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Aliases for SLFN12L Gene

Aliases for SLFN12L Gene

  • Schlafen Family Member 12 Like 2 3 5
  • Schlafen Family Member 12-Like 2
  • SLFN5 4

External Ids for SLFN12L Gene

Previous GeneCards Identifiers for SLFN12L Gene

  • GC17M030823
  • GC17M033801
  • GC17M033791

Summaries for SLFN12L Gene

GeneCards Summary for SLFN12L Gene

SLFN12L (Schlafen Family Member 12 Like) is a Protein Coding gene. An important paralog of this gene is SLFN12.

Additional gene information for SLFN12L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN12L Gene

Genomics for SLFN12L Gene

GeneHancer (GH) Regulatory Elements for SLFN12L Gene

Promoters and enhancers for SLFN12L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I035533 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 565.2 +0.2 188 9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZNF2 IRF4 YY1 ARID2 ZNF143 SLFN12L AP2B1 CCL5 ZNF830 PEX12 LIG3 SLFN5 TAF5LP1 GAS2L2 SLFN11
GH17I035486 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 560.9 +50.1 50147 2.2 CTCF SUZ12 ETV1 MAX RAD21 HIC1 ZNF335 POLR2A EGR1 ATF7 SLFN12L SLFN13 SLFN5 NLE1 CCL23 E2F3P1 ENSG00000267349
GH17I035312 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 22.7 +224.0 224001 3.1 CTCF USF1 ZNF449 KLF17 SIN3A EBF1 ZNF2 RAD21 ZFHX2 GATA3 ENSG00000267364 SLFN12L SLFN13 ZNF830 SLFN5 CCT6B LOC101060119
GH17I035586 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -51.4 -51368 5.4 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 AP2B1 PEX12 LIG3 LINC02001 RASL10B C17orf50 SLFN12L LOC100420062 GAS2L2 GC17M035597
GH17I035212 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 18 +322.8 322770 5.4 PKNOX1 ETV1 ZNF133 BATF GABPA NCOA2 OSR2 PRDM6 ZNF157 CUX1 SLFN5 NLE1 SLFN12L AP2B1 LINC02001 UNC45B ZNF830 SLC35G3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLFN12L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLFN12L gene promoter:

Genomic Locations for SLFN12L Gene

Genomic Locations for SLFN12L Gene
chr17:35,464,249-35,537,861
(GRCh38/hg38)
Size:
73,613 bases
Orientation:
Minus strand
chr17:33,791,268-33,864,880
(GRCh37/hg19)

Genomic View for SLFN12L Gene

Genes around SLFN12L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN12L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN12L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12L Gene

Proteins for SLFN12L Gene

  • Protein details for SLFN12L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEE8-SN12L_HUMAN
    Recommended name:
    Schlafen family member 12-like
    Protein Accession:
    Q6IEE8
    Secondary Accessions:
    • F5H6G3

    Protein attributes for SLFN12L Gene

    Size:
    588 amino acids
    Molecular mass:
    67096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD80167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN12L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLFN12L Gene

Post-translational modifications for SLFN12L Gene

No Post-translational modifications

Other Protein References for SLFN12L Gene

No data available for DME Specific Peptides for SLFN12L Gene

Domains & Families for SLFN12L Gene

Gene Families for SLFN12L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLFN12L Gene

Suggested Antigen Peptide Sequences for SLFN12L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IEE8

UniProtKB/Swiss-Prot:

SN12L_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12L: view

Function for SLFN12L Gene

Phenotypes From GWAS Catalog for SLFN12L Gene

Gene Ontology (GO) - Molecular Function for SLFN12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN12L: view

Phenotypes for SLFN12L Gene

MGI mutant phenotypes for SLFN12L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLFN12L: view

Animal Models for SLFN12L Gene

MGI Knock Outs for SLFN12L:

miRNA for SLFN12L Gene

miRTarBase miRNAs that target SLFN12L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLFN12L Gene

Localization for SLFN12L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLFN12L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN12L gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLFN12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLFN12L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLFN12L Gene

Pathways & Interactions for SLFN12L Gene

SuperPathways for SLFN12L Gene

No Data Available

Interacting Proteins for SLFN12L Gene

Selected Interacting proteins: Q6IEE8-SN12L_HUMAN for SLFN12L Gene via IID

Symbol External ID(s) Details
CAND1
COPS5

Gene Ontology (GO) - Biological Process for SLFN12L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFN12L Gene

Drugs & Compounds for SLFN12L Gene

No Compound Related Data Available

Transcripts for SLFN12L Gene

mRNA/cDNA for SLFN12L Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLFN12L Gene

Schlafen family member 12-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12L Gene

No ASD Table

Relevant External Links for SLFN12L Gene

GeneLoc Exon Structure for
SLFN12L
ECgene alternative splicing isoforms for
SLFN12L

Expression for SLFN12L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLFN12L Gene

mRNA differential expression in normal tissues according to GTEx for SLFN12L Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for SLFN12L Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN12L Gene



Protein tissue co-expression partners for SLFN12L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFN12L Gene:

SLFN12L

SOURCE GeneReport for Unigene cluster for SLFN12L Gene:

Hs.447559
genes like me logo Genes that share expression patterns with SLFN12L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN12L Gene

Orthologs for SLFN12L Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN12L 33 34
  • 98.55 (n)
mouse
(Mus musculus)
Mammalia Slfn4 33 16 34
  • 66.87 (n)
Slfn2 34
  • 50 (a)
ManyToMany
Slfn1 34
  • 48 (a)
ManyToMany
Slfn3 34
  • 41 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 15 (a)
OneToMany
Species where no ortholog for SLFN12L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN12L Gene

ENSEMBL:
Gene Tree for SLFN12L (if available)
TreeFam:
Gene Tree for SLFN12L (if available)

Paralogs for SLFN12L Gene

Paralogs for SLFN12L Gene

(5) SIMAP similar genes for SLFN12L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLFN12L: view

Variants for SLFN12L Gene

Sequence variations from dbSNP and Humsavar for SLFN12L Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000033791 -- 35,528,681(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000064225 -- 35,505,840(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000166071 -- 35,491,271(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000255750 -- 35,528,852(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000261669 -- 35,480,418(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN12L Gene

Variant ID Type Subtype PubMed ID
nsv574741 CNV loss 21841781
nsv472830 CNV novel sequence insertion 20440878
esv3892999 CNV loss 25118596
esv3640451 CNV loss 21293372

Variation tolerance for SLFN12L Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLFN12L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFN12L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN12L Gene

Disorders for SLFN12L Gene

Additional Disease Information for SLFN12L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLFN12L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN12L Gene

Publications for SLFN12L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. (PMID: 20045101) Ferreira MA … Martin NG (American journal of human genetics 2010) 3 44 58
  3. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A … Costa PT (Biological psychiatry 2010) 3 44 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SLFN12L Gene

Sources for SLFN12L Gene

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