Aliases for SLCO6A1 Gene

Aliases for SLCO6A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 6A1 2 3 4 5
  • Cancer/Testis Antigen 48 2 3 4
  • OATP6A1 2 3 4
  • CT48 2 3 4
  • Organic Anion-Transporting Polypeptide I 3 4
  • Solute Carrier Family 21 Member 19 3 4
  • Gonad-Specific Transporter 3 4
  • OATP-I 3 4
  • OATPY 2 3
  • GST 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 6A1 2
  • Organic Anion-Transporting Polypeptide 6A1 4
  • Testis-Specific Organic Anion Transporter 3
  • Testicular Tissue Protein Li 174 3
  • MGC26949 2
  • SLC21A19 4
  • SLCO6A1 5

External Ids for SLCO6A1 Gene

Previous GeneCards Identifiers for SLCO6A1 Gene

  • GC05M101783
  • GC05M101735
  • GC05M096889

Summaries for SLCO6A1 Gene

GeneCards Summary for SLCO6A1 Gene

SLCO6A1 (Solute Carrier Organic Anion Transporter Family Member 6A1) is a Protein Coding gene. Diseases associated with SLCO6A1 include Lateral Medullary Syndrome and Inflammatory Bowel Disease 7. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4C1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLCO6A1 Gene

Genomics for SLCO6A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLCO6A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J102498 Promoter 0.4 EPDnew 606 +3.3 3313 0.1 L3MBTL2 SLCO6A1 ENSG00000249017 piR-39098-208 SLCO4C1
GH05J102294 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.9 +206.3 206283 3.1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 ZNF692 ZNF143 ZIC2 RBFOX2 PATZ1 SLCO4C1 PAM SLCO6A1 piR-38351-382
GH05J102523 Enhancer 0.5 Ensembl 16.9 -21.4 -21387 1.6 DPF2 RUNX3 ZNF316 MAFF MAFK MAFG TBX21 ZNF24 SPI1 SLCO6A1 ENSG00000249017 SLCO4C1 LINC00491 PPIP5K2 HSALNG0043859 RF00017-4805 PAM
GH05J102596 Enhancer 0.6 Ensembl 10.4 -94.1 -94088 0.6 RELA IKZF2 DPF2 RELB RUNX3 BCL11A ARNT ELF1 IKZF1 NR2F1 SLCO6A1 ENSG00000249017 ENSG00000247402 LINC00492 PAM
GH05J102271 Enhancer 0.5 Ensembl 10.2 +230.2 230213 0.4 CEBPA EZH2 USF1 RCOR1 HOMEZ NR2F6 CEBPB PPARG ENSG00000249017 SLCO6A1 PAM SLCO4C1 piR-38351-382
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLCO6A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLCO6A1

Top Transcription factor binding sites by QIAGEN in the SLCO6A1 gene promoter:
  • AREB6
  • c-Myc
  • C/EBPbeta
  • GR
  • GR-alpha
  • Max
  • Max1
  • POU6F1 (c2)
  • STAT5A

Genomic Locations for SLCO6A1 Gene

Genomic Locations for SLCO6A1 Gene
130,440 bases
Minus strand
127,235 bases
Minus strand

Genomic View for SLCO6A1 Gene

Genes around SLCO6A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO6A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO6A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO6A1 Gene

Proteins for SLCO6A1 Gene

  • Protein details for SLCO6A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 6A1
    Protein Accession:
    Secondary Accessions:
    • A6NHC1
    • Q6ZMY5
    • Q86UV2
    • Q8IYU5

    Protein attributes for SLCO6A1 Gene

    719 amino acids
    Molecular mass:
    79232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO6A1 Gene


neXtProt entry for SLCO6A1 Gene

Post-translational modifications for SLCO6A1 Gene

  • Glycosylation at Asn300, Asn497, Asn546, and Asn661
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO6A1 Gene

Domains & Families for SLCO6A1 Gene

Gene Families for SLCO6A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLCO6A1 Gene

  • Protease inhibitor, Kazal-type
  • Organic anion transporter polypeptide (OATP), N-terminal

Suggested Antigen Peptide Sequences for SLCO6A1 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier organic anion transporter family, member 6A1, isoform CRA_b (D3DSZ4_HUMAN)
  • Solute carrier family 21 member 19 (SO6A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO6A1: view

Function for SLCO6A1 Gene

Phenotypes From GWAS Catalog for SLCO6A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLCO6A1: view
genes like me logo Genes that share phenotypes with SLCO6A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO6A1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO6A1 Gene

Localization for SLCO6A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO6A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO6A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO6A1 Gene

Pathways & Interactions for SLCO6A1 Gene

PathCards logo

SuperPathways for SLCO6A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0043252 sodium-independent organic anion transport IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO6A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO6A1 Gene

Drugs & Compounds for SLCO6A1 Gene

(2) Drugs for SLCO6A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLCO6A1: view

Transcripts for SLCO6A1 Gene

mRNA/cDNA for SLCO6A1 Gene

10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO6A1

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO6A1 Gene

No ASD Table

Relevant External Links for SLCO6A1 Gene

GeneLoc Exon Structure for

Expression for SLCO6A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO6A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SLCO6A1 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for SLCO6A1 Gene

This gene is overexpressed in Plasma (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO6A1 Gene

Protein tissue co-expression partners for SLCO6A1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLCO6A1

SOURCE GeneReport for Unigene cluster for SLCO6A1 Gene:


mRNA Expression by UniProt/SwissProt for SLCO6A1 Gene:

Tissue specificity: Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors.

Evidence on tissue expression from TISSUES for SLCO6A1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLCO6A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO6A1 Gene

Orthologs for SLCO6A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO6A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO6A1 30 31
  • 99.17 (n)
(Canis familiaris)
Mammalia SLCO6A1 30 31
  • 75.47 (n)
(Mus musculus)
Mammalia Slco6b1 30 17 31
  • 66.24 (n)
Slco6c1 31
  • 38 (a)
Slco6d1 31
  • 34 (a)
(Rattus norvegicus)
Mammalia Slco6b1 30
  • 63.56 (n)
(Bos Taurus)
Mammalia SLCO6A1 31
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
(Monodelphis domestica)
Mammalia SLCO6A1 31
  • 35 (a)
(Gallus gallus)
Aves -- 31
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 29 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Oatp58Db 31
  • 16 (a)
(Caenorhabditis elegans)
Secernentea Y70G10A.3 31
  • 23 (a)
K02G10.5 31
  • 22 (a)
F53B1.8 31
  • 19 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
-- 31
  • 27 (a)
-- 31
  • 27 (a)
Species where no ortholog for SLCO6A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for SLCO6A1 Gene

Gene Tree for SLCO6A1 (if available)
Gene Tree for SLCO6A1 (if available)
Evolutionary constrained regions (ECRs) for SLCO6A1: view image

Paralogs for SLCO6A1 Gene

(6) SIMAP similar genes for SLCO6A1 Gene using alignment to 4 proteins:

  • C9J020_HUMAN
  • H0Y8R6_HUMAN
genes like me logo Genes that share paralogs with SLCO6A1: view

Variants for SLCO6A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLCO6A1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
713079 Likely Benign: not provided 102,373,384(-) T/C MISSENSE_VARIANT
715454 Benign: not provided 102,399,669(-) C/G MISSENSE_VARIANT
721376 Benign: not provided 102,373,370(-) T/C SYNONYMOUS_VARIANT
769301 Benign: not provided 102,480,184(-) T/C SYNONYMOUS_VARIANT
777976 Benign: not provided 102,458,463(-) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SLCO6A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLCO6A1 Gene

Variant ID Type Subtype PubMed ID
dgv1630e212 CNV gain 25503493
dgv350n21 CNV gain 19592680
dgv9977n54 CNV loss 21841781
esv1929846 CNV deletion 18987734
esv2730527 CNV deletion 23290073
esv2730529 CNV deletion 23290073
esv2730530 CNV deletion 23290073
esv2730531 CNV deletion 23290073
esv2730532 CNV deletion 23290073
esv3575866 CNV gain 25503493
esv3606047 CNV gain 21293372
esv3606048 CNV gain 21293372
esv3606050 CNV gain 21293372
esv3606051 CNV gain 21293372
nsv1015892 CNV gain 25217958
nsv1020531 CNV loss 25217958
nsv1022583 CNV gain 25217958
nsv1028787 CNV gain 25217958
nsv1029894 CNV gain 25217958
nsv1030022 CNV loss 25217958
nsv462324 CNV gain 19166990
nsv462325 CNV loss 19166990
nsv522882 CNV loss 19592680
nsv599189 CNV gain 21841781
nsv830427 CNV gain 17160897
nsv830428 CNV gain+loss 17160897

Variation tolerance for SLCO6A1 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO6A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Disorders for SLCO6A1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLCO6A1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lateral medullary syndrome
  • vertebral artery syndrome
inflammatory bowel disease 7
  • ibd7
pulmonary valve insufficiency
  • pulmonary incompetence
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO6A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLCO6A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO6A1 Gene

Publications for SLCO6A1 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H … Collier DA (Nature 2009) 3 41
  4. Genetic polymorphisms in Thai neonates with hyperbilirubinemia. (PMID: 19397531) Prachukthum S … Hongeng S (Acta paediatrica (Oslo, Norway : 1992) 2009) 3 41
  5. Identification and characterization of novel rat and human gonad-specific organic anion transporters. (PMID: 12677006) Suzuki T … Abe T (Molecular endocrinology (Baltimore, Md.) 2003) 3 4

Products for SLCO6A1 Gene

Sources for SLCO6A1 Gene