Aliases for SLCO1C1 Gene
Aliases for SLCO1C1 Gene
- Solute Carrier Organic Anion Transporter Family Member 1C1 2 3 3 5
- Solute Carrier Family 21 (Organic Anion Transporter), Member 14 2 3
- Organic Anion Transporter Polypeptide-Related Protein 5 3 4
- Solute Carrier Family 21 Member 14 3 4
- Organic Anion Transporter F 3 4
- Thyroxine Transporter 3 4
- SLC21A14 3 4
- OAT-RP-5 3 4
- OATP-14 3 4
- OATP1C1 3 4
External Ids for SLCO1C1 Gene
- HGNC: 13819
- Entrez Gene: 53919
- Ensembl: ENSG00000139155
- OMIM: 613389
- UniProtKB: Q9NYB5
Previous HGNC Symbols for SLCO1C1 Gene
- SLC21A14
Previous GeneCards Identifiers for SLCO1C1 Gene
- GC12P020739
- GC12P020848
- GC12P020620
Summaries for SLCO1C1 Gene
-
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
GeneCards Summary for SLCO1C1 Gene
SLCO1C1 (Solute Carrier Organic Anion Transporter Family Member 1C1) is a Protein Coding gene. Diseases associated with SLCO1C1 include Allan-Herndon-Dudley Syndrome and Chronic Cholangitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SLCO1B3.
UniProtKB/Swiss-Prot for SLCO1C1 Gene
-
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).
Additional gene information for SLCO1C1 Gene
- Monarch Initiative
- Search for SLCO1C1 at DataMed
- Search for SLCO1C1 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1C1 Gene
Genomics for SLCO1C1 Gene
GeneHancer (GH) Regulatory Elements for SLCO1C1 Gene
Promoters and enhancers for SLCO1C1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J020695 | Promoter | 0.5 | EPDnew | 650.7 | +0.1 | 106 | 0.1 | SLCO1C1 GC12M020713 | ||
| GH12J020626 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 11 | -66.6 | -66627 | 4.4 | FOXA2 DNMT3B THRB RARA CREM RXRA SP5 USF2 MXD4 REST | SLCO1C1 SLCO1B7 PDE3A GC12P020633 GC12P020604 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLCO1C1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLCO1C1 gene promoter:
-
- N-Myc
- Evi-1
- MIF-1
- AML1a
- HNF-3beta
- C/EBPalpha
- RFX1
- POU2F1
Regulatory Element Products
Genomic Locations for SLCO1C1 Gene
Genomic Locations for SLCO1C1 Gene
- chr12:20,695,355-20,753,386
- (GRCh38/hg38)
- Size:
- 58,032 bases
- Orientation:
- Plus strand
- chr12:20,848,289-20,906,320
- (GRCh37/hg19)
- Size:
- 58,032 bases
- Orientation:
- Plus strand
Genomic View for SLCO1C1 Gene
Genes around SLCO1C1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.2 by Entrez Gene
- 12p12.2 by HGNC
- 12p12.2 by Ensembl
SLCO1C1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLCO1C1 Gene
Proteins for SLCO1C1 Gene
-
Protein details for SLCO1C1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYB5-SO1C1_HUMAN
- Recommended name:
- Solute carrier organic anion transporter family member 1C1
- Protein Accession:
- Q9NYB5
- B7Z251
- B7Z3Q3
- B7Z8P1
- F5GZD6
- Q5JPA4
Protein attributes for SLCO1C1 Gene
- Size:
- 712 amino acids
- Molecular mass:
- 78696 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for SLCO1C1 Gene
Other Protein References for SLCO1C1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SLCO1C1
- Novus Biologicals Antibodies for SLCO1C1
-
Abcam antibodies for SLCO1C1
- Invitrogen Antibodies for SLCO1C1 (AFLGC-SLCO1C1)
- GeneTex SLCO1C1 Antibody for SLCO1C1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLCO1C1
Protein Products
-
OriGene Purified Proteins for SLCO1C1
- Search Origene for MassSpec and Protein Over-expression Lysates for SLCO1C1
- Origene Custom Protein Services for SLCO1C1
- Novus Biologicals lysates for SLCO1C1
- antibodies-online: Search results for 4 available SLCO1C1 Proteins ranked by validation data
- Compare Top SLCO1C1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SLCO1C1
Assay Products
No data available for DME Specific Peptides for SLCO1C1 Gene
Domains & Families for SLCO1C1 Gene
Gene Families for SLCO1C1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLCO1C1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLCO1C1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NYB5- Family:
-
- Belongs to the organo anion transporter (TC 2.A.60) family.
Function for SLCO1C1 Gene
Molecular function for SLCO1C1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).
Phenotypes From GWAS Catalog for SLCO1C1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO:0008514 | organic anion transmembrane transporter activity | IEA | -- |
| GO:0015125 | bile acid transmembrane transporter activity | IBA | -- |
| GO:0015347 | sodium-independent organic anion transmembrane transporter activity | IBA | -- |
| GO:0015349 | thyroid hormone transmembrane transporter activity | TAS | -- |
Phenotypes for SLCO1C1 Gene
- MGI mutant phenotypes for SLCO1C1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SLCO1C1:
Animal Models for SLCO1C1 Gene
- MGI Knock Outs for SLCO1C1:
-
- Slco1c1 Slco1c1<tm1.1Arte>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLCO1C1
-
CRISPR Products
-
OriGene CRISPR knockouts for SLCO1C1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLCO1C1
- genomics-online: gRNA clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLCO1C1
- Browse OriGene Inhibitory RNA Products For SLCO1C1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO1C1
- genomics-online: shRNA clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for SLCO1C1
- RC205194
- RC205194L1
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- RC205194L3
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- RC226723
- RC226723L1
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- RC226723L4
- RC226774
- RC226774L1
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- RC226774L3
- RC226774L4
- RC226796
- RC226796L1
- RC226796L2
- RC226796L3
- RC226796L4
- RG205194
- RG226723
- RG226774
- RG226796
- RC205194L1V
- RC205194L2V
- RC205194L3V
- RC205194L4V
- RC226723L1V
- RC226723L2V
- RC226723L3V
- RC226723L4V
- RC226774L1V
- RC226774L2V
- RC226774L3V
- RC226774L4V
- RC226796L1V
- RC226796L2V
- RC226796L3V
- RC226796L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLCO1C1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLCO1C1
- genomics-online: cdna clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
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- Overview of 109 available SLCO1C1 gene related products
-
Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SLCO1C1 (SLCO1C1/OATP1C1)
Cell Line Products
-
Horizon Cell Lines for SLCO1C1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1C1 Gene
Localization for SLCO1C1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLCO1C1 Gene
- Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO1C1 Gene
Pathways & Interactions for SLCO1C1 Gene
Pathways by source for SLCO1C1 Gene
1 BioSystems pathway for SLCO1C1 Gene
1 KEGG pathway for SLCO1C1 Gene
2 R&D Systems pathways for SLCO1C1 Gene
Interacting Proteins for SLCO1C1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0015711 | organic anion transport | IEA | -- |
| GO:0015721 | bile acid and bile salt transport | IEA | -- |
| GO:0043252 | sodium-independent organic anion transport | TAS | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLCO1C1 Gene
Drugs & Compounds for SLCO1C1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Probenecid | Approved, Investigational | Pharma | Inhibition, Inhibitor, Activator, blocker, Transporter, inhibitor | 35 | ||
| Levothyroxine | Approved | Pharma | Transporter, substrate | 0 | ||
| Meclofenamic acid | Approved, Vet_approved | Pharma | Transporter, inhibitor | 2 | ||
| Methotrexate | Approved | Pharma | Transporter, substrate | Folate antagonist,inhibits DFHR | 1603 | |
| Ouabain | Approved | Pharma | Transporter, substrate | Na+/K+ ATPase inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| TCA |
|
Inhibition, Inhibitor |
|
|
||
| 3',4'-Dihydrodiol |
|
|
||||
| 4'-Hydroxydiclofenac |
|
64118-84-9 |
Drug Products
Transcripts for SLCO1C1 Gene
mRNA/cDNA for SLCO1C1 Gene
- (15) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000534996 557 bps (uc058ltg.1)
- ENST00000539415 2414 bps (uc058lth.1)
- ENST00000540354 2529 bps (uc010sij.3)
- ENST00000266509 3365 bps (uc001rei.3)
- ENST00000545604 2557 bps (uc010sii.3)
Unigene Clusters for SLCO1C1 Gene
- Solute carrier organic anion transporter family, member 1C1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SLCO1C1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLCO1C1
- genomics-online: gRNA clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLCO1C1
- GenScript: Design CRISPR guide RNA sequences for SLCO1C1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLCO1C1
- Browse OriGene Inhibitory RNA Products For SLCO1C1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO1C1
- genomics-online: shRNA clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for SLCO1C1
- RC205194
- RC205194L1
- RC205194L2
- RC205194L3
- RC205194L4
- RC226723
- RC226723L1
- RC226723L2
- RC226723L3
- RC226723L4
- RC226774
- RC226774L1
- RC226774L2
- RC226774L3
- RC226774L4
- RC226796
- RC226796L1
- RC226796L2
- RC226796L3
- RC226796L4
- RG205194
- RG226723
- RG226774
- RG226796
- RC205194L1V
- RC205194L2V
- RC205194L3V
- RC205194L4V
- RC226723L1V
- RC226723L2V
- RC226723L3V
- RC226723L4V
- RC226774L1V
- RC226774L2V
- RC226774L3V
- RC226774L4V
- RC226796L1V
- RC226796L2V
- RC226796L3V
- RC226796L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLCO1C1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLCO1C1
- genomics-online: cdna clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
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- Overview of 109 available SLCO1C1 gene related products
-
Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SLCO1C1 (SLCO1C1/OATP1C1)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Expression for SLCO1C1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Meninges
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Neural Tube (Nervous System)
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for SLCO1C1 Gene
This gene is overexpressed in Brain - Caudate (basal ganglia) (x7.9), Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Putamen (basal ganglia) (x6.1), Brain - Amygdala (x6.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Cortex (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of SLCO1C1 Gene:
SLCO1C1SOURCE GeneReport for Unigene cluster for SLCO1C1 Gene:
Hs.47261mRNA Expression by UniProt/SwissProt for SLCO1C1 Gene:
Q9NYB5-SO1C1_HUMAN
Tissue specificity:
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
Evidence on tissue expression from TISSUES for SLCO1C1 Gene
- Nervous system(4.6)
- Kidney(4.3)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for SLCO1C1
-
OriGene qPCR primer pairs and template standards for SLCO1C1
- genomics-online: primer clones - Search results for 109 available SLCO1C1 gene related products
- Overview of 109 available SLCO1C1 gene related products
-
Recommended
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO1C1 Gene
Orthologs for SLCO1C1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLCO1C1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SLCO1C1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SLCO1C1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Slco1c1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Slco1c1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLCO1C1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLCO1C1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SLCO1C1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slco1c1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | slco1c1 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12238 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1414 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany |
- Species where no ortholog for SLCO1C1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SLCO1C1 Gene
- ENSEMBL:
- Gene Tree for SLCO1C1 (if available)
- TreeFam:
- Gene Tree for SLCO1C1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLCO1C1: view image
Paralogs for SLCO1C1 Gene
Paralogs for SLCO1C1 Gene
(12) SIMAP similar genes for SLCO1C1 Gene using alignment to 3 proteins:
- SO1C1_HUMAN
- F5H6S4_HUMAN
- L8EC48_HUMAN
Variants for SLCO1C1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011778 | -- | 20,705,057(+) | T/C | intron_variant | |
| rs1000112154 | -- | 20,751,636(+) | C/T | intron_variant | |
| rs1000159764 | -- | 20,728,617(+) | G/T | intron_variant | |
| rs1000187242 | -- | 20,722,125(+) | C/G | intron_variant | |
| rs1000270200 | -- | 20,729,585(+) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv779n106 | CNV | deletion | 24896259 |
| esv2037706 | CNV | deletion | 18987734 |
| esv24973 | CNV | gain | 19812545 |
| esv2532269 | CNV | deletion | 19546169 |
| esv2659248 | CNV | deletion | 23128226 |
| esv2745622 | CNV | deletion | 23290073 |
| esv3548860 | CNV | deletion | 23714750 |
| esv3580174 | CNV | loss | 25503493 |
| esv3580175 | CNV | loss | 25503493 |
| esv3591 | CNV | loss | 18987735 |
| esv3628788 | CNV | gain | 21293372 |
| esv3628789 | CNV | loss | 21293372 |
| esv7360 | CNV | loss | 19470904 |
| esv990517 | CNV | deletion | 20482838 |
| nsv1039951 | CNV | loss | 25217958 |
| nsv1051454 | CNV | loss | 25217958 |
| nsv1054997 | CNV | gain | 25217958 |
| nsv1070515 | CNV | deletion | 25765185 |
| nsv1159988 | CNV | duplication | 26073780 |
| nsv523367 | CNV | loss | 19592680 |
| nsv557704 | CNV | gain | 21841781 |
| nsv635 | CNV | insertion | 18451855 |
| nsv826279 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.61;
97.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLCO1C1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1C1 Gene
Disorders for SLCO1C1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| allan-herndon-dudley syndrome |
|
|
| chronic cholangitis |
|
|
Search SLCO1C1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLCO1C1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO1C1 Gene
Publications for SLCO1C1 Gene
- Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. (PMID: 18687783) Roberts LM … Zerangue N (Endocrinology 2008) 3 4 22 58
- Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation. (PMID: 18566113) van der Deure WM … Visser TJ (Endocrinology 2008) 3 22 44 58
- Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. (PMID: 12351693) Pizzagalli F … Meier PJ (Molecular endocrinology (Baltimore, Md.) 2002) 3 4 25 58
- Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 44 58
- Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. (PMID: 18845642) Westholm DE … Anderson GW (Endocrinology 2009) 3 25 58
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Sources for SLCO1C1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
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- (7) GeneLoc
- (8) Gene Wiki
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- (32) SOURCE
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- (34) PanEnsembl
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- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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