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Aliases for SLCO5A1 Gene

Aliases for SLCO5A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 5A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 15 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 4 3 4
  • Solute Carrier Family 21 Member 15 3 4
  • SLC21A15 3 4
  • OATP-RP4 3 4
  • OATP5A1 3 4
  • OATPRP4 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 5A1 2
  • OATP-J 3
  • OATPJ 3

External Ids for SLCO5A1 Gene

Previous HGNC Symbols for SLCO5A1 Gene

  • SLC21A15

Previous GeneCards Identifiers for SLCO5A1 Gene

  • GC08M070634
  • GC08M070748
  • GC08M070584
  • GC08M066078

Summaries for SLCO5A1 Gene

Entrez Gene Summary for SLCO5A1 Gene

  • This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO5A1 Gene

SLCO5A1 (Solute Carrier Organic Anion Transporter Family Member 5A1) is a Protein Coding gene. Diseases associated with SLCO5A1 include Mesomelia-Synostoses Syndrome and Mesomelia. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4A1.

Additional gene information for SLCO5A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO5A1 Gene

Genomics for SLCO5A1 Gene

GeneHancer (GH) Regulatory Elements for SLCO5A1 Gene

Promoters and enhancers for SLCO5A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I069832 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.1 1122 3.4 HDGF PKNOX1 FEZF1 GLI4 ZNF2 YY1 ZNF121 GLIS2 ZNF213 ZNF207 LOC101929759 SLCO5A1 LOC100129096 NCOA2 LOC100101127 GC08P069795
GH08I069675 Enhancer 0.8 Ensembl ENCODE 15.3 +158.6 158647 1.6 PKNOX1 BACH1 JUNB ELF1 DPF2 BATF ATF2 POLR2A NFATC1 IKZF1 SLCO5A1 LOC105375889 LOC101929759 GC08M069668 RN7SKP29
GH08I069763 Enhancer 1 Ensembl ENCODE 11.4 +70.7 70655 1 HDGF PKNOX1 KLF1 FOXA2 BACH1 BMI1 KLF5 ZFHX2 GATA3 ZNF366 LOC101929759 SLCO5A1 RN7SKP29 LOC105375889 GC08P069795 LOC100101127
GH08I070070 Promoter/Enhancer 1 EPDnew ENCODE 10.3 -236.8 -236765 2.2 CTCF POLR2A BACH1 SIN3A CTBP2 ETS1 EZH2 PRDM14 SLCO5A1 LOC101929759 RNU1-101P
GH08I069978 Enhancer 0.7 ENCODE dbSUPER 10 -144.5 -144520 1.4 IKZF1 POU5F1 JUNB RUNX3 LOC101929759 SLCO5A1 GC08M069988 SDCBPP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO5A1 gene promoter:

Genomic Locations for SLCO5A1 Gene

Genomic Locations for SLCO5A1 Gene
168,019 bases
Minus strand

Genomic View for SLCO5A1 Gene

Genes around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO5A1 Gene

Proteins for SLCO5A1 Gene

  • Protein details for SLCO5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 5A1
    Protein Accession:
    Secondary Accessions:
    • A4QPC2
    • B2RPF7
    • B3KMU7
    • E9PKK5
    • G3V1C0

    Protein attributes for SLCO5A1 Gene

    848 amino acids
    Molecular mass:
    91864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO5A1 Gene


neXtProt entry for SLCO5A1 Gene

Post-translational modifications for SLCO5A1 Gene

  • Glycosylation at isoforms=2, 3228, isoforms=2, 3241, isoforms=3469, isoforms=2, 3550, posLast=590590, isoforms=2, 3597, and posLast=730730
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO5A1 Gene

Domains & Families for SLCO5A1 Gene

Gene Families for SLCO5A1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLCO5A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO5A1: view

Function for SLCO5A1 Gene

Phenotypes From GWAS Catalog for SLCO5A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO5A1: view
genes like me logo Genes that share phenotypes with SLCO5A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO5A1

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO5A1 Gene

Localization for SLCO5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO5A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO5A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO5A1 Gene

Pathways & Interactions for SLCO5A1 Gene

SuperPathways for SLCO5A1 Gene

No Data Available

Interacting Proteins for SLCO5A1 Gene

Gene Ontology (GO) - Biological Process for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO5A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO5A1 Gene

Drugs & Compounds for SLCO5A1 Gene

No Compound Related Data Available

Transcripts for SLCO5A1 Gene

Unigene Clusters for SLCO5A1 Gene

Solute carrier organic anion transporter family, member 5A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO5A1 Gene

No ASD Table

Relevant External Links for SLCO5A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO5A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO5A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO5A1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Heart - Left Ventricle (x8.4), and Heart - Atrial Appendage (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of SLCO5A1 Gene:


SOURCE GeneReport for Unigene cluster for SLCO5A1 Gene:

genes like me logo Genes that share expression patterns with SLCO5A1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO5A1 Gene

Orthologs for SLCO5A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO5A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO5A1 33 34
  • 99.53 (n)
(Ornithorhynchus anatinus)
Mammalia SLCO5A1 34
  • 94 (a)
(Canis familiaris)
Mammalia SLCO5A1 33 34
  • 91.23 (n)
(Bos Taurus)
Mammalia SLCO5A1 33 34
  • 88.89 (n)
(Mus musculus)
Mammalia Slco5a1 33 16 34
  • 86.23 (n)
(Monodelphis domestica)
Mammalia SLCO5A1 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Slco5a1 33
  • 84.24 (n)
(Gallus gallus)
Aves SLCO5A1 33 34
  • 80.71 (n)
(Anolis carolinensis)
Reptilia SLCO5A1 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco5a1 33
  • 74.21 (n)
Str.19838 33
(Danio rerio)
Actinopterygii SLCO5A1 (2 of 2) 34
  • 72 (a)
slco5a1 34
  • 69 (a)
LOC556735 33
  • 67.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oatp30B 33 34
  • 50.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008711 33
  • 48.88 (n)
(Caenorhabditis elegans)
Secernentea F21G4.1 34
  • 24 (a)
F47E1.4 34
  • 24 (a)
F47E1.2 34
  • 23 (a)
Y32F6B.1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9649 33
Species where no ortholog for SLCO5A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO5A1 Gene

Gene Tree for SLCO5A1 (if available)
Gene Tree for SLCO5A1 (if available)

Paralogs for SLCO5A1 Gene

(13) SIMAP similar genes for SLCO5A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO5A1: view

Variants for SLCO5A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO5A1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000001104 -- 69,775,398(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000008593 -- 69,690,884(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000011643 -- 69,733,336(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000012940 -- 69,676,311(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000038390 -- 69,771,526(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO5A1 Gene

Variant ID Type Subtype PubMed ID
dgv92n68 CNV loss 17160897
esv22621 CNV gain 19812545
esv33249 CNV loss 17666407
esv3617554 CNV loss 21293372
esv5772 CNV gain 19470904
nsv1068714 OTHER inversion 25765185
nsv6244 CNV deletion 18451855

Variation tolerance for SLCO5A1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO5A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Disorders for SLCO5A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLCO5A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mesomelia-synostoses syndrome
  • chromosome 8q13 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO5A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO5A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO5A1 Gene

Publications for SLCO5A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J … NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (PLoS genetics 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The superfamily of organic anion transporting polypeptides. (PMID: 12507753) Hagenbuch B … Meier PJ (Biochimica et biophysica acta 2003) 2 3 58
  5. Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. (PMID: 25301452) Brenner S … Buxhofer-Ausch V (Cancer letters 2015) 3 58

Products for SLCO5A1 Gene

Sources for SLCO5A1 Gene

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