Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLCO6A1 Gene

Aliases for SLCO6A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 6A1 2 3 3 5
  • Cancer/Testis Antigen 48 2 3 4
  • Organic Anion-Transporting Polypeptide I 3 4
  • Solute Carrier Family 21 Member 19 3 4
  • Gonad-Specific Transporter 3 4
  • OATP6A1 3 4
  • OATP-I 3 4
  • CT48 3 4
  • GST 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 6A1 2
  • Organic Anion-Transporting Polypeptide 6A1 4
  • Testis-Specific Organic Anion Transporter 3
  • Testicular Tissue Protein Li 174 3
  • SLC21A19 4
  • OATPY 3

External Ids for SLCO6A1 Gene

Previous GeneCards Identifiers for SLCO6A1 Gene

  • GC05M101783
  • GC05M101735
  • GC05M096889

Summaries for SLCO6A1 Gene

GeneCards Summary for SLCO6A1 Gene

SLCO6A1 (Solute Carrier Organic Anion Transporter Family Member 6A1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4C1.

Additional gene information for SLCO6A1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO6A1 Gene

Genomics for SLCO6A1 Gene

GeneHancer (GH) Regulatory Elements for SLCO6A1 Gene

Promoters and enhancers for SLCO6A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J102498 Promoter 0.6 EPDnew 656.1 +0.8 756 0.1 L3MBTL2 SLCO6A1 ENSG00000249017 RN7SKP68
GH05J102295 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.9 +203.4 203433 2.5 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 NFYC MXD4 KAT8 SREBF1 SLCO4C1 PAM SLCO6A1 GC05P102158
GH05J102523 Enhancer 0.5 Ensembl 16.9 -23.9 -23945 0.4 MAFG DPF2 ZNF24 RUNX3 MAFK SPI1 SLCO6A1 ENSG00000249017 SLCO4C1 LINC00492
GH05J102528 Enhancer 0.2 ENCODE 17.1 -29.7 -29745 1.8 SLCO6A1 ENSG00000249017 PAM LINC00492
GH05J102242 Enhancer 0.5 FANTOM5 5.5 +257.6 257594 0.1 SP1 HNF1A RXRA REST RAD21 SLCO6A1 SLCO4C1 GC05P102158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO6A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO6A1 gene promoter:
  • GR-alpha
  • GR
  • AREB6
  • STAT5A
  • c-Myc
  • Max
  • C/EBPbeta
  • Max1
  • POU6F1 (c2)

Genomic Locations for SLCO6A1 Gene

Genomic Locations for SLCO6A1 Gene
127,875 bases
Minus strand
127,235 bases
Minus strand

Genomic View for SLCO6A1 Gene

Genes around SLCO6A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO6A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO6A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO6A1 Gene

Proteins for SLCO6A1 Gene

  • Protein details for SLCO6A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 6A1
    Protein Accession:
    Secondary Accessions:
    • A6NHC1
    • Q6ZMY5
    • Q86UV2
    • Q8IYU5

    Protein attributes for SLCO6A1 Gene

    719 amino acids
    Molecular mass:
    79232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO6A1 Gene


neXtProt entry for SLCO6A1 Gene

Post-translational modifications for SLCO6A1 Gene

  • Glycosylation at isoforms=2, 3661, isoforms=2, 3546, posLast=497497, and posLast=300300
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO6A1 Gene

Domains & Families for SLCO6A1 Gene

Gene Families for SLCO6A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLCO6A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO6A1: view

Function for SLCO6A1 Gene

Phenotypes From GWAS Catalog for SLCO6A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO6A1: view
genes like me logo Genes that share phenotypes with SLCO6A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO6A1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO6A1 Gene

Localization for SLCO6A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO6A1 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO6A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO6A1 Gene

Pathways & Interactions for SLCO6A1 Gene

SuperPathways for SLCO6A1 Gene

No Data Available

Interacting Proteins for SLCO6A1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
Selected Interacting proteins: ENSP00000369135 Q86UG4-SO6A1_HUMAN for SLCO6A1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO6A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO6A1 Gene

Drugs & Compounds for SLCO6A1 Gene

(2) Drugs for SLCO6A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLCO6A1: view

Transcripts for SLCO6A1 Gene

mRNA/cDNA for SLCO6A1 Gene

(10) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLCO6A1 Gene

Solute carrier organic anion transporter family, member 6A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO6A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO6A1 Gene

No ASD Table

Relevant External Links for SLCO6A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO6A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO6A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLCO6A1 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for SLCO6A1 Gene

This gene is overexpressed in Plasma (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO6A1 Gene

Protein tissue co-expression partners for SLCO6A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLCO6A1 Gene:


SOURCE GeneReport for Unigene cluster for SLCO6A1 Gene:


mRNA Expression by UniProt/SwissProt for SLCO6A1 Gene:

Tissue specificity: Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors.

Evidence on tissue expression from TISSUES for SLCO6A1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLCO6A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO6A1 Gene

Orthologs for SLCO6A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO6A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO6A1 34 33
  • 99.17 (n)
(Canis familiaris)
Mammalia SLCO6A1 34 33
  • 75.47 (n)
(Mus musculus)
Mammalia Slco6b1 16 34 33
  • 66.24 (n)
Slco6c1 34
  • 38 (a)
Slco6d1 34
  • 34 (a)
(Rattus norvegicus)
Mammalia Slco6b1 33
  • 63.56 (n)
(Bos Taurus)
Mammalia SLCO6A1 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
(Monodelphis domestica)
Mammalia SLCO6A1 34
  • 35 (a)
(Gallus gallus)
Aves -- 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp58Db 34
  • 16 (a)
(Caenorhabditis elegans)
Secernentea Y70G10A.3 34
  • 23 (a)
K02G10.5 34
  • 22 (a)
F53B1.8 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 27 (a)
Species where no ortholog for SLCO6A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLCO6A1 Gene

Gene Tree for SLCO6A1 (if available)
Gene Tree for SLCO6A1 (if available)
Evolutionary constrained regions (ECRs) for SLCO6A1: view image

Paralogs for SLCO6A1 Gene

(6) SIMAP similar genes for SLCO6A1 Gene using alignment to 4 proteins:

  • C9J020_HUMAN
  • H0Y8R6_HUMAN
genes like me logo Genes that share paralogs with SLCO6A1: view

Variants for SLCO6A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO6A1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000001316 -- 102,453,221(-) T/G intron_variant
rs1000007143 -- 102,503,205(-) A/G upstream_transcript_variant
rs1000011545 -- 102,463,220(-) A/G intron_variant
rs1000038206 -- 102,503,559(-) A/T upstream_transcript_variant
rs1000056480 -- 102,464,049(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO6A1 Gene

Variant ID Type Subtype PubMed ID
dgv1630e212 CNV gain 25503493
dgv350n21 CNV gain 19592680
nsv830428 CNV gain+loss 17160897
nsv830427 CNV gain 17160897
nsv599189 CNV gain 21841781
nsv522882 CNV loss 19592680
nsv462325 CNV loss 19166990
nsv462324 CNV gain 19166990
nsv1030022 CNV loss 25217958
nsv1029894 CNV gain 25217958
nsv1028787 CNV gain 25217958
nsv1022583 CNV gain 25217958
nsv1020531 CNV loss 25217958
nsv1015892 CNV gain 25217958
esv3606051 CNV gain 21293372
esv3606050 CNV gain 21293372
esv3606048 CNV gain 21293372
esv3606047 CNV gain 21293372
esv3575866 CNV gain 25503493
esv2730532 CNV deletion 23290073
esv2730531 CNV deletion 23290073
esv2730530 CNV deletion 23290073
esv2730529 CNV deletion 23290073
esv2730527 CNV deletion 23290073
esv1929846 CNV deletion 18987734
dgv9977n54 CNV loss 21841781

Variation tolerance for SLCO6A1 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO6A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Disorders for SLCO6A1 Gene

Additional Disease Information for SLCO6A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLCO6A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLCO6A1 Gene

Publications for SLCO6A1 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic polymorphisms in Thai neonates with hyperbilirubinemia. (PMID: 19397531) Prachukthum S … Hongeng S (Acta paediatrica (Oslo, Norway : 1992) 2009) 3 44 58
  4. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H … Collier DA (Nature 2009) 3 44 58
  5. Identification and characterization of novel rat and human gonad-specific organic anion transporters. (PMID: 12677006) Suzuki T … Abe T (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 58

Products for SLCO6A1 Gene

Sources for SLCO6A1 Gene

Loading form....