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Aliases for SLC9A4 Gene
Aliases for SLC9A4 Gene
External Ids for SLC9A4 Gene
- HGNC: 11077
- NCBI Entrez Gene: 389015
- Ensembl: ENSG00000180251
- OMIM®: 600531
- UniProtKB/Swiss-Prot: Q6AI14
Previous GeneCards Identifiers for SLC9A4 Gene
- GC02U990082
- GC02P102745
- GC02P103089
- GC02P096854
Summaries for SLC9A4 Gene
GeneCards Summary for SLC9A4 Gene
SLC9A4 (Solute Carrier Family 9 Member A4) is a Protein Coding gene. Diseases associated with SLC9A4 include Pseudohypoaldosteronism, Type I, Autosomal Recessive. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include solute:proton antiporter activity and sodium:proton antiporter activity. An important paralog of this gene is SLC9A2.
UniProtKB/Swiss-Prot Summary for SLC9A4 Gene
-
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).
Additional gene information for SLC9A4 Gene
- HGNC (11077)
- NCBI Entrez Gene (389015)
- Ensembl (ENSG00000180251)
- OMIM® (600531)
- UniProtKB/Swiss-Prot (Q6AI14)
- Open Targets Platform(ENSG00000180251)
- Search for SLC9A4 at DataMed
- Search for SLC9A4 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC9A4 Gene
Genomics for SLC9A4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC9A4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC9A4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC9A4
- Top Transcription factor binding sites by QIAGEN in the SLC9A4 gene promoter:
-
- AML1a
- AREB6
- ATF-2
- c-Jun
- LCR-F1
- Nkx6-1
- S8
- TGIF
Genomic Locations for SLC9A4 Gene
Latest Assembly
- chr2:102,473,226-102,533,974
- (GRCh38/hg38)
- Size:
- 60,749 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:103,089,685-103,150,431
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 60,747 bases
- Orientation:
- Plus strand
- chr2:103,089,762-103,150,431
- (GRCh37/hg19 by Ensembl)
- Size:
- 60,670 bases
- Orientation:
- Plus strand
Genomic View for SLC9A4 Gene
Genes around SLC9A4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q12.1 by HGNC
- 2q12.1 by Entrez Gene
- 2q12.1 by Ensembl
SLC9A4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC9A4 Gene
Proteins for SLC9A4 Gene
-
Protein details for SLC9A4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6AI14-SL9A4_HUMAN
- Recommended name:
- Sodium/hydrogen exchanger 4
- Protein Accession:
- Q6AI14
- Q69YK0
Protein attributes for SLC9A4 Gene
- Size:
- 798 amino acids
- Molecular mass:
- 89814 Da
- Quaternary structure:
-
- Interacts with CHP1 and CHP2.
Post-translational modifications for SLC9A4 Gene
- May be phosphorylated.
-
Glycosylation at Asn342
- NX_Q6AI14 (NX_Q6AI14-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SLC9A4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for SLC9A4
- Invitrogen Antibodies for SLC9A4 (AFLGC-SLC9A4)
- antibodies-online: Show 5 available SLC9A4 Antibodies ranked by validation data
- Compare Top SLC9A4 Antibodies
-
Quality Products:
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC9A4
- Origene Custom Protein Services for SLC9A4
- Novus Biologicals proteins for SLC9A4
- antibodies-online: Show 4 available SLC9A4 Proteins ranked by validation data
- Compare Top SLC9A4 Proteins
-
Quality Products:
Assay products for research
No data available for DME Specific Peptides for SLC9A4 Gene
Domains & Families for SLC9A4 Gene
Gene Families for SLC9A4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC9A4 Gene
- InterPro:
- Blocks:
-
- Na+/H+ exchanger signature
- Sodium/hydrogen exchanger
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC9A4 Gene
- GenScript: Design optimal peptide antigens:
-
- Solute carrier family 9 member 4 (SL9A4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6AI14UniProtKB/Swiss-Prot:
SL9A4_HUMAN :- Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
- Family:
-
- Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Function for SLC9A4 Gene
Molecular function for SLC9A4 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).
- GENATLAS Biochemistry:
- solute carrier protein family 9 (sodium/hydrogen exchange),member 4,involved in intracellular pH regulation and cell volume,isoform 4,expressed in stomach,kidney,brain,uterus,skeletalmuscle
Phenotypes From GWAS Catalog for SLC9A4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015297 | antiporter activity | IEA | -- |
| GO:0015299 | solute:proton antiporter activity | IEA | -- |
| GO:0015385 | sodium:proton antiporter activity | IBA | 21873635 |
| GO:0015386 | potassium:proton antiporter activity | IBA | 21873635 |
Phenotypes for SLC9A4 Gene
- MGI mutant phenotypes for SLC9A4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SLC9A4:
Animal Models for SLC9A4 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for SLC9A4
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC9A4 - Starting at $85 >
- * SLC9A4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC9A4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC9A4
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC9A4
miRNA for SLC9A4 Gene
- miRTarBase miRNAs that target SLC9A4
-
- hsa-miR-374b-5p (MIRT531051)
- hsa-miR-374a-5p (MIRT531052)
- hsa-miR-5692c (MIRT531053)
- hsa-miR-5692b (MIRT531054)
- hsa-miR-369-3p (MIRT531055)
- hsa-miR-548l (MIRT531056)
- hsa-miR-8054 (MIRT531057)
- hsa-miR-548k (MIRT531058)
- hsa-miR-548av-5p (MIRT531059)
- hsa-miR-559 (MIRT531060)
- hsa-miR-548y (MIRT531061)
- hsa-miR-548w (MIRT531062)
- hsa-miR-548o-5p (MIRT531063)
- hsa-miR-548j-5p (MIRT531064)
- hsa-miR-548i (MIRT531065)
- hsa-miR-548h-5p (MIRT531066)
- hsa-miR-548d-5p (MIRT531067)
- hsa-miR-548c-5p (MIRT531068)
- hsa-miR-548bb-5p (MIRT531069)
- hsa-miR-548b-5p (MIRT531070)
- hsa-miR-548ay-5p (MIRT531071)
- hsa-miR-548au-5p (MIRT531072)
- hsa-miR-548as-5p (MIRT531073)
- hsa-miR-548ar-5p (MIRT531074)
- hsa-miR-548aq-5p (MIRT531075)
- hsa-miR-548ap-5p (MIRT531076)
- hsa-miR-548am-5p (MIRT531077)
- hsa-miR-548ak (MIRT531078)
- hsa-miR-548ae-5p (MIRT531079)
- hsa-miR-548ad-5p (MIRT531080)
- hsa-miR-548ab (MIRT531081)
- hsa-miR-548a-5p (MIRT531082)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC9A4
- Browse OriGene Inhibitory RNA Products For SLC9A4
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Clone products for research
- Applied Biological Materials (abm): Clones for SLC9A4 - Starting at $45 >
- * SLC9A4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SLC9A4
- Addgene plasmids for SLC9A4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC9A4
Cell Lines for research
-
Horizon Cell Lines for SLC9A4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC9A4 Gene
Localization for SLC9A4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC9A4 Gene
- Apical cell membrane. Multi-pass membrane protein. Basolateral cell membrane. Multi-pass membrane protein. Cytoplasmic granule membrane. Multi-pass membrane protein. Note=Found in zymogen granule membranes. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005774 | vacuolar membrane | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for SLC9A4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 2 | Salivary secretion | ||
| 3 | ADP signalling through P2Y purinoceptor 12 | ||
| 4 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
| 5 | TCR Signaling (Qiagen) |
PDGF Pathway
.39
|
|
Pathways by source for SLC9A4 Gene
4 Reactome pathways for SLC9A4 Gene
1 PharmGKB pathway for SLC9A4 Gene
1 KEGG pathway for SLC9A4 Gene
2 Qiagen pathways for SLC9A4 Gene
- Intracellular Calcium Signaling
- PDGF Pathway
Interacting Proteins for SLC9A4 Gene
GPS-Prot Interaction Network for SLC9A4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001696 | gastric acid secretion | IEA | -- |
| GO:0002064 | epithelial cell development | IEA | -- |
| GO:0006811 | ion transport | TAS | -- |
| GO:0006812 | cation transport | IEA | -- |
| GO:0006814 | sodium ion transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC9A4 Gene
Transcripts for SLC9A4 Gene
mRNA/cDNA for SLC9A4 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000295269 4215 nts (view in UCSC)
- ENST00000492154 818 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC9A4 - Starting at $85 >
- * SLC9A4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC9A4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC9A4
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC9A4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC9A4
- Browse OriGene Inhibitory RNA Products For SLC9A4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC9A4
Clone products for research
- Applied Biological Materials (abm): Clones for SLC9A4 - Starting at $45 >
- * SLC9A4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SLC9A4
- Addgene plasmids for SLC9A4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC9A4
Relevant External Links for SLC9A4 Gene
- GeneLoc Exon Structure for
- SLC9A4
Expression for SLC9A4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for SLC9A4 Gene
This gene is overexpressed in Stomach (x39.8) and Kidney - Cortex (x4.9).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC9A4
SOURCE GeneReport for Unigene cluster for SLC9A4 Gene:
Hs.447686Evidence on tissue expression from TISSUES for SLC9A4 Gene
- Stomach(4.5)
- Skin(4.2)
- Liver(3.4)
- Blood(2.8)
- Kidney(2.3)
Primer products for research
-
OriGene qPCR primer pairs for SLC9A4
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC9A4 Gene
Orthologs for SLC9A4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC9A4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC9A4 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Slc9a4 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | SLC9A4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Slc9a4 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC9A4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC9A4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC9A4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc9a4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | slc9a2 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Nhe2 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | nhx-1 31 |
|
ManyToMany | |
| nhx-9 31 |
|
ManyToMany | |||
| nhx-6 31 |
|
ManyToMany | |||
| nhx-2 31 |
|
ManyToMany | |||
| nhx-3 31 |
|
ManyToMany |
- Species where no ortholog for SLC9A4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC9A4 Gene
- ENSEMBL:
- Gene Tree for SLC9A4 (if available)
- TreeFam:
- Gene Tree for SLC9A4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC9A4: view image
Paralogs for SLC9A4 Gene
Variants for SLC9A4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC9A4 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs79378995 | Benign: not provided | 102,473,809(+) |
T/C NM_001011552.4(SLC9A4):c.50T>C (p.Leu17Pro) |
MISSENSE | |
| rs17027275 | - |
p.Gly116Ser |
|||
| rs6742280 | - |
p.Ile581Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2667694 | CNV | deletion | 23128226 |
| esv3583992 | CNV | loss | 25503493 |
| esv3591793 | CNV | loss | 21293372 |
| nsv1160831 | CNV | duplication | 26073780 |
| nsv523406 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.40;
63.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC9A4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9A4 Gene
Disorders for SLC9A4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pseudohypoaldosteronism, type i, autosomal recessive |
|
|
Search SLC9A4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC9A4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC9A4 Gene
Publications for SLC9A4 Gene
- Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 41
- Newly identified genetic risk variants for celiac disease related to the immune response. (PMID: 18311140) Hunt KA … van Heel DA (Nature genetics 2008) 3 41
- NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. (PMID: 17943310) Beltrán AR … Malnic G (Pflugers Archiv : European journal of physiology 2008) 3 23
- Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. (PMID: 8199403) Szpirer C … Orlowski J (Mammalian genome : official journal of the International Mammalian Genome Society 1994) 2 3
- Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef. (PMID: 24874739) Hashimoto M … Suzu S (Cell death & disease 2014) 3
ExternalLinks
Products for SLC9A4 Gene
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- Taconic Biosciences Mouse Models for SLC9A4
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- Genetically Engineered Models Available Immediately
- Humanized Mice
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- antibodies-online: Show 5 available SLC9A4 Antibodies ranked by validation data
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC9A4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SLC9A4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC9A4
Sources for SLC9A4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB