This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010] See more...

Aliases for SLCO2B1 Gene

Aliases for SLCO2B1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 2B1 2 3 4 5
  • OATP2B1 2 3 4
  • OATP-B 2 3 4
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 9 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 2 3 4
  • Organic Anion Transporter B 3 4
  • OATP-RP2 3 4
  • SLC21A9 3 4
  • OATPB 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 2B1 2
  • Solute Carrier Family 21 Member 9 4
  • KIAA0880 4
  • SLCO2B1 5
  • OATPRP2 4

External Ids for SLCO2B1 Gene

Previous HGNC Symbols for SLCO2B1 Gene

  • SLC21A9

Previous GeneCards Identifiers for SLCO2B1 Gene

  • GC11P074588
  • GC11P074539
  • GC11P074862
  • GC11P071159
  • GC11P074864
  • GC11P074901
  • GC11P074949
  • GC11P075101
  • GC11P075540
  • GC11P075595
  • GC11P075600
  • GC11P075718
  • GC11P075108
  • GC11P075166
  • GC11P075217
  • GC11P075267
  • GC11P075320
  • GC11P075374
  • GC11P075432
  • GC11P075484
  • GC11P075835
  • GC11P075955

Summaries for SLCO2B1 Gene

Entrez Gene Summary for SLCO2B1 Gene

  • This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

GeneCards Summary for SLCO2B1 Gene

SLCO2B1 (Solute Carrier Organic Anion Transporter Family Member 2B1) is a Protein Coding gene. Diseases associated with SLCO2B1 include Bronchiectasis 3 and Ileum Cancer. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot Summary for SLCO2B1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Wiki entry for SLCO2B1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLCO2B1 Gene

Genomics for SLCO2B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLCO2B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLCO2B1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLCO2B1

Top Transcription factor binding sites by QIAGEN in the SLCO2B1 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • Sp1

Genomic Locations for SLCO2B1 Gene

Latest Assembly
chr11:75,100,563-75,206,549
(GRCh38/hg38)
Size:
105,987 bases
Orientation:
Plus strand

Previous Assembly
chr11:74,862,152-74,917,594
(GRCh37/hg19 by Entrez Gene)
Size:
55,443 bases
Orientation:
Plus strand

chr11:74,811,608-74,917,594
(GRCh37/hg19 by Ensembl)
Size:
105,987 bases
Orientation:
Plus strand

Genomic View for SLCO2B1 Gene

Genes around SLCO2B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO2B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO2B1 Gene

Proteins for SLCO2B1 Gene

  • Protein details for SLCO2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94956-SO2B1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 2B1
    Protein Accession:
    O94956
    Secondary Accessions:
    • A8K2G9
    • B4DGA9
    • B4DTB0
    • E7ERN5
    • E9PPU8
    • Q9H2Z0
    • Q9UFU1

    Protein attributes for SLCO2B1 Gene

    Size:
    709 amino acids
    Molecular mass:
    76711 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74903.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.

    Alternative splice isoforms for SLCO2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO2B1 Gene

Post-translational modifications for SLCO2B1 Gene

  • Glycosylation at Asn176 and Asn538
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO2B1 Gene

Domains & Families for SLCO2B1 Gene

Gene Families for SLCO2B1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLCO2B1 Gene

InterPro:
Blocks:
  • Organic anion transporter polypeptide (OATP), N-terminal

Suggested Antigen Peptide Sequences for SLCO2B1 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier organic anion transporter family, member 2B1 (C7BWB7_HUMAN)
  • Solute carrier family 21 member 9 (SO2B1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94956

UniProtKB/Swiss-Prot:

SO2B1_HUMAN :
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO2B1: view

Function for SLCO2B1 Gene

Molecular function for SLCO2B1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Ontology (GO) - Molecular Function for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008514 organic anion transmembrane transporter activity IDA 12724351
GO:0015125 bile acid transmembrane transporter activity IBA 21873635
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLCO2B1: view
genes like me logo Genes that share phenotypes with SLCO2B1: view

Animal Models for SLCO2B1 Gene

MGI Knock Outs for SLCO2B1:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLCO2B1

miRNA for SLCO2B1 Gene

miRTarBase miRNAs that target SLCO2B1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO2B1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLCO2B1 Gene

Localization for SLCO2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO2B1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane ISS 18619525
genes like me logo Genes that share ontologies with SLCO2B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO2B1 Gene

Pathways & Interactions for SLCO2B1 Gene

genes like me logo Genes that share pathways with SLCO2B1: view

Interacting Proteins for SLCO2B1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000289575 O94956-SO2B1_HUMAN for SLCO2B1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006811 ion transport IEA --
GO:0015711 organic anion transport IDA 12724351
GO:0015721 bile acid and bile salt transport IBA 21873635
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO2B1: view

No data available for SIGNOR curated interactions for SLCO2B1 Gene

Drugs & Compounds for SLCO2B1 Gene

(80) Drugs for SLCO2B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyburide Approved Pharma Inhibitor, Inhibition, Transporter, substrate, blocker Kir6 (KATP) channel blocker 126
Montelukast Approved Pharma Transporter, substrate 321
Gemfibrozil Approved Pharma Inhibitor, Inhibition, Target, activator 31
Fexofenadine Approved, Investigational Pharma Transporter, substrate 79
acetic acid Approved Pharma Transporter, substrate, inhibitor 151

(5) Additional Compounds for SLCO2B1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Thromboxane B2
  • TXB2
  • b2, Thromboxane
54397-85-2

(1) ApexBio Compounds for SLCO2B1 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO2B1: view

Drug products for research

Transcripts for SLCO2B1 Gene

mRNA/cDNA for SLCO2B1 Gene

3 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO2B1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2B1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6:
SP7:

Relevant External Links for SLCO2B1 Gene

GeneLoc Exon Structure for
SLCO2B1

Expression for SLCO2B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO2B1 Gene

This gene is overexpressed in Liver (x6.8).

Protein differential expression in normal tissues from HIPED for SLCO2B1 Gene

This gene is overexpressed in Heart (19.8), Gallbladder (10.1), Fetal Liver (10.0), and Liver (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO2B1 Gene



Protein tissue co-expression partners for SLCO2B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLCO2B1

SOURCE GeneReport for Unigene cluster for SLCO2B1 Gene:

Hs.7884

mRNA Expression by UniProt/SwissProt for SLCO2B1 Gene:

O94956-SO2B1_HUMAN
Tissue specificity: Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.

Evidence on tissue expression from TISSUES for SLCO2B1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Intestine(2.9)
  • Kidney(2.7)
  • Adrenal gland(2.2)
  • Blood(2.2)
  • Spleen(2.2)
  • Lung(2.2)
  • Heart(2.1)
  • Gall bladder(2.1)
  • Thyroid gland(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with SLCO2B1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO2B1 Gene

Orthologs for SLCO2B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO2B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLCO2B1 29 30
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLCO2B1 29 30
  • 85.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLCO2B1 29 30
  • 84.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slco2b1 29
  • 80.42 (n)
Mouse
(Mus musculus)
Mammalia Slco2b1 29 16 30
  • 79.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLCO2B1 30
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 54 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SLCO2B1 29 30
  • 63.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLCO2B1 30
  • 49 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slco2b1 29
  • 61.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15841 29
Zebrafish
(Danio rerio)
Actinopterygii slco2b1 29 30
  • 55.06 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F21G4.1 29
  • 41.74 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 25 (a)
OneToMany
Species where no ortholog for SLCO2B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLCO2B1 Gene

ENSEMBL:
Gene Tree for SLCO2B1 (if available)
TreeFam:
Gene Tree for SLCO2B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLCO2B1: view image
Alliance of Genome Resources:
Additional Orthologs for SLCO2B1

Paralogs for SLCO2B1 Gene

(13) SIMAP similar genes for SLCO2B1 Gene using alignment to 11 proteins:

  • SO2B1_HUMAN
  • C7BWB6_HUMAN
  • C7BWB7_HUMAN
  • E7ERN5_HUMAN
  • E9PI53_HUMAN
  • E9PIU9_HUMAN
  • E9PN87_HUMAN
  • E9PPJ4_HUMAN
  • E9PPU8_HUMAN
  • E9PRW4_HUMAN
  • H0YE11_HUMAN
genes like me logo Genes that share paralogs with SLCO2B1: view

Variants for SLCO2B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLCO2B1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1109407 Benign: not provided 75,165,906(+) G/A
NM_007256.5(SLCO2B1):c.405G>A (p.Pro135=)
SYNONYMOUS_VARIANT,INTRON
rs138677494 Benign: not provided 75,163,968(+) C/T
NM_007256.5(SLCO2B1):c.153C>T (p.Phe51=)
SYNONYMOUS_VARIANT,INTRON
rs144302377 Benign: not provided 75,193,429(+) C/T
NM_007256.5(SLCO2B1):c.1287C>T (p.Gly429=)
SYNONYMOUS
rs57141326 Benign: not provided 75,204,541(+) G/A
NM_007256.5(SLCO2B1):c.2091G>A (p.Val697=)
SYNONYMOUS
rs59305495 Likely Benign: not provided 75,196,592(+) C/T
NM_007256.5(SLCO2B1):c.1512C>T (p.Cys504=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLCO2B1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLCO2B1 Gene

Variant ID Type Subtype PubMed ID
nsv1054122 CNV loss 25217958
nsv1134156 CNV deletion 24896259

Variation tolerance for SLCO2B1 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.46; 85.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO2B1 Gene

Human Gene Mutation Database (HGMD)
SLCO2B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO2B1
Leiden Open Variation Database (LOVD)
SLCO2B1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Disorders for SLCO2B1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLCO2B1 Gene - From: COP

Disorder Aliases PubMed IDs
bronchiectasis 3
ileum cancer
  • ileal neoplasm
folate malabsorption, hereditary
  • hereditary folate malabsorption
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO2B1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLCO2B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO2B1 Gene

Publications for SLCO2B1 Gene

  1. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PMID: 15226675) Niemi M … Kivistö KT (Pharmacogenetics 2004) 3 22 40
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I … Tsuji A (Biochemical and biophysical research communications 2000) 3 4 25
  3. Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant. (PMID: 23531488) Knauer MJ … Tirona RG (Molecular pharmacology 2013) 3 4
  4. Transcriptional control of human organic anion transporting polypeptide 2B1 gene. (PMID: 19383542) Pomari E … Dalla Valle L (The Journal of steroid biochemistry and molecular biology 2009) 3 22
  5. Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. (PMID: 19151602) Mougey EB … Lima JJ (Pharmacogenetics and genomics 2009) 22 25

Products for SLCO2B1 Gene

Sources for SLCO2B1 Gene