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Aliases for SLC9B1 Gene

Aliases for SLC9B1 Gene

  • Solute Carrier Family 9 Member B1 2 3 5
  • Solute Carrier Family 9, Subfamily B (NHA1, Cation Proton Antiporter 1), Member 1 2 3
  • Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 1 2 3
  • Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 1 3 4
  • Na(+)/H(+) Exchanger-Like Domain-Containing Protein 1 3 4
  • NHE Domain-Containing Protein 1 3 4
  • NHEDC1 3 4
  • NHA1 3 4
  • Solute Carrier Family 9, Subfamily B Member 1 4
  • Na+/H+ Exchanger Domain Containing 1 2
  • Testicular Tissue Protein Li 127 3
  • Sodium/Hydrogen Exchanger 9B1 3

External Ids for SLC9B1 Gene

Previous HGNC Symbols for SLC9B1 Gene

  • NHEDC1

Previous GeneCards Identifiers for SLC9B1 Gene

  • GC04M103808

Summaries for SLC9B1 Gene

Entrez Gene Summary for SLC9B1 Gene

  • The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SLC9B1 Gene

SLC9B1 (Solute Carrier Family 9 Member B1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9B2.

UniProtKB/Swiss-Prot for SLC9B1 Gene

  • Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.

Additional gene information for SLC9B1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9B1 Gene

Genomics for SLC9B1 Gene

GeneHancer (GH) Regulatory Elements for SLC9B1 Gene

Promoters and enhancers for SLC9B1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I103018 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 288 2.6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SLC9B1 CISD2 MANBA UBE2D3 NFKB1 ACTR3BP4 SLC9B2
GH04I102998 Promoter 0.5 EPDnew 550.3 +21.3 21270 0.1 SLC9B1 UBE2D3 CISD2 MANBA ACTR3BP4
GH04I102823 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.9 +193.1 193064 7.1 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 UBE2D3 LOC105377348 NFKB1 LOC100419096 MANBA CISD2 SLC9B1 BDH2 LRRC37A15P LOC102723704
GH04I102343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 +675.0 674994 3.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 SLC39A8 SLC9B1 UBE2D3 NFKB1 RN7SL728P GC04M102262
GH04I102627 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 12.8 +391.7 391712 1.6 MEIS2 PKNOX1 TEAD4 JUN BATF IRF4 FOSL1 ZNF335 POLR2A CBFA2T2 NFKB1 SLC9B1 SLC39A8 UBE2D3 MANBA LOC105377347 RPL21P49
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC9B1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC9B1 Gene

Genomic Locations for SLC9B1 Gene
134,692 bases
Minus strand

Genomic View for SLC9B1 Gene

Genes around SLC9B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9B1 Gene

Proteins for SLC9B1 Gene

  • Protein details for SLC9B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/hydrogen exchanger 9B1
    Protein Accession:
    Secondary Accessions:
    • A1KXV1
    • B9EH04
    • C9JBP7
    • Q49A30
    • Q8NCV2
    • Q8WVZ0

    Protein attributes for SLC9B1 Gene

    515 amino acids
    Molecular mass:
    56054 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM22868.1; Type=Frameshift; Positions=219, 298, 381; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC9B1 Gene


neXtProt entry for SLC9B1 Gene

Post-translational modifications for SLC9B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC9B1 Gene

Domains & Families for SLC9B1 Gene

Gene Families for SLC9B1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC9B1 Gene

Suggested Antigen Peptide Sequences for SLC9B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9B1: view

Function for SLC9B1 Gene

Molecular function for SLC9B1 Gene

UniProtKB/Swiss-Prot Function:
Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.

Phenotypes From GWAS Catalog for SLC9B1 Gene

Gene Ontology (GO) - Molecular Function for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0015299 solute:proton antiporter activity IEA --
GO:0015385 sodium:proton antiporter activity TAS --
genes like me logo Genes that share ontologies with SLC9B1: view

Phenotypes for SLC9B1 Gene

GenomeRNAi human phenotypes for SLC9B1:
genes like me logo Genes that share phenotypes with SLC9B1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC9B1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC9B1 Gene

Localization for SLC9B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9B1 Gene

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC9B1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
peroxisome 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042995 cell projection IEA --
GO:0097228 sperm principal piece ISS --
genes like me logo Genes that share ontologies with SLC9B1: view

Pathways & Interactions for SLC9B1 Gene

genes like me logo Genes that share pathways with SLC9B1: view

Pathways by source for SLC9B1 Gene

Gene Ontology (GO) - Biological Process for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with SLC9B1: view

No data available for SIGNOR curated interactions for SLC9B1 Gene

Drugs & Compounds for SLC9B1 Gene

No Compound Related Data Available

Transcripts for SLC9B1 Gene

Unigene Clusters for SLC9B1 Gene

Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B1 Gene

No ASD Table

Relevant External Links for SLC9B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC9B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC9B1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9B1 Gene

This gene is overexpressed in Testis (x28.1).

Protein differential expression in normal tissues from HIPED for SLC9B1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC9B1 Gene

Protein tissue co-expression partners for SLC9B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC9B1 Gene:


SOURCE GeneReport for Unigene cluster for SLC9B1 Gene:


mRNA Expression by UniProt/SwissProt for SLC9B1 Gene:

Tissue specificity: Expressed only in the testis.

Evidence on tissue expression from TISSUES for SLC9B1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC9B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC9B1 Gene

Orthologs for SLC9B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHEDC1 33
  • 99.35 (n)
SLC9B1 34
  • 99 (a)
(Canis familiaris)
Mammalia SLC9B1 33
  • 82.65 (n)
-- 34
  • 71 (a)
(Rattus norvegicus)
Mammalia Slc9b1 33
  • 75.3 (n)
(Mus musculus)
Mammalia Slc9b1 33 16 34
  • 74.37 (n)
(Bos Taurus)
Mammalia NHEDC1 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
(Gallus gallus)
Aves -- 34
  • 50 (a)
(Danio rerio)
Actinopterygii si:dkey-162b23.4 34
  • 42 (a)
CU695013.3 34
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nha1 34
  • 23 (a)
Nha2 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea CELE_F57G8.5 33
  • 44.8 (n)
F57G8.5 34
  • 25 (a)
F41E7.1 34
  • 24 (a)
F41E7.2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6614 34
  • 43 (a)
Species where no ortholog for SLC9B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC9B1 Gene

Gene Tree for SLC9B1 (if available)
Gene Tree for SLC9B1 (if available)

Paralogs for SLC9B1 Gene

Paralogs for SLC9B1 Gene

(2) SIMAP similar genes for SLC9B1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC9B1: view

Variants for SLC9B1 Gene

Sequence variations from dbSNP and Humsavar for SLC9B1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs63749888 pathogenic, Wolfram syndrome 2 102,885,221(-) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1057520144 uncertain-significance, not provided 102,885,336(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000026364 -- 103,007,153(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000041969 -- 102,903,026(-) T/C intron_variant
rs1000072864 -- 102,903,599(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9B1 Gene

Variant ID Type Subtype PubMed ID
esv1026728 CNV deletion 17803354
esv2178050 CNV deletion 18987734
esv2588063 CNV deletion 19546169
esv2670006 CNV deletion 23128226
esv2678594 CNV deletion 23128226
esv2728081 CNV deletion 23290073
esv2759270 CNV gain 17122850
esv3564366 CNV deletion 23714750
esv3569636 CNV loss 25503493
esv3601623 CNV loss 21293372
esv3601625 CNV loss 21293372
esv988357 CNV deletion 20482838
nsv10542 CNV loss 18304495
nsv1072422 CNV deletion 25765185
nsv1123825 CNV deletion 24896259
nsv1141461 CNV duplication 24896259
nsv436415 CNV deletion 17901297
nsv4445 CNV insertion 18451855
nsv461598 CNV loss 19166990
nsv508300 CNV deletion 20534489
nsv513156 CNV loss 21212237
nsv528680 CNV loss 19592680
nsv594957 CNV loss 21841781
nsv594978 CNV loss 21841781
nsv830021 CNV loss 17160897
nsv950370 CNV duplication 24416366
nsv966304 CNV duplication 23825009
nsv967779 CNV duplication 23825009
nsv967781 CNV duplication 23825009

Variation tolerance for SLC9B1 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC9B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9B1 Gene

Disorders for SLC9B1 Gene

Additional Disease Information for SLC9B1

No disorders were found for SLC9B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC9B1 Gene

Publications for SLC9B1 Gene

  1. Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis. (PMID: 16850186) Ye G … Yu L (Molecular biology reports 2006) 2 3 4 58
  2. Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene. (PMID: 25701605) Kumar PL … James PF (Gene 2015) 3 58
  3. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung ML … Jeang KT (The Journal of biological chemistry 2009) 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SLC9B1 Gene

Sources for SLC9B1 Gene

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