Aliases for SLC9C2 Gene
Aliases for SLC9C2 Gene
External Ids for SLC9C2 Gene
- HGNC: 28664
- Entrez Gene: 284525
- Ensembl: ENSG00000162753
- UniProtKB: Q5TAH2
Previous HGNC Symbols for SLC9C2 Gene
- SLC9A11
Summaries for SLC9C2 Gene
GeneCards Summary for SLC9C2 Gene
SLC9C2 (Solute Carrier Family 9 Member C2 (Putative)) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9C1.
UniProtKB/Swiss-Prot for SLC9C2 Gene
-
Involved in pH regulation.
Additional gene information for SLC9C2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9C2 Gene
Genomics for SLC9C2 Gene
GeneHancer (GH) Regulatory Elements for SLC9C2 Gene
Promoters and enhancers for SLC9C2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC9C2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SLC9C2 Gene
Genomic Locations for SLC9C2 Gene
- chr1:173,500,464-173,603,094
- (GRCh38/hg38)
- Size:
- 102,631 bases
- Orientation:
- Minus strand
- chr1:173,469,603-173,572,233
- (GRCh37/hg19)
- Size:
- 102,631 bases
- Orientation:
- Minus strand
Genomic View for SLC9C2 Gene
Genes around SLC9C2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.1 by Entrez Gene
- 1q25.1 by HGNC
- 1q25.1 by Ensembl
SLC9C2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC9C2 Gene
Proteins for SLC9C2 Gene
-
Protein details for SLC9C2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5TAH2-SL9C2_HUMAN
- Recommended name:
- Sodium/hydrogen exchanger 11
- Protein Accession:
- Q5TAH2
- Q86UF3
Protein attributes for SLC9C2 Gene
- Size:
- 1124 amino acids
- Molecular mass:
- 129053 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for SLC9C2 Gene
Other Protein References for SLC9C2 Gene
Antibody Products
- Invitrogen Antibodies for SLC9C2 (AFLGC-SLC9C2)
- antibodies-online: Search results for 4 available SLC9C2 Antibodies ranked by validation data
- Compare Top SLC9C2 Antibodies
-
Quality Products:
- Search GeneTex for Antibodies for SLC9C2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC9C2
- Origene Custom Protein Services for SLC9C2
- Search GeneTex for Proteins for SLC9C2
Assay Products
No data available for DME Specific Peptides for SLC9C2 Gene
Domains & Families for SLC9C2 Gene
Gene Families for SLC9C2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC9C2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC9C2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5TAH2UniProtKB/Swiss-Prot:
SL9C2_HUMAN :- Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
- Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
- Domain:
-
- Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
- Family:
-
- Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Function for SLC9C2 Gene
Molecular function for SLC9C2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pH regulation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015297 | antiporter activity | IEA | -- |
| GO:0015299 | solute:proton antiporter activity | IEA | -- |
| GO:0015385 | sodium:proton antiporter activity | IBA | -- |
| GO:0015386 | potassium:proton antiporter activity | IBA | -- |
Phenotypes for SLC9C2 Gene
- GenomeRNAi human phenotypes for SLC9C2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC9C2
-
CRISPR Products
-
OriGene CRISPR knockouts for SLC9C2
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- genomics-online: gRNA clones - Search results for 12 available SLC9C2 gene related products
- Overview of 12 available SLC9C2 gene related products
- Applied Biological Materials CRISPR for SLC9C2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC9C2
- GenScript: Design CRISPR guide RNA sequences for SLC9C2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC9C2
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- genomics-online: shRNA clones - Search results for 12 available SLC9C2 gene related products
- Overview of 12 available SLC9C2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SLC9C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC9C2
- Applied Biological Materials Clones for SLC9C2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SLC9C2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC9C2 Gene
Localization for SLC9C2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC9C2 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC9C2 Gene
Pathways & Interactions for SLC9C2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ion channel transport | ||
| 2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
Pathways by source for SLC9C2 Gene
3 Reactome pathways for SLC9C2 Gene
Interacting Proteins for SLC9C2 Gene
GPS-Prot Interaction Network for SLC9C2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006812 | cation transport | IEA | -- |
| GO:0006814 | sodium ion transport | IEA | -- |
| GO:0051453 | regulation of intracellular pH | IBA | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC9C2 Gene
Transcripts for SLC9C2 Gene
mRNA/cDNA for SLC9C2 Gene
- (13) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (18) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000367714 4428 bps (uc001giz.3)
- ENST00000466087 3333 bps (uc057njd.1)
- ENST00000479367 760 bps (uc057njf.1)
- ENST00000476568 230 bps (uc057njg.1)
Unigene Clusters for SLC9C2 Gene
- Solute carrier family 9, member C2 (putative):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SLC9C2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC9C2
- genomics-online: gRNA clones - Search results for 12 available SLC9C2 gene related products
- Overview of 12 available SLC9C2 gene related products
- Applied Biological Materials CRISPR for SLC9C2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC9C2
- GenScript: Design CRISPR guide RNA sequences for SLC9C2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC9C2
- Browse OriGene Inhibitory RNA Products For SLC9C2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC9C2
- genomics-online: shRNA clones - Search results for 12 available SLC9C2 gene related products
- Overview of 12 available SLC9C2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SLC9C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC9C2
- Applied Biological Materials Clones for SLC9C2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: |
Expression for SLC9C2 Gene
mRNA differential expression in normal tissues according to GTEx for SLC9C2 Gene
This gene is overexpressed in Testis (x20.6) and Brain - Caudate (basal ganglia) (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of SLC9C2 Gene:
SLC9C2SOURCE GeneReport for Unigene cluster for SLC9C2 Gene:
Hs.494981Primer Products
-
OriGene qPCR primer pairs for SLC9C2
- genomics-online: primer clones - Search results for 12 available SLC9C2 gene related products
- Overview of 12 available SLC9C2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC9C2 Gene
Orthologs for SLC9C2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC9C2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SLC9C2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SLC9C2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Slc9c2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC9C2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for SLC9C2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for SLC9C2 Gene
- ENSEMBL:
- Gene Tree for SLC9C2 (if available)
- TreeFam:
- Gene Tree for SLC9C2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC9C2: view image
Paralogs for SLC9C2 Gene
Variants for SLC9C2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000061607 | -- | 173,532,999(-) | G/C | intron_variant | |
| rs1000090813 | -- | 173,540,035(-) | G/T | intron_variant | |
| rs1000120936 | -- | 173,526,268(-) | A/G | intron_variant | |
| rs1000124521 | -- | 173,572,057(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000161307 | -- | 173,525,851(-) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3587945 | CNV | loss | 21293372 |
| esv3587946 | CNV | loss | 21293372 |
| nsv831915 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.96;
87.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC9C2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC9C2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9C2 Gene
Disorders for SLC9C2 Gene
Additional Disease Information for SLC9C2
No disorders were found for SLC9C2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC9C2 Gene
Publications for SLC9C2 Gene
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
Products for SLC9C2 Gene
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Sources for SLC9C2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt