Free for academic non-profit institutions. Other users need a Commercial license
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
SLC9A8 (Solute Carrier Family 9 Member A8) is a Protein Coding gene. Diseases associated with SLC9A8 include Christianson Syndrome and Renal Tubular Acidosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include solute:proton antiporter activity and potassium:proton antiporter activity. An important paralog of this gene is SLC9A7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015297 | antiporter activity | IEA | -- |
GO:0015299 | solute:proton antiporter activity | IEA | -- |
GO:0015385 | sodium:proton antiporter activity | IBA | 21873635 |
GO:0015386 | potassium:proton antiporter activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005794 | Golgi apparatus | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | TAS | -- |
GO:0006812 | cation transport | IEA | -- |
GO:0006814 | sodium ion transport | IEA | -- |
GO:0006885 | regulation of pH | IEA | -- |
GO:0035725 | sodium ion transmembrane transport | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC9A8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC9A8 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC9A8 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC9A8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC9A8 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Slc9a8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc9a8 30 |
|
||
Chicken (Gallus gallus) |
Aves | SLC9A8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC9A8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc9a8 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | slc9a8 30 31 |
|
OneToOne | |
wufj61b02 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009446 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Nhe1 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | nhx-8 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NHX1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | NHX6 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0286400 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5713 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2722489 | CNV | deletion | 23290073 |
esv2722490 | CNV | deletion | 23290073 |
esv2722491 | CNV | deletion | 23290073 |
esv3646017 | CNV | gain | 21293372 |
esv3646034 | CNV | gain | 21293372 |
esv3646036 | CNV | gain | 21293372 |
esv3646037 | CNV | gain | 21293372 |
nsv1131593 | CNV | deletion | 24896259 |
nsv1138966 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
christianson syndrome |
|
|
renal tubular acidosis |
|
|
corneal dystrophy, band-shaped |
|
|
inflammatory diarrhea |
|
|
diarrhea |
|
|