Aliases for SLC9A7 Gene
External Ids for SLC9A7 Gene
Previous GeneCards Identifiers for SLC9A7 Gene
This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
GeneCards Summary for SLC9A7 Gene
SLC9A7 (Solute Carrier Family 9 Member A7) is a Protein Coding gene. Diseases associated with SLC9A7 include Intellectual Developmental Disorder, X-Linked 108 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and sodium:proton antiporter activity. An important paralog of this gene is SLC9A6.
UniProtKB/Swiss-Prot Summary for SLC9A7 Gene
Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH.