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Aliases for SLC9C2 Gene

Aliases for SLC9C2 Gene

  • Solute Carrier Family 9 Member C2 (Putative) 2 3 5
  • Solute Carrier Family 9, Member 11 2 3
  • Na(+)/H(+) Exchanger 11 3 4
  • SLC9A11 3 4
  • NHE-11 3 4
  • Solute Carrier Family 9, Isoform 11 2
  • Solute Carrier Family 9, Member C2 2
  • Solute Carrier Family 9 Member 11 4
  • Solute Carrier Family 9 Member C2 4
  • Sodium/Hydrogen Exchanger 11 3
  • Solute Carrier Family 9 3

External Ids for SLC9C2 Gene

Previous HGNC Symbols for SLC9C2 Gene

  • SLC9A11

Summaries for SLC9C2 Gene

GeneCards Summary for SLC9C2 Gene

SLC9C2 (Solute Carrier Family 9 Member C2 (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9C1.

UniProtKB/Swiss-Prot for SLC9C2 Gene

  • Involved in pH regulation.

Gene Wiki entry for SLC9C2 Gene

Additional gene information for SLC9C2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9C2 Gene

Genomics for SLC9C2 Gene

GeneHancer (GH) Regulatory Elements for SLC9C2 Gene

Promoters and enhancers for SLC9C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I173602 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.0 11 1.1 HDAC1 PKNOX1 ATF1 ARNT CHAMP1 FOS ATF7 CEBPB ZNF592 ZNF148 SLC9C2 TEX50 KLHL20 ENSG00000238272
GH01I173506 Enhancer 1.1 Ensembl ENCODE 10 +95.7 95737 1.8 PKNOX1 FOXA2 ZFP64 FEZF1 GLIS2 ZNF143 KLF7 FOS KLF13 SP3 PRDX6 ANKRD45 ENSG00000238272 KLHL20 SLC9C2 GAS5 PIR59510
GH01I173428 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6 +172.7 172652 3.5 PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 REST GC01M173428 PRDX6 SLC9C2 GC01P173448 LOC101928673 LOC100506023
GH01I173526 Enhancer 0.8 ENCODE 10.5 +75.8 75812 1 FOXA2 PKNOX1 SMAD1 NFIB BRCA1 RAD21 YY1 GTF3C2 POLR3A ZNF350 ZBTB37 ENSG00000238272 PRDX6 SLC9C2 KLHL20 GAS5 PIR59510
GH01I173425 Enhancer 1.2 Ensembl ENCODE dbSUPER 6 +180.5 180452 0.3 ATF1 IRF4 ZNF766 ATF7 CREM CAVIN1 ZBTB11 HDAC8 ZNF592 MEF2D SLC9C2 GC01M173428 LOC101928673 LOC100506023 LOC646870
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC9C2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC9C2 Gene

Genomic Locations for SLC9C2 Gene
chr1:173,500,464-173,603,094
(GRCh38/hg38)
Size:
102,631 bases
Orientation:
Minus strand
chr1:173,469,603-173,572,233
(GRCh37/hg19)

Genomic View for SLC9C2 Gene

Genes around SLC9C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9C2 Gene

Proteins for SLC9C2 Gene

  • Protein details for SLC9C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAH2-SL9C2_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 11
    Protein Accession:
    Q5TAH2
    Secondary Accessions:
    • Q86UF3

    Protein attributes for SLC9C2 Gene

    Size:
    1124 amino acids
    Molecular mass:
    129053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC9C2 Gene

Post-translational modifications for SLC9C2 Gene

  • Glycosylation at posLast=447447 and isoforms=473
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC9C2 Gene

Domains & Families for SLC9C2 Gene

Gene Families for SLC9C2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC9C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TAH2

UniProtKB/Swiss-Prot:

SL9C2_HUMAN :
  • Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Domain:
  • Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9C2: view

Function for SLC9C2 Gene

Molecular function for SLC9C2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pH regulation.

Gene Ontology (GO) - Molecular Function for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0015299 solute:proton antiporter activity IEA --
GO:0015385 sodium:proton antiporter activity IBA --
GO:0015386 potassium:proton antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC9C2: view
genes like me logo Genes that share phenotypes with SLC9C2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC9C2 Gene

Localization for SLC9C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9C2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC9C2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC9C2 Gene

Pathways & Interactions for SLC9C2 Gene

genes like me logo Genes that share pathways with SLC9C2: view

Pathways by source for SLC9C2 Gene

Interacting Proteins for SLC9C2 Gene

Gene Ontology (GO) - Biological Process for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0051453 regulation of intracellular pH IBA --
genes like me logo Genes that share ontologies with SLC9C2: view

No data available for SIGNOR curated interactions for SLC9C2 Gene

Drugs & Compounds for SLC9C2 Gene

No Compound Related Data Available

Transcripts for SLC9C2 Gene

Unigene Clusters for SLC9C2 Gene

Solute carrier family 9, member C2 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: -
SP3: - -
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:

Relevant External Links for SLC9C2 Gene

GeneLoc Exon Structure for
SLC9C2
ECgene alternative splicing isoforms for
SLC9C2

Expression for SLC9C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC9C2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9C2 Gene

This gene is overexpressed in Testis (x20.6) and Brain - Caudate (basal ganglia) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SLC9C2 Gene:

SLC9C2

SOURCE GeneReport for Unigene cluster for SLC9C2 Gene:

Hs.494981
genes like me logo Genes that share expression patterns with SLC9C2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC9C2 Gene

Orthologs for SLC9C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC9C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9C2 33 34
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia SLC9C2 33 34
  • 83.54 (n)
dog
(Canis familiaris)
Mammalia SLC9C2 33 34
  • 83.41 (n)
rat
(Rattus norvegicus)
Mammalia Slc9c2 33
  • 76.29 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9C2 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
Species where no ortholog for SLC9C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC9C2 Gene

ENSEMBL:
Gene Tree for SLC9C2 (if available)
TreeFam:
Gene Tree for SLC9C2 (if available)

Paralogs for SLC9C2 Gene

Paralogs for SLC9C2 Gene

(2) SIMAP similar genes for SLC9C2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC9C2: view

Variants for SLC9C2 Gene

Sequence variations from dbSNP and Humsavar for SLC9C2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000061607 -- 173,532,999(-) G/C intron_variant
rs1000090813 -- 173,540,035(-) G/T intron_variant
rs1000120936 -- 173,526,268(-) A/G intron_variant
rs1000124521 -- 173,572,057(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000161307 -- 173,525,851(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9C2 Gene

Variant ID Type Subtype PubMed ID
esv3587945 CNV loss 21293372
esv3587946 CNV loss 21293372
nsv831915 CNV gain+loss 17160897

Variation tolerance for SLC9C2 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC9C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC9C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9C2 Gene

Disorders for SLC9C2 Gene

Additional Disease Information for SLC9C2

No disorders were found for SLC9C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC9C2 Gene

Publications for SLC9C2 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SLC9C2 Gene

Sources for SLC9C2 Gene

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