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Aliases for SLCO2B1 Gene

Aliases for SLCO2B1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 2B1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 9 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 2 3 4
  • Organic Anion Transporter B 3 4
  • OATP-RP2 3 4
  • SLC21A9 3 4
  • OATP2B1 3 4
  • OATP-B 3 4
  • OATPB 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 2B1 2
  • Solute Carrier Family 21 Member 9 4
  • KIAA0880 4
  • OATPRP2 4

External Ids for SLCO2B1 Gene

Previous HGNC Symbols for SLCO2B1 Gene

  • SLC21A9

Previous GeneCards Identifiers for SLCO2B1 Gene

  • GC11P074588
  • GC11P074539
  • GC11P074862
  • GC11P071159
  • GC11P074864
  • GC11P074901
  • GC11P074949
  • GC11P075101
  • GC11P075108
  • GC11P075166
  • GC11P075217
  • GC11P075267
  • GC11P075320

Summaries for SLCO2B1 Gene

Entrez Gene Summary for SLCO2B1 Gene

  • This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

GeneCards Summary for SLCO2B1 Gene

SLCO2B1 (Solute Carrier Organic Anion Transporter Family Member 2B1) is a Protein Coding gene. Diseases associated with SLCO2B1 include Persistent Fetal Circulation Syndrome. Among its related pathways are Farnesoid X Receptor Pathway and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot for SLCO2B1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Wiki entry for SLCO2B1 Gene

Additional gene information for SLCO2B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO2B1 Gene

Genomics for SLCO2B1 Gene

GeneHancer (GH) Regulatory Elements for SLCO2B1 Gene

Promoters and enhancers for SLCO2B1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I075154 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.5 +59.8 59757 12 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 ATF7 RXRA SP5 MXD4 SLCO2B1 C2CD3 P4HA3 ENSG00000255395 XRRA1 OR2AT4 ZDHHC20P3
GH11I075149 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 560.7 +51.4 51355 4.3 TFAP4 NFIB ZNF48 TEAD3 ZFHX2 LCORL SCRT2 NR2F6 MAFK EGR2 SLCO2B1 ENSG00000255395 XRRA1 TPBGL ZDHHC20P3
GH11I075100 Enhancer 1.3 Ensembl ENCODE dbSUPER 550.8 +0.0 41 1.2 ATF1 IRF4 POLR2B FOS ATF7 NCOA1 ZNF592 GMEB1 SMARCA4 NBN LOC100421207 SLCO2B1 XRRA1 OR2AT1P ENSG00000255395
GH11I075145 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +46.2 46209 2.9 SMAD5 HLF CEBPG DPF2 ATF4 ZNF316 FOXK2 SCRT2 CEBPA HMBOX1 SLCO2B1 ENSG00000255395 NEU3 TPBGL ARRB1 SPCS2 ZDHHC20P3
GH11I075029 Enhancer 1.5 FANTOM5 Ensembl ENCODE 11 -69.4 -69357 3 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 ZNF766 E2F8 ZNF143 FOS XRRA1 ENSG00000206913 POLD3 RPS3 RNF169 P4HA3 SNORD15B OR2AT4 SLCO2B1 RN7SL239P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO2B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO2B1 gene promoter:

Genomic Locations for SLCO2B1 Gene

Genomic Locations for SLCO2B1 Gene
105,987 bases
Plus strand

Genomic View for SLCO2B1 Gene

Genes around SLCO2B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO2B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO2B1 Gene

Proteins for SLCO2B1 Gene

  • Protein details for SLCO2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 2B1
    Protein Accession:
    Secondary Accessions:
    • A8K2G9
    • B4DGA9
    • B4DTB0
    • E7ERN5
    • E9PPU8
    • Q9H2Z0
    • Q9UFU1

    Protein attributes for SLCO2B1 Gene

    709 amino acids
    Molecular mass:
    76711 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO2B1 Gene


neXtProt entry for SLCO2B1 Gene

Post-translational modifications for SLCO2B1 Gene

  • Glycosylation at isoforms=3, 4176 and isoforms=2, 3, 4538

No data available for DME Specific Peptides for SLCO2B1 Gene

Domains & Families for SLCO2B1 Gene

Gene Families for SLCO2B1 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLCO2B1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO2B1: view

Function for SLCO2B1 Gene

Molecular function for SLCO2B1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Ontology (GO) - Molecular Function for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008514 organic anion transmembrane transporter activity IDA 18501590
GO:0015125 bile acid transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLCO2B1: view
genes like me logo Genes that share phenotypes with SLCO2B1: view

Animal Models for SLCO2B1 Gene

MGI Knock Outs for SLCO2B1:

Animal Model Products

miRNA for SLCO2B1 Gene

miRTarBase miRNAs that target SLCO2B1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLCO2B1 Gene

Localization for SLCO2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO2B1 gene
Compartment Confidence
plasma membrane 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with SLCO2B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO2B1 Gene

Pathways & Interactions for SLCO2B1 Gene

genes like me logo Genes that share pathways with SLCO2B1: view

Interacting Proteins for SLCO2B1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
Selected Interacting proteins: ENSP00000289575 O94956-SO2B1_HUMAN for SLCO2B1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015721 bile acid and bile salt transport IBA --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO2B1: view

No data available for SIGNOR curated interactions for SLCO2B1 Gene

Drugs & Compounds for SLCO2B1 Gene

(47) Drugs for SLCO2B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyburide Approved Pharma Channel blocker, Transporter, substrate, blocker Kir6 (KATP) channel blocker 116
Montelukast Approved Pharma Antagonist, Transporter, substrate 280
Fexofenadine Approved, Investigational Pharma Transporter, substrate 66
Ergoloid mesylate Approved Pharma Target, inhibitor 0
Estradiol Approved, Investigational, Vet_approved Pharma Transporter, inhibitor Sex hormone 1400

(6) Additional Compounds for SLCO2B1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Thromboxane B2
  • TXB2

(1) ApexBio Compounds for SLCO2B1 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO2B1: view

Drug Products

Transcripts for SLCO2B1 Gene

Unigene Clusters for SLCO2B1 Gene

Solute carrier organic anion transporter family, member 2B1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2B1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -

Relevant External Links for SLCO2B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO2B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO2B1 Gene

This gene is overexpressed in Liver (x6.8).

Protein differential expression in normal tissues from HIPED for SLCO2B1 Gene

This gene is overexpressed in Heart (19.8), Gallbladder (10.1), Fetal Liver (10.0), and Liver (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO2B1 Gene

Protein tissue co-expression partners for SLCO2B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLCO2B1 Gene:


SOURCE GeneReport for Unigene cluster for SLCO2B1 Gene:


mRNA Expression by UniProt/SwissProt for SLCO2B1 Gene:

Tissue specificity: Isoform 1 has its highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.

Evidence on tissue expression from TISSUES for SLCO2B1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Intestine(2.8)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with SLCO2B1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO2B1 Gene

Orthologs for SLCO2B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO2B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO2B1 33 34
  • 99.44 (n)
(Canis familiaris)
Mammalia SLCO2B1 33 34
  • 85.33 (n)
(Bos Taurus)
Mammalia SLCO2B1 33 34
  • 84.93 (n)
(Rattus norvegicus)
Mammalia Slco2b1 33
  • 80.42 (n)
(Mus musculus)
Mammalia Slco2b1 33 16 34
  • 79.77 (n)
(Monodelphis domestica)
Mammalia SLCO2B1 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
(Gallus gallus)
Aves SLCO2B1 33 34
  • 63.2 (n)
(Anolis carolinensis)
Reptilia SLCO2B1 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco2b1 33
  • 61.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15841 33
(Danio rerio)
Actinopterygii slco2b1 33 34
  • 55.06 (n)
(Caenorhabditis elegans)
Secernentea F21G4.1 33
  • 41.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for SLCO2B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO2B1 Gene

Gene Tree for SLCO2B1 (if available)
Gene Tree for SLCO2B1 (if available)

Paralogs for SLCO2B1 Gene

Variants for SLCO2B1 Gene

Sequence variations from dbSNP and Humsavar for SLCO2B1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_036412 A breast cancer sample p.Glu77Lys
rs1000000178 -- 75,189,846(+) A/C intron_variant
rs1000002586 -- 75,190,438(+) C/G intron_variant
rs1000065032 -- 75,163,493(+) A/G intron_variant
rs1000070990 -- 75,158,123(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO2B1 Gene

Variant ID Type Subtype PubMed ID
nsv1054122 CNV loss 25217958
nsv1134156 CNV deletion 24896259

Variation tolerance for SLCO2B1 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.46; 85.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO2B1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Disorders for SLCO2B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLCO2B1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO2B1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO2B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO2B1 Gene

Publications for SLCO2B1 Gene

  1. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PMID: 15226675) Niemi M … Kivistö KT (Pharmacogenetics 2004) 3 22 44 58
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I … Tsuji A (Biochemical and biophysical research communications 2000) 3 4 25 58
  3. Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant. (PMID: 23531488) Knauer MJ … Tirona RG (Molecular pharmacology 2013) 3 4 58
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  5. Impact of regulatory polymorphisms in organic anion transporter genes in the human liver. (PMID: 19620935) Aoki M … Inui K (Pharmacogenetics and genomics 2009) 3 44 58

Products for SLCO2B1 Gene

Sources for SLCO2B1 Gene

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