Aliases for SLCO1A2 Gene
External Ids for SLCO1A2 Gene
Previous HGNC Symbols for SLCO1A2 Gene
Previous GeneCards Identifiers for SLCO1A2 Gene
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
GeneCards Summary for SLCO1A2 Gene
SLCO1A2 (Solute Carrier Organic Anion Transporter Family Member 1A2) is a Protein Coding gene. Diseases associated with SLCO1A2 include Intrahepatic Cholestasis Of Pregnancy and Cholelithiasis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. Gene Ontology (GO) annotations related to this gene include transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1C1.
UniProtKB/Swiss-Prot Summary for SLCO1A2 Gene
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.