SLCO1B3-SLCO1B7 Gene (Protein Coding)

SLCO1B3-SLCO1B7 Readthrough

GC12P020816
GIFtS:
9
This locus represents naturally occurring readthrough transcription between the neighboring SLCO1B3 (solute carrier organic anion transporter family member 1B3) and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) genes on chromosome 12. The readthrough transcript encodes a protein that shares sequence identity with both the upstream and downstrea... See more...

Aliases for SLCO1B3-SLCO1B7 Gene

Aliases for SLCO1B3-SLCO1B7 Gene

  • SLCO1B3-SLCO1B7 Readthrough 2 3 5
  • SLCO1B3-SLCO1B7 3 5
  • OATP1B3-1B7 2 3
  • LST-3TM12 2 3
  • Solute Carrier Organic Anion Transporter Family Member 13

External Ids for SLCO1B3-SLCO1B7 Gene

Previous GeneCards Identifiers for SLCO1B3-SLCO1B7 Gene

  • GC12U902885

Summaries for SLCO1B3-SLCO1B7 Gene

Entrez Gene Summary for SLCO1B3-SLCO1B7 Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring SLCO1B3 (solute carrier organic anion transporter family member 1B3) and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) genes on chromosome 12. The readthrough transcript encodes a protein that shares sequence identity with both the upstream and downstream genes. [provided by RefSeq, Jun 2019]

GeneCards Summary for SLCO1B3-SLCO1B7 Gene

SLCO1B3-SLCO1B7 (SLCO1B3-SLCO1B7 Readthrough) is a Protein Coding gene. An important paralog of this gene is SLCO1B3.

Additional gene information for SLCO1B3-SLCO1B7 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLCO1B3-SLCO1B7 Gene

Genomics for SLCO1B3-SLCO1B7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SLCO1B3-SLCO1B7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J020822 Promoter/Enhancer 1 EPDnew FANTOM5 ENCODE 0.4 +6.8 6799 0.4 SIN3A POLR2A SLCO1B3 piR-36770-023 SLCO1B3-SLCO1B7 NONHSAG010647.2 ENSG00000256157 SLCO1B7
GH12J020875 Promoter 0.3 EPDnew 0.2 +59.7 59739 0.1 SLCO1B3 piR-38005-006 SLCO1B3-SLCO1B7 lnc-SLCO1A2-5 NONHSAG010647.2 SLCO1B7
GH12J020901 Promoter 0.3 EPDnew 0.2 +85.7 85687 0.1 SLCO1B3 lnc-SLCO1A2-5 piR-38005-006 SLCO1B7 SLCO1B3-SLCO1B7
GH12J020854 Enhancer 0.2 Ensembl 0.3 +39.0 39027 0.6 SLCO1B3 ENSG00000256157 piR-38005-006 SLCO1B3-SLCO1B7 NONHSAG010647.2 SLCO1B7
GH12J020906 Enhancer 0.2 FANTOM5 0.2 +90.8 90786 0.3 SLCO1B1 SLCO1B3 SLCO1A2 lnc-SLCO1A2-5 piR-38005-006 SLCO1B7 SLCO1B3-SLCO1B7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLCO1B3-SLCO1B7 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for SLCO1B3-SLCO1B7 Gene

Genomic Locations for SLCO1B3-SLCO1B7 Gene
chr12:20,815,674-21,091,222
(GRCh38/hg38)
Size:
275,549 bases
Orientation:
Plus strand
chr12:20,968,608-21,243,179
(GRCh37/hg19)
Size:
274,572 bases
Orientation:
Plus strand

Genomic View for SLCO1B3-SLCO1B7 Gene

Genes around SLCO1B3-SLCO1B7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1B3-SLCO1B7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1B3-SLCO1B7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLCO1B3-SLCO1B7 Gene

Proteins for SLCO1B3-SLCO1B7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SLCO1B3-SLCO1B7 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F5H094-F5H094_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member
    Protein Accession:
    F5H094

    Protein attributes for SLCO1B3-SLCO1B7 Gene

    Size:
    687 amino acids
    Molecular mass:
    76346 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLCO1B3-SLCO1B7 Gene

Post-translational modifications for SLCO1B3-SLCO1B7 Gene

No Post-translational modifications

Other Protein References for SLCO1B3-SLCO1B7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO1B3-SLCO1B7 Gene

Domains & Families for SLCO1B3-SLCO1B7 Gene

Gene Families for SLCO1B3-SLCO1B7 Gene

Unknown:
  • Belongs to the organo anion transporter (TC 2.A.60) family.

Protein Domains for SLCO1B3-SLCO1B7 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SLCO1B3-SLCO1B7: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SLCO1B3-SLCO1B7 Gene

Function for SLCO1B3-SLCO1B7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for SLCO1B3-SLCO1B7 Gene

Gene Ontology (GO) - Molecular Function for SLCO1B3-SLCO1B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0015125 bile acid transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO1B3-SLCO1B7: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1B3-SLCO1B7 Gene

Localization for SLCO1B3-SLCO1B7 Gene

Gene Ontology (GO) - Cellular Components for SLCO1B3-SLCO1B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO1B3-SLCO1B7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SLCO1B3-SLCO1B7 Gene

Pathways & Interactions for SLCO1B3-SLCO1B7 Gene

PathCards logo

SuperPathways for SLCO1B3-SLCO1B7 Gene

No Data Available

Interacting Proteins for SLCO1B3-SLCO1B7 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000441269 for SLCO1B3-SLCO1B7 Gene via STRING

Symbol External ID(s) Details
LIPC
GPS-Prot Interaction Network for SLCO1B3-SLCO1B7

Gene Ontology (GO) - Biological Process for SLCO1B3-SLCO1B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015721 bile acid and bile salt transport IBA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLCO1B3-SLCO1B7: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO1B3-SLCO1B7 Gene

Drugs & Compounds for SLCO1B3-SLCO1B7 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SLCO1B3-SLCO1B7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SLCO1B3-SLCO1B7 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B3-SLCO1B7 Gene

No ASD Table

Relevant External Links for SLCO1B3-SLCO1B7 Gene

GeneLoc Exon Structure for
SLCO1B3-SLCO1B7

Expression for SLCO1B3-SLCO1B7 Gene

Products:

  1. Primer
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO1B3-SLCO1B7 Gene

Orthologs for SLCO1B3-SLCO1B7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B3-SLCO1B7 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
 Mammalia OATPC 31
  • 70 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia -- 31
  • 69 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Slco1b2 31
  • 65 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 61 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 49 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 31
  • 38 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 36 (a)
 OneToMany
Species where no ortholog for SLCO1B3-SLCO1B7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLCO1B3-SLCO1B7 Gene

ENSEMBL:
Gene Tree for SLCO1B3-SLCO1B7 (if available)
TreeFam:
Gene Tree for SLCO1B3-SLCO1B7 (if available)

Paralogs for SLCO1B3-SLCO1B7 Gene

Paralogs for SLCO1B3-SLCO1B7 Gene

genes like me logo Genes that share paralogs with SLCO1B3-SLCO1B7: view

Variants for SLCO1B3-SLCO1B7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLCO1B3-SLCO1B7 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
712105 Conflicting Interpretations: Rotor syndrome; not provided 20,855,146(+) T/TAATTG FRAMESHIFT_VARIANT
719501 Benign: Rotor syndrome; not provided 20,815,807(+) C/T SYNONYMOUS_VARIANT
722875 Conflicting Interpretations: Rotor syndrome; not specified; not provided 20,883,599(+) T/C MISSENSE_VARIANT
724243 Conflicting Interpretations: Rotor syndrome; not provided 20,877,875(+) C/T SYNONYMOUS_VARIANT
727114 Conflicting Interpretations: Rotor syndrome; not provided 20,877,902(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SLCO1B3-SLCO1B7 Gene

Additional Variant Information for SLCO1B3-SLCO1B7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO1B3-SLCO1B7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SLCO1B3-SLCO1B7 Gene

Disorders for SLCO1B3-SLCO1B7 Gene

Additional Disease Information for SLCO1B3-SLCO1B7

Open Targets Platform

No disorders were found for SLCO1B3-SLCO1B7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLCO1B3-SLCO1B7 Gene

Publications for SLCO1B3-SLCO1B7 Gene

  1. OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. (PMID: 31127008) Malagnino V … Meyer Zu Schwabedissen HE (Molecular pharmacology 2019) 2 3
  2. LST-3TM12 is a member of the OATP1B family and a functional transporter. (PMID: 29248594) Malagnino V … Meyer Zu Schwabedissen HE (Biochemical pharmacology 2018) 2 3
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 13

No data available for Mastermind for SLCO1B3-SLCO1B7 Gene

Products for SLCO1B3-SLCO1B7 Gene

Sources for SLCO1B3-SLCO1B7 Gene