Aliases for SLC9A3 Gene
External Ids for SLC9A3 Gene
Previous HGNC Symbols for SLC9A3 Gene
Previous GeneCards Identifiers for SLC9A3 Gene
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
GeneCards Summary for SLC9A3 Gene
SLC9A3 (Solute Carrier Family 9 Member A3) is a Protein Coding gene. Diseases associated with SLC9A3 include Diarrhea 8, Secretory Sodium, Congenital and Diarrhea 3, Secretory Sodium, Congenital, With Or Without Other Congenital Anomalies. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and sodium:proton antiporter activity. An important paralog of this gene is SLC9A5.
UniProtKB/Swiss-Prot Summary for SLC9A3 Gene
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.