1
  • Nkx2-2
  • STAT5A

Genomic Locations for SLFN12L Gene

Latest Assembly
73,613 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
62,939 bases
Minus strand

(GRCh37/hg19 by Ensembl)
73,613 bases
Minus strand

Genomic View for SLFN12L Gene

Genes around SLFN12L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN12L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN12L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12L Gene

Proteins for SLFN12L Gene

  • Protein details for SLFN12L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 12-like
    Protein Accession:
    Secondary Accessions:
    • F5H6G3

    Protein attributes for SLFN12L Gene

    588 amino acids
    Molecular mass:
    67096 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD80167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN12L Gene


neXtProt entry for SLFN12L Gene

Post-translational modifications for SLFN12L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFN12L Gene

Domains & Families for SLFN12L Gene

Gene Families for SLFN12L Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLFN12L Gene

  • Ribosomal protein S19/S15

Suggested Antigen Peptide Sequences for SLFN12L Gene

GenScript: Design optimal peptide antigens:
  • Schlafen family member 12-like (SN12L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family.
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12L: view

Function for SLFN12L Gene

Phenotypes From GWAS Catalog for SLFN12L Gene

Phenotypes for SLFN12L Gene

genes like me logo Genes that share phenotypes with SLFN12L: view

Animal Models for SLFN12L Gene

MGI Knock Outs for SLFN12L:
  • Slfn4 Slfn4<tm1b(EUCOMM)Wtsi>

miRNA for SLFN12L Gene

miRTarBase miRNAs that target SLFN12L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLFN12L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLFN12L Gene

Localization for SLFN12L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLFN12L Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN12L gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endosome 1
mitochondrion 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for SLFN12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLFN12L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLFN12L Gene

Pathways & Interactions for SLFN12L Gene

PathCards logo

SuperPathways for SLFN12L Gene

No Data Available

Interacting Proteins for SLFN12L Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000437635 Q6IEE8-SN12L_HUMAN for SLFN12L Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLFN12L Gene


No data available for Pathways by source and SIGNOR curated interactions for SLFN12L Gene

Drugs & Compounds for SLFN12L Gene

No Compound Related Data Available

Transcripts for SLFN12L Gene

mRNA/cDNA for SLFN12L Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLFN12L

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12L Gene

No ASD Table

Relevant External Links for SLFN12L Gene

GeneLoc Exon Structure for

Expression for SLFN12L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLFN12L Gene

mRNA differential expression in normal tissues according to GTEx for SLFN12L Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for SLFN12L Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN12L Gene

Protein tissue co-expression partners for SLFN12L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLFN12L

SOURCE GeneReport for Unigene cluster for SLFN12L Gene:

genes like me logo Genes that share expression patterns with SLFN12L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN12L Gene

Orthologs for SLFN12L Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLFN12L 29 30
  • 98.55 (n)
(Mus musculus)
Mammalia Slfn4 29 16 30
  • 66.87 (n)
Slfn2 30
  • 50 (a)
Slfn1 30
  • 48 (a)
Slfn3 16 30
  • 41 (a)
(Bos Taurus)
Mammalia -- 30
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 15 (a)
Species where no ortholog for SLFN12L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLFN12L Gene

Gene Tree for SLFN12L (if available)
Gene Tree for SLFN12L (if available)
Evolutionary constrained regions (ECRs) for SLFN12L: view image
Alliance of Genome Resources:
Additional Orthologs for SLFN12L

Paralogs for SLFN12L Gene

Paralogs for SLFN12L Gene

(5) SIMAP similar genes for SLFN12L Gene using alignment to 3 proteins:

  • F5H6G3_HUMAN
  • J3KQ81_HUMAN
genes like me logo Genes that share paralogs with SLFN12L: view

Variants for SLFN12L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLFN12L Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs116657840 Benign: not provided 35,479,525(-) T/A
NM_001195790.1(SLFN12L):c.685A>T (p.Thr229Ser)
rs142712023 Benign: not provided 35,480,011(-) A/T
NM_001195790.1(SLFN12L):c.199T>A (p.Cys67Ser)
rs12451679 -- p.Leu275Ser
rs2304967 -- p.Ala373Gly
rs3744372 -- p.Tyr518Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLFN12L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLFN12L Gene

Variant ID Type Subtype PubMed ID
esv3640451 CNV loss 21293372
esv3892999 CNV loss 25118596
nsv472830 CNV novel sequence insertion 20440878
nsv574741 CNV loss 21841781

Variation tolerance for SLFN12L Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLFN12L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN12L Gene

Disorders for SLFN12L Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLFN12L Gene - From: COP

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 20
  • bdplt20
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLFN12L

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLFN12L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLFN12L Gene

Publications for SLFN12L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. (PMID: 20045101) Ferreira MA … Martin NG (American journal of human genetics 2010) 3 40
  3. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A … Costa PT (Biological psychiatry 2010) 3 40
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SLFN12L Gene

Sources for SLFN12L Gene