Aliases for SLCO1B7 Gene

Aliases for SLCO1B7 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1B7 (Putative) 2 3 5
  • LST3 2 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 1B7 (Non-Functional) 2 3
  • Putative Solute Carrier Organic Anion Transporter Family Member 1B7 3 4
  • Liver-Specific Organic Anion Transporter 3 3 4
  • SLC21A21 2 3
  • LST-3 3 4
  • Solute Carrier Organic Anion Transporter Family Member 1B7 (Non-Functional) 2
  • Liver-Specific Organic Anion Transporter 3TM12 3
  • Organic Anion Transporter LST-3b 3
  • LST-3TM12 3
  • LST3TM12 4
  • SLCO1B7 5

External Ids for SLCO1B7 Gene

Previous GeneCards Identifiers for SLCO1B7 Gene

  • GC12P021169
  • GC12P020969
  • GC12P020970
  • GC12P020975
  • GC12P020980
  • GC12P020985

Summaries for SLCO1B7 Gene

GeneCards Summary for SLCO1B7 Gene

SLCO1B7 (Solute Carrier Organic Anion Transporter Family Member 1B7 (Putative)) is a Protein Coding gene. Among its related pathways are Bile secretion. Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity.

Additional gene information for SLCO1B7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLCO1B7 Gene

Genomics for SLCO1B7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLCO1B7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J020822 Promoter/Enhancer 1 EPDnew FANTOM5 ENCODE 0.1 -140.3 -140295 0.4 SIN3A POLR2A SLCO1B3 piR-36770-023 SLCO1B3-SLCO1B7 NONHSAG010647.2 ENSG00000256157 SLCO1B7
GH12J020901 Promoter 0.3 EPDnew 0.2 -61.4 -61407 0.1 SLCO1B3 lnc-SLCO1A2-5 piR-38005-006 SLCO1B7 SLCO1B3-SLCO1B7
GH12J021073 Enhancer 0.5 Ensembl ENCODE 0.1 +111.2 111177 1.8 CTCF JUND SLCO1B3 piR-47211-118 ENSG00000257062 SLCO1B1 SLCO1B7 SLCO1B3-SLCO1B7
GH12J020875 Promoter 0.3 EPDnew 0.2 -87.4 -87355 0.1 SLCO1B3 piR-38005-006 SLCO1B3-SLCO1B7 lnc-SLCO1A2-5 NONHSAG010647.2 SLCO1B7
GH12J021009 Enhancer 0.2 FANTOM5 0.3 +46.7 46714 0 piR-31534-123 SLCO1B3 SLCO1B1 piR-31534-124 ENSG00000257062 SLCO1B7 SLCO1B3-SLCO1B7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLCO1B7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLCO1B7

Genomic Locations for SLCO1B7 Gene

Genomic Locations for SLCO1B7 Gene
chr12:20,962,768-21,092,745
(GRCh38/hg38)
Size:
129,978 bases
Orientation:
Plus strand
chr12:20,968,673-21,245,679
(GRCh37/hg19)
Size:
277,007 bases
Orientation:
Plus strand

Genomic View for SLCO1B7 Gene

Genes around SLCO1B7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1B7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1B7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1B7 Gene

Proteins for SLCO1B7 Gene

  • Protein details for SLCO1B7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    G3V0H7-SO1B7_HUMAN
    Recommended name:
    Putative solute carrier organic anion transporter family member 1B7
    Protein Accession:
    G3V0H7
    Secondary Accessions:
    • Q71QF0

    Protein attributes for SLCO1B7 Gene

    Size:
    640 amino acids
    Molecular mass:
    71247 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLCO1B7 Gene

Post-translational modifications for SLCO1B7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLCO1B7 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for SLCO1B7 Gene

Domains & Families for SLCO1B7 Gene

Gene Families for SLCO1B7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLCO1B7 Gene

Graphical View of Domain Structure for InterPro Entry

G3V0H7

UniProtKB/Swiss-Prot:

SO1B7_HUMAN :
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1B7: view

No data available for Suggested Antigen Peptide Sequences for SLCO1B7 Gene

Function for SLCO1B7 Gene

Phenotypes From GWAS Catalog for SLCO1B7 Gene

Gene Ontology (GO) - Molecular Function for SLCO1B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015125 bile acid transmembrane transporter activity IBA 21873635
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLCO1B7: view
genes like me logo Genes that share phenotypes with SLCO1B7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO1B7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1B7 Gene

Localization for SLCO1B7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1B7 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO1B7 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLCO1B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with SLCO1B7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO1B7 Gene

Pathways & Interactions for SLCO1B7 Gene

PathCards logo

SuperPathways for SLCO1B7 Gene

SuperPathway Contained pathways
1 Bile secretion
genes like me logo Genes that share pathways with SLCO1B7: view

Pathways by source for SLCO1B7 Gene

1 KEGG pathway for SLCO1B7 Gene

Interacting Proteins for SLCO1B7 Gene

Gene Ontology (GO) - Biological Process for SLCO1B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015721 bile acid and bile salt transport IBA 21873635
GO:0043252 sodium-independent organic anion transport IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO1B7: view

No data available for SIGNOR curated interactions for SLCO1B7 Gene

Drugs & Compounds for SLCO1B7 Gene

No Compound Related Data Available

Transcripts for SLCO1B7 Gene

mRNA/cDNA for SLCO1B7 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLCO1B7

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B7 Gene

No ASD Table

Relevant External Links for SLCO1B7 Gene

GeneLoc Exon Structure for
SLCO1B7

Expression for SLCO1B7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO1B7 Gene

mRNA differential expression in normal tissues according to GTEx for SLCO1B7 Gene

This gene is overexpressed in Liver (x38.7) and Testis (x8.4).

Protein differential expression in normal tissues from HIPED for SLCO1B7 Gene

This gene is overexpressed in Liver (41.0) and Gallbladder (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO1B7 Gene



Protein tissue co-expression partners for SLCO1B7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLCO1B7

SOURCE GeneReport for Unigene cluster for SLCO1B7 Gene:

Hs.729117
genes like me logo Genes that share expression patterns with SLCO1B7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO1B7 Gene

Orthologs for SLCO1B7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLCO1B7 30
  • 99.11 (n)
-- 31
  • 91 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia OATPC 31
  • 62 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 60 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Slco1b2 31
  • 56 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 35 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 33 (a)
OneToMany
Species where no ortholog for SLCO1B7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLCO1B7 Gene

ENSEMBL:
Gene Tree for SLCO1B7 (if available)
TreeFam:
Gene Tree for SLCO1B7 (if available)

Paralogs for SLCO1B7 Gene

(13) SIMAP similar genes for SLCO1B7 Gene using alignment to 3 proteins:

  • SO1B7_HUMAN
  • F5H094_HUMAN
  • H0YFQ8_HUMAN
genes like me logo Genes that share paralogs with SLCO1B7: view

No data available for Paralogs for SLCO1B7 Gene

Variants for SLCO1B7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLCO1B7 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
770226 Benign: not provided 21,076,479(+) G/A MISSENSE_VARIANT
776697 Benign: not provided 21,043,477(+) A/G MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SLCO1B7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLCO1B7 Gene

Variant ID Type Subtype PubMed ID
dgv1403n100 CNV loss 25217958
dgv1404n100 CNV loss 25217958
dgv2401n54 CNV loss 21841781
esv3548864 CNV deletion 23714750
esv3580181 CNV loss 25503493
esv3628799 CNV loss 21293372
esv3628801 CNV loss 21293372
nsv1035807 CNV loss 25217958
nsv1043893 CNV loss 25217958
nsv1054997 CNV gain 25217958
nsv1144612 CNV deletion 24896259
nsv1144613 CNV deletion 24896259
nsv1159989 CNV duplication 26073780
nsv469159 CNV loss 19166990
nsv515735 CNV gain+loss 19592680
nsv557718 CNV loss 21841781

Variation tolerance for SLCO1B7 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO1B7 Gene

Human Gene Mutation Database (HGMD)
SLCO1B7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO1B7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1B7 Gene

Disorders for SLCO1B7 Gene

No disorders were found for SLCO1B7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLCO1B7 Gene

Publications for SLCO1B7 Gene

  1. OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. (PMID: 31127008) Malagnino V … Meyer Zu Schwabedissen HE (Molecular pharmacology 2019) 3
  2. LST-3TM12 is a member of the OATP1B family and a functional transporter. (PMID: 29248594) Malagnino V … Meyer Zu Schwabedissen HE (Biochemical pharmacology 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. (PMID: 20837016) Buch S … Hampe J (Gastroenterology 2010) 3
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4

Products for SLCO1B7 Gene

Sources for SLCO1B7 Gene