Aliases for SLC9A2 Gene
External Ids for SLC9A2 Gene
Previous HGNC Symbols for SLC9A2 Gene
Previous GeneCards Identifiers for SLC9A2 Gene
This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The encoded protein is localized to the apical membrane and is involved in apical absorption of sodium. [provided by RefSeq, Jun 2016]
GeneCards Summary for SLC9A2 Gene
SLC9A2 (Solute Carrier Family 9 Member A2) is a Protein Coding gene. Diseases associated with SLC9A2 include Diarrhea 1, Secretory Chloride, Congenital and Motility-Related Diarrhea. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include solute:proton antiporter activity and sodium:proton antiporter activity. An important paralog of this gene is SLC9A4.
UniProtKB/Swiss-Prot Summary for SLC9A2 Gene
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.