Aliases for SLC8A2 Gene
External Ids for SLC8A2 Gene
Previous GeneCards Identifiers for SLC8A2 Gene
GeneCards Summary for SLC8A2 Gene
SLC8A2 (Solute Carrier Family 8 Member A2) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is SLC8A3.
UniProtKB/Swiss-Prot for SLC8A2 Gene
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.