This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] See more...

Aliases for SLCO5A1 Gene

Aliases for SLCO5A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 5A1 2 3 4 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 15 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 4 3 4
  • Solute Carrier Family 21 Member 15 3 4
  • SLC21A15 3 4
  • OATP-RP4 3 4
  • OATP5A1 3 4
  • OATPRP4 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 5A1 2
  • OATP-J 3
  • OATPJ 3

External Ids for SLCO5A1 Gene

Previous HGNC Symbols for SLCO5A1 Gene

  • SLC21A15

Previous GeneCards Identifiers for SLCO5A1 Gene

  • GC08M070634
  • GC08M070748
  • GC08M070584
  • GC08M066078

Summaries for SLCO5A1 Gene

Entrez Gene Summary for SLCO5A1 Gene

  • This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO5A1 Gene

SLCO5A1 (Solute Carrier Organic Anion Transporter Family Member 5A1) is a Protein Coding gene. Diseases associated with SLCO5A1 include Mesomelia-Synostoses Syndrome and Mesomelia. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4A1.

Additional gene information for SLCO5A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLCO5A1 Gene

Genomics for SLCO5A1 Gene

GeneHancer (GH) Regulatory Elements for SLCO5A1 Gene

Promoters and enhancers for SLCO5A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J069830 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +2.4 2363 6.2 ZBTB40 EP300 CTCF SIN3A NRF1 ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 LOC101929759 SLCO5A1 lnc-PRDM14-5 RF00017-7113
GH08J070073 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 10.3 -236.0 -236037 4.2 SAP30 EZH2 HDAC2 POLR2A YY1 NANOG PHF8 ETS1 BMI1 EGR1 PRDM14 LOC101929759 SLCO5A1 RF00017-7119
GH08J069763 Enhancer 0.9 Ensembl ENCODE 11.4 +70.6 70602 1.1 ZBTB40 EP300 TRIM22 OSR2 BCL11A FOXA2 FOS ARNT MEF2B NBN LOC101929759 SLCO5A1 RN7SKP29 ENSG00000254557 RF00017-7112 piR-38051-279
GH08J069737 Enhancer 0.9 Ensembl ENCODE 10.8 +96.7 96663 2 ZBTB40 EP300 MEF2C RCOR1 POLR2A NFYB RELA TCF12 ZNF384 SRF ENSG00000254557 RN7SKP29 LOC101929759 SLCO5A1 LACTB2 piR-38051-279 RF00017-7112
GH08J069979 Enhancer 1 Ensembl ENCODE dbSUPER 10.1 -144.0 -144009 3.9 TEAD4 HDAC2 ZNF274 TCF12 NANOG POU2F2 JUN SMARCA4 JUND JUNB RNU1-101P LOC101929759 SLCO5A1 RF00876-026 SDCBPP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLCO5A1

Top Transcription factor binding sites by QIAGEN in the SLCO5A1 gene promoter:
  • c-Myb
  • Meis-1
  • N-Myc
  • NF-kappaB
  • NF-kappaB1
  • p53
  • POU2F1
  • POU2F1a
  • RelA
  • Sox5

Genomic Locations for SLCO5A1 Gene

Genomic Locations for SLCO5A1 Gene
chr8:69,667,046-69,835,064
(GRCh38/hg38)
Size:
168,019 bases
Orientation:
Minus strand
chr8:70,579,282-70,747,299
(GRCh37/hg19)
Size:
168,018 bases
Orientation:
Minus strand

Genomic View for SLCO5A1 Gene

Genes around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO5A1 Gene

Proteins for SLCO5A1 Gene

  • Protein details for SLCO5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2Y9-SO5A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 5A1
    Protein Accession:
    Q9H2Y9
    Secondary Accessions:
    • A4QPC2
    • B2RPF7
    • B3KMU7
    • E9PKK5
    • G3V1C0

    Protein attributes for SLCO5A1 Gene

    Size:
    848 amino acids
    Molecular mass:
    91864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO5A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO5A1 Gene

Post-translational modifications for SLCO5A1 Gene

  • Glycosylation at Asn228, Asn241, Asn469, Asn550, Asn590, Asn597, and Asn730
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO5A1 Gene

Domains & Families for SLCO5A1 Gene

Gene Families for SLCO5A1 Gene

Protein Domains for SLCO5A1 Gene

Blocks:
  • Protease inhibitor, Kazal-type
  • Organic anion transporter polypeptide (OATP), N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLCO5A1 Gene

GenScript: Design optimal peptide antigens:
  • SLCO5A1 protein (A4QPC2_HUMAN)
  • Solute carrier family 21 member 15 (SO5A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2Y9

UniProtKB/Swiss-Prot:

SO5A1_HUMAN :
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO5A1: view

Function for SLCO5A1 Gene

Phenotypes From GWAS Catalog for SLCO5A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLCO5A1: view
genes like me logo Genes that share phenotypes with SLCO5A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO5A1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO5A1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO5A1 Gene

Localization for SLCO5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO5A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLCO5A1: view

Pathways & Interactions for SLCO5A1 Gene

PathCards logo

SuperPathways for SLCO5A1 Gene

No Data Available

Interacting Proteins for SLCO5A1 Gene

;

Gene Ontology (GO) - Biological Process for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043252 sodium-independent organic anion transport IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO5A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO5A1 Gene

Drugs & Compounds for SLCO5A1 Gene

No Compound Related Data Available

Transcripts for SLCO5A1 Gene

mRNA/cDNA for SLCO5A1 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO5A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO5A1 Gene

No ASD Table

Relevant External Links for SLCO5A1 Gene

GeneLoc Exon Structure for
SLCO5A1

Expression for SLCO5A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO5A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO5A1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Heart - Left Ventricle (x8.4), and Heart - Atrial Appendage (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLCO5A1

SOURCE GeneReport for Unigene cluster for SLCO5A1 Gene:

Hs.443609
genes like me logo Genes that share expression patterns with SLCO5A1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO5A1 Gene

Orthologs for SLCO5A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO5A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO5A1 31 30
  • 99.53 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO5A1 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO5A1 31 30
  • 91.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLCO5A1 31 30
  • 88.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slco5a1 17 31 30
  • 86.23 (n)
oppossum
(Monodelphis domestica)
Mammalia SLCO5A1 31
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco5a1 30
  • 84.24 (n)
chicken
(Gallus gallus)
Aves SLCO5A1 31 30
  • 80.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO5A1 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco5a1 30
  • 74.21 (n)
Str.19838 30
zebrafish
(Danio rerio)
Actinopterygii SLCO5A1 (2 of 2) 31
  • 72 (a)
OneToMany
slco5a1 31
  • 69 (a)
OneToMany
LOC556735 30
  • 67.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oatp30B 31 30
  • 50.5 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008711 30
  • 48.88 (n)
worm
(Caenorhabditis elegans)
Secernentea F21G4.1 31
  • 24 (a)
OneToMany
F47E1.4 31
  • 24 (a)
OneToMany
F47E1.2 31
  • 23 (a)
OneToMany
Y32F6B.1 31
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Cin.9649 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9649 30
Species where no ortholog for SLCO5A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO5A1 Gene

ENSEMBL:
Gene Tree for SLCO5A1 (if available)
TreeFam:
Gene Tree for SLCO5A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLCO5A1: view image

Paralogs for SLCO5A1 Gene

(13) SIMAP similar genes for SLCO5A1 Gene using alignment to 2 proteins:

  • SO5A1_HUMAN
  • E9PPI0_HUMAN
genes like me logo Genes that share paralogs with SLCO5A1: view

Variants for SLCO5A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLCO5A1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
708804 Benign: not provided 69,761,829(-) T/C SYNONYMOUS_VARIANT
733417 Likely Benign: not provided 69,755,469(-) C/T MISSENSE_VARIANT
735964 Likely Benign: not provided 69,832,441(-) G/C MISSENSE_VARIANT
774244 Benign: not provided 69,832,363(-) G/C MISSENSE_VARIANT
776355 Benign: not provided 69,673,088(-) G/C SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for SLCO5A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLCO5A1 Gene

Variant ID Type Subtype PubMed ID
dgv92n68 CNV loss 17160897
esv22621 CNV gain 19812545
esv33249 CNV loss 17666407
esv3617554 CNV loss 21293372
esv5772 CNV gain 19470904
nsv1068714 OTHER inversion 25765185
nsv6244 CNV deletion 18451855

Variation tolerance for SLCO5A1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO5A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO5A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Disorders for SLCO5A1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLCO5A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mesomelia-synostoses syndrome
  • chromosome 8q13 deletion syndrome
mesomelia
branchiootorenal syndrome
  • branchiootorenal dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO5A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO5A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO5A1 Gene

Publications for SLCO5A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J … NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (PLoS genetics 2009) 3 41 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The superfamily of organic anion transporting polypeptides. (PMID: 12507753) Hagenbuch B … Meier PJ (Biochimica et biophysica acta 2003) 2 3 54
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54

Products for SLCO5A1 Gene

Sources for SLCO5A1 Gene