Aliases for SLC8B1 Gene
- Solute Carrier Family 8 Member B1 2 3 4 5
- NCKX6 2 3 4
- NCLX 2 3 4
- Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 6 2 3
- Solute Carrier Family 24 (Sodium/Lithium/Calcium Exchanger), Member 6 2 3
- Solute Carrier Family 8 (Sodium/Lithium/Calcium Exchanger), Member B1 2 3
- Sodium/Calcium Exchanger Protein, Mitochondrial 3 4
External Ids for SLC8B1 Gene
Previous HGNC Symbols for SLC8B1 Gene
Previous GeneCards Identifiers for SLC8B1 Gene
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC8B1 Gene
SLC8B1 (Solute Carrier Family 8 Member B1) is a Protein Coding gene. Diseases associated with SLC8B1 include Cataract 3, Multiple Types and Wolf-Hirschhorn Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential.
UniProtKB/Swiss-Prot Summary for SLC8B1 Gene
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069).