SLCO1C1 Gene (Protein Coding)

Solute Carrier Organic Anion Transporter Family Member 1C1

GC12P020695
GIFtS:
40
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may b... See more...

Aliases for SLCO1C1 Gene

Aliases for SLCO1C1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1C1 2 3 4 5
  • OATP1C1 2 3 4
  • OATP-F 2 3 4
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 14 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 5 3 4
  • Solute Carrier Family 21 Member 14 3 4
  • Organic Anion Transporter F 3 4
  • Thyroxine Transporter 3 4
  • SLC21A14 3 4
  • OAT-RP-5 3 4
  • OATPRP5 3 4
  • OATP-14 3 4
  • OATP14 3 4
  • OATP1 2 3
  • OATPF 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 1C1 2
  • Organic Anion Transporting Polypeptide 14 3
  • Organic Anion-Transporting Polypeptide 14 4
  • SLCO1C1 5

External Ids for SLCO1C1 Gene

Previous HGNC Symbols for SLCO1C1 Gene

  • SLC21A14

Previous GeneCards Identifiers for SLCO1C1 Gene

  • GC12P020739
  • GC12P020848
  • GC12P020620

Summaries for SLCO1C1 Gene

Entrez Gene Summary for SLCO1C1 Gene

  • This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO1C1 Gene

SLCO1C1 (Solute Carrier Organic Anion Transporter Family Member 1C1) is a Protein Coding gene. Diseases associated with SLCO1C1 include Allan-Herndon-Dudley Syndrome and Hyperthyroidism. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SLCO1B3.

UniProtKB/Swiss-Prot Summary for SLCO1C1 Gene

  • Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity).

Additional gene information for SLCO1C1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLCO1C1 Gene

Genomics for SLCO1C1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SLCO1C1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J020695 Promoter 0.8 EPDnew Ensembl 606.4 +14.3 14300 1.4 REST SLCO1C1 lnc-SLCO1C1-1 RF00994-219 SLCO1B3
GH12J020681 Enhancer 0.5 Ensembl 600.7 -0.5 -499 0.2 CTCF USF1 RAD21 MYC MAX SLCO1C1 lnc-SLCO1C1-2 piR-41525-121 PDE3A
GH12J020626 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.1 -53.1 -53072 4.4 GATAD2A TFE3 SOX13 RBFOX2 RXRB CEBPA CEBPB TCF7 SP1 FOXA2 SLCO1C1 PDE3A piR-38959-006 piR-52916-007
GH12J020656 Enhancer 0.7 Ensembl 16.1 -24.5 -24500 1.4 GATAD2A SOX13 RXRB IRF2 TCF7 ZKSCAN8 FOXA2 KDM6A CREM FOXP1 SLCO1C1 piR-38959-006 piR-52916-007 PDE3A
GH12J019694 Enhancer 0.7 Ensembl ENCODE 9.4 -986.4 -986442 1.7 ATF7 CEBPB ATF2 CEBPG JUND MYC POLR2A RNU1-146P SLCO1C1 LINC02398 lnc-PLEKHA5-4 RF00003-019 AEBP2 PDE3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLCO1C1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLCO1C1

Top Transcription factor binding sites by QIAGEN in the SLCO1C1 gene promoter:
  • AML1a
  • C/EBPalpha
  • Evi-1
  • HNF-3beta
  • MIF-1
  • N-Myc
  • POU2F1
  • RFX1

Genomic Locations for SLCO1C1 Gene

Genomic Locations for SLCO1C1 Gene
chr12:20,681,800-20,753,386
(GRCh38/hg38)
Size:
71,587 bases
Orientation:
Plus strand
chr12:20,848,289-20,906,320
(GRCh37/hg19)
Size:
58,032 bases
Orientation:
Plus strand

Genomic View for SLCO1C1 Gene

Genes around SLCO1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1C1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLCO1C1 Gene

Proteins for SLCO1C1 Gene

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  • Protein details for SLCO1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYB5-SO1C1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1C1
    Protein Accession:
    Q9NYB5
    Secondary Accessions:
    • B7Z251
    • B7Z3Q3
    • B7Z8P1
    • F5GZD6
    • Q5JPA4

    Protein attributes for SLCO1C1 Gene

    Size:
    712 amino acids
    Molecular mass:
    78696 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO1C1 Gene

Post-translational modifications for SLCO1C1 Gene

  • Glycosylation at Asn146, Asn510, Asn520, and Asn533
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO1C1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO1C1 Gene

Domains & Families for SLCO1C1 Gene

Gene Families for SLCO1C1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLCO1C1 Gene

InterPro:
Blocks:
  • Protease inhibitor, Kazal-type
  • Organic anion transporter polypeptide (OATP), N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SLCO1C1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56816, highly similar to Solute carrier organic anion transporte rfamily member 1C1 (B7Z3Q3_HUMAN)
  • Thyroxine transporter (SO1C1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYB5

UniProtKB/Swiss-Prot:

SO1C1_HUMAN :
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1C1: view

Function for SLCO1C1 Gene

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Molecular function for SLCO1C1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity).

Phenotypes From GWAS Catalog for SLCO1C1 Gene

Gene Ontology (GO) - Molecular Function for SLCO1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA --
GO:0015125 bile acid transmembrane transporter activity IBA 21873635
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA 21873635
GO:0015349 thyroid hormone transmembrane transporter activity IDA 12351693
genes like me logo Genes that share ontologies with SLCO1C1: view
genes like me logo Genes that share phenotypes with SLCO1C1: view

Animal Models for SLCO1C1 Gene

MGI Knock Outs for SLCO1C1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

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Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1C1 Gene

Localization for SLCO1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1C1 Gene

Cell membrane. Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO1C1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLCO1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 18687783
genes like me logo Genes that share ontologies with SLCO1C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO1C1 Gene

Pathways & Interactions for SLCO1C1 Gene

genes like me logo Genes that share pathways with SLCO1C1: view

Interacting Proteins for SLCO1C1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000444149 Q9NYB5-SO1C1_HUMAN for SLCO1C1 Gene via STRING IID

GPS-Prot Interaction Network for SLCO1C1

Gene Ontology (GO) - Biological Process for SLCO1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015711 organic anion transport IEA --
GO:0015721 bile acid and bile salt transport IBA 21873635
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport IDA 12351693
genes like me logo Genes that share ontologies with SLCO1C1: view

No data available for SIGNOR curated interactions for SLCO1C1 Gene

Drugs & Compounds for SLCO1C1 Gene

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(28) Drugs for SLCO1C1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved, Investigational Pharma Inhibitor, Inhibition, Activator, Transporter, inhibitor, blocker 40
Taurocholic acid Approved, Experimental Pharma Transporter, substrate, inhibitor 0
Levothyroxine Approved Pharma Transporter, substrate, inhibitor 0
Meclofenamic acid Approved, Vet_approved Pharma Transporter, inhibitor 2
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR 1825

(3) Additional Compounds for SLCO1C1 Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TCA
Inhibitor, Inhibition
3',4'-Dihydrodiol
4'-Hydroxydiclofenac
  • (O-(2,6-dichloro-4-hydroxyanilino)Phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-dichloro-4-hydroxyanilino)Phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
 64118-84-9

(1) ApexBio Compounds for SLCO1C1 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO1C1: view

Drug Products

Transcripts for SLCO1C1 Gene

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mRNA/cDNA for SLCO1C1 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO1C1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1C1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2:
SP3: - - -
SP4: -

Relevant External Links for SLCO1C1 Gene

GeneLoc Exon Structure for
SLCO1C1

Expression for SLCO1C1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO1C1 Gene

mRNA expression in normal human tissues for SLCO1C1 Gene
mRNA expression by BioGPS for SLCO1C1 GenemRNA expression by GTEx for SLCO1C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1C1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x7.9), Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Putamen (basal ganglia) (x6.1), Brain - Amygdala (x6.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Cortex (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLCO1C1

SOURCE GeneReport for Unigene cluster for SLCO1C1 Gene:

Hs.47261

mRNA Expression by UniProt/SwissProt for SLCO1C1 Gene:

Q9NYB5-SO1C1_HUMAN
Tissue specificity: Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.

Evidence on tissue expression from TISSUES for SLCO1C1 Gene

  • Nervous system(4.7)
  • Kidney(4.4)
  • Thyroid gland(2.6)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with SLCO1C1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO1C1 Gene

Orthologs for SLCO1C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1C1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SLCO1C1 30 31
  • 99.64 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SLCO1C1 30 31
  • 90.26 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SLCO1C1 30 31
  • 89.27 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Slco1c1 30
  • 84.36 (n)
Mouse
(Mus musculus)
 Mammalia Slco1c1 30 17 31
  • 84.25 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SLCO1C1 31
  • 40 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SLCO1C1 30 31
  • 72.25 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SLCO1C1 31
  • 66 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia slco1c1 30
  • 65.71 (n)
Zebrafish
(Danio rerio)
 Actinopterygii slco1c1 30 31
  • 62.5 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12238 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.1414 31
  • 31 (a)
 OneToMany
-- 31
  • 28 (a)
 OneToMany
Species where no ortholog for SLCO1C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLCO1C1 Gene

ENSEMBL:
Gene Tree for SLCO1C1 (if available)
TreeFam:
Gene Tree for SLCO1C1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLCO1C1: view image

Paralogs for SLCO1C1 Gene

Paralogs for SLCO1C1 Gene

(12) SIMAP similar genes for SLCO1C1 Gene using alignment to 3 proteins:

  • SO1C1_HUMAN
  • F5H6S4_HUMAN
  • L8EC48_HUMAN
genes like me logo Genes that share paralogs with SLCO1C1: view

Variants for SLCO1C1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLCO1C1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
710132 Benign: not provided 20,740,175(+) G/T INTRON_VARIANT
716429 Benign: not provided 20,733,007(+) T/C SYNONYMOUS_VARIANT
786793 Benign: not provided 20,740,325(+) A/G MISSENSE_VARIANT
790367 Benign: not provided 20,723,234(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SLCO1C1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLCO1C1 Gene

Variant ID Type Subtype PubMed ID
dgv779n106 CNV deletion 24896259
esv2037706 CNV deletion 18987734
esv24973 CNV gain 19812545
esv2532269 CNV deletion 19546169
esv2659248 CNV deletion 23128226
esv2745622 CNV deletion 23290073
esv3548860 CNV deletion 23714750
esv3580174 CNV loss 25503493
esv3580175 CNV loss 25503493
esv3591 CNV loss 18987735
esv3628788 CNV gain 21293372
esv3628789 CNV loss 21293372
esv7360 CNV loss 19470904
esv990517 CNV deletion 20482838
nsv1039951 CNV loss 25217958
nsv1051454 CNV loss 25217958
nsv1054997 CNV gain 25217958
nsv1070515 CNV deletion 25765185
nsv1159988 CNV duplication 26073780
nsv523367 CNV loss 19592680
nsv557704 CNV gain 21841781
nsv635 CNV insertion 18451855
nsv826279 CNV loss 20364138

Variation tolerance for SLCO1C1 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.61; 97.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO1C1 Gene

Human Gene Mutation Database (HGMD)
SLCO1C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO1C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1C1 Gene

Disorders for SLCO1C1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLCO1C1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
allan-herndon-dudley syndrome
  • ahds
hyperthyroidism
  • overactive thyroid
fanconi-like syndrome
  • fanconi like syndrome
chronic cholangitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO1C1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLCO1C1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO1C1 Gene

Publications for SLCO1C1 Gene

  1. Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. (PMID: 18687783) Roberts LM … Zerangue N (Endocrinology 2008) 3 4 23
  2. Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation. (PMID: 18566113) van der Deure WM … Visser TJ (Endocrinology 2008) 3 23 41
  3. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. (PMID: 12351693) Pizzagalli F … Meier PJ (Molecular endocrinology (Baltimore, Md.) 2002) 3 4 26
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 41
  5. Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. (PMID: 18845642) Westholm DE … Anderson GW (Endocrinology 2009) 3 26

ExternalLinks

View latest publications for SLCO1C1 gene in Mastermind

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Sources for SLCO1C1 Gene