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Aliases for SLCO1B3 Gene

Aliases for SLCO1B3 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1B3 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 8 2 3
  • Liver-Specific Organic Anion Transporter 2 3 4
  • Organic Anion-Transporting Polypeptide 8 3 4
  • Organic Anion Transporter 8 3 4
  • SLC21A8 3 4
  • OATP1B3 3 4
  • OATP-8 3 4
  • LST-2 3 4
  • OATP8 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 1B3 2
  • Liver-Specific Organic Anion Transporter 3TM13 3
  • Solute Carrier Family 21 Member 8 4
  • Organic Anion Transporter LST-3c 3
  • LST-3TM13 3
  • HBLRR 3
  • LST3 3
  • LST2 4

External Ids for SLCO1B3 Gene

Previous HGNC Symbols for SLCO1B3 Gene

  • SLC21A8

Previous GeneCards Identifiers for SLCO1B3 Gene

  • GC12P020859
  • GC12P020963

Summaries for SLCO1B3 Gene

Entrez Gene Summary for SLCO1B3 Gene

  • This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017]

GeneCards Summary for SLCO1B3 Gene

SLCO1B3 (Solute Carrier Organic Anion Transporter Family Member 1B3) is a Protein Coding gene. Diseases associated with SLCO1B3 include Hyperbilirubinemia, Rotor Type and Intrahepatic Cholestasis. Among its related pathways are Gefitinib Pathway, Pharmacokinetics and Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is ENSG00000257046.

UniProtKB/Swiss-Prot for SLCO1B3 Gene

  • Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Gene Wiki entry for SLCO1B3 Gene

Additional gene information for SLCO1B3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1B3 Gene

Genomics for SLCO1B3 Gene

GeneHancer (GH) Regulatory Elements for SLCO1B3 Gene

Promoters and enhancers for SLCO1B3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I020810 Promoter 0.6 EPDnew 550.8 0.0 -16 0.1 TAF1 SLCO1B3 GC12M020713
GH12I020822 Enhancer 0.7 FANTOM5 ENCODE 22.3 +11.8 11771 0.4 POLR2A SIN3A GC12M020817 SLCO1B3 PIR33253 ENSG00000257046
GH12I021073 Enhancer 0.3 ENCODE 4.5 +263.2 263243 1.8 JUND SLCO1B3 ENSG00000257062 SLCO1B1 SLCO1B7 ENSG00000257046
GH12I020906 Enhancer 0.2 FANTOM5 3.6 +95.8 95758 0.3 SLCO1B1 SLCO1B7 SLCO1B3 SLCO1A2 GC12M020897 GC12P020879 ENSG00000257046
GH12I021275 Enhancer 0.2 FANTOM5 3.4 +465.3 465346 0.1 PIR55925 GYS2 SLCO1B1 SLCO1A2 SLCO1B3 KCNJ8 GC12P021259
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO1B3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO1B3 gene promoter:

Genomic Locations for SLCO1B3 Gene

Genomic Locations for SLCO1B3 Gene
106,210 bases
Plus strand

Genomic View for SLCO1B3 Gene

Genes around SLCO1B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1B3 Gene

Proteins for SLCO1B3 Gene

  • Protein details for SLCO1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 1B3
    Protein Accession:
    Secondary Accessions:
    • E7EMT8
    • Q5JAR4

    Protein attributes for SLCO1B3 Gene

    702 amino acids
    Molecular mass:
    77403 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1B3 Gene


neXtProt entry for SLCO1B3 Gene

Post-translational modifications for SLCO1B3 Gene

  • N-glycosylated.
  • Glycosylation at posLast=134134, isoforms=2145, posLast=151151, posLast=445445, posLast=503503, and isoforms=2516
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO1B3 Gene

No data available for DME Specific Peptides for SLCO1B3 Gene

Domains & Families for SLCO1B3 Gene

Gene Families for SLCO1B3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1B3: view

Function for SLCO1B3 Gene

Molecular function for SLCO1B3 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Phenotypes From GWAS Catalog for SLCO1B3 Gene

Gene Ontology (GO) - Molecular Function for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity TAS 10779507
GO:0015125 bile acid transmembrane transporter activity TAS --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO1B3: view
genes like me logo Genes that share phenotypes with SLCO1B3: view

Human Phenotype Ontology for SLCO1B3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLCO1B3 Gene

MGI Knock Outs for SLCO1B3:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for SLCO1B3 (OATP1B3/SLCO1B3)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLCO1B3 Gene

Localization for SLCO1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1B3 Gene

Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO1B3 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10779507
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLCO1B3: view

Pathways & Interactions for SLCO1B3 Gene

genes like me logo Genes that share pathways with SLCO1B3: view

Interacting Proteins for SLCO1B3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9NPD5-SO1B3_HUMAN ENSP00000261196 for SLCO1B3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015711 organic anion transport TAS 10779507
GO:0015721 bile acid and bile salt transport TAS --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO1B3: view

No data available for SIGNOR curated interactions for SLCO1B3 Gene

Drugs & Compounds for SLCO1B3 Gene

(82) Drugs for SLCO1B3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifampin Approved Pharma Agonist, Target, Transporter, substrate, inhibitor, binder 376
Docetaxel Approved May 1996, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2040
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Dabrafenib Approved, Investigational Pharma Transporter, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 92
Mycophenolate mofetil Approved, Investigational Pharma Transporter, substrate IMPDH inhibitor 987

(87) Additional Compounds for SLCO1B3 Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate

(1) ApexBio Compounds for SLCO1B3 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO1B3: view

Drug Products

Transcripts for SLCO1B3 Gene

Unigene Clusters for SLCO1B3 Gene

Solute carrier organic anion transporter family, member 1B3:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for SLCO1B3 (OATP1B3/SLCO1B3)

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B3 Gene

No ASD Table

Relevant External Links for SLCO1B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO1B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO1B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1B3 Gene

This gene is overexpressed in Liver (x47.0).

Protein differential expression in normal tissues from HIPED for SLCO1B3 Gene

This gene is overexpressed in Gallbladder (33.5) and Liver (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO1B3 Gene

Protein tissue co-expression partners for SLCO1B3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLCO1B3 Gene:


SOURCE GeneReport for Unigene cluster for SLCO1B3 Gene:


mRNA Expression by UniProt/SwissProt for SLCO1B3 Gene:

Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

Evidence on tissue expression from TISSUES for SLCO1B3 Gene

  • Liver(4.8)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO1B3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • integumentary
  • nervous
  • skeleton
Head and neck:
  • eye
  • head
  • mouth
  • biliary tract
  • liver
  • skin
genes like me logo Genes that share expression patterns with SLCO1B3: view

Orthologs for SLCO1B3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLCO1B3 33
  • 81.88 (n)
  • 71 (a)
(Bos Taurus)
Mammalia SLCO1B3 33
  • 80.9 (n)
-- 34
  • 70 (a)
(Mus musculus)
Mammalia Slco1b2 33 16 34
  • 75.88 (n)
(Rattus norvegicus)
Mammalia Slco1b2 33
  • 75.46 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
(Gallus gallus)
Aves -- 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
Species where no ortholog for SLCO1B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1B3 Gene

Gene Tree for SLCO1B3 (if available)
Gene Tree for SLCO1B3 (if available)

Paralogs for SLCO1B3 Gene

genes like me logo Genes that share paralogs with SLCO1B3: view

Variants for SLCO1B3 Gene

Sequence variations from dbSNP and Humsavar for SLCO1B3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs115227445 uncertain-significance, Rotor syndrome 20,862,803(+) C/G/T coding_sequence_variant, missense_variant, synonymous_variant
rs117703648 likely-benign, Rotor syndrome 20,916,795(+) A/T 3_prime_UTR_variant
rs142694767 uncertain-significance, Rotor syndrome 20,883,513(+) A/G coding_sequence_variant, synonymous_variant
rs143827641 uncertain-significance, Rotor syndrome 20,901,459(+) A/T coding_sequence_variant, synonymous_variant
rs145334570 uncertain-significance, Rotor syndrome 20,858,547(+) C/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO1B3 Gene

Variant ID Type Subtype PubMed ID
dgv1403n100 CNV loss 25217958
dgv2399n54 CNV loss 21841781
dgv2400n54 CNV loss 21841781
dgv2401n54 CNV loss 21841781
dgv2402n54 CNV loss 21841781
dgv2403n54 CNV loss 21841781
dgv259e214 CNV loss 21293372
dgv276n67 CNV gain 20364138
dgv465e212 CNV loss 25503493
dgv466e212 CNV loss 25503493
dgv4e24 CNV loss 17666407
esv24973 CNV gain 19812545
esv2663290 CNV deletion 23128226
esv2666827 CNV deletion 23128226
esv2672824 CNV deletion 23128226
esv2750761 CNV loss 17666407
esv2759882 CNV gain+loss 17122850
esv3306807 CNV mobile element insertion 20981092
esv3323113 CNV insertion 20981092
esv3429101 CNV insertion 20981092
esv3580176 CNV loss 25503493
esv3628793 CNV loss 21293372
esv3628795 CNV loss 21293372
esv3628797 CNV loss 21293372
esv3628798 CNV loss 21293372
esv3628799 CNV loss 21293372
nsv1041345 CNV loss 25217958
nsv1051454 CNV loss 25217958
nsv1054997 CNV gain 25217958
nsv1075845 CNV duplication 25765185
nsv1113466 CNV deletion 24896259
nsv1113467 CNV deletion 24896259
nsv1132356 CNV duplication 24896259
nsv1134207 CNV deletion 24896259
nsv1138113 CNV deletion 24896259
nsv1142136 CNV tandem duplication 24896259
nsv1144611 CNV deletion 24896259
nsv1146315 CNV duplication 26484159
nsv1148189 CNV insertion 26484159
nsv1159989 CNV duplication 26073780
nsv428275 CNV gain 18775914
nsv438195 CNV loss 16468122
nsv509459 CNV insertion 20534489
nsv515735 CNV gain+loss 19592680
nsv557709 CNV loss 21841781
nsv636 CNV insertion 18451855
nsv8927 CNV gain 18304495
nsv8928 CNV loss 18304495

Variation tolerance for SLCO1B3 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO1B3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1B3 Gene

Disorders for SLCO1B3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLCO1B3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hyperbilirubinemia, rotor type
  • hblrr
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards


  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269 PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLCO1B3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO1B3: view

No data available for Genatlas for SLCO1B3 Gene

Publications for SLCO1B3 Gene

  1. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PMID: 11375950) Abe T … Matsuno S (Gastroenterology 2001) 3 4 22 25 58
  2. Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. (PMID: 18509328) Franke RM … Sparreboom A (Clinical pharmacology and therapeutics 2008) 3 22 44 58
  3. Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure. (PMID: 19122334) Tsujimoto M … Sawada Y (Drug metabolism and pharmacokinetics 2008) 3 22 44 58
  4. Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics. (PMID: 17186002) Smith NF … Sparreboom A (Clinical pharmacology and therapeutics 2007) 3 22 44 58
  5. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. (PMID: 22232210) van de Steeg E … Schinkel AH (The Journal of clinical investigation 2012) 3 4 58

Products for SLCO1B3 Gene

Sources for SLCO1B3 Gene

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