Aliases for SLC8A2 Gene
External Ids for SLC8A2 Gene
Previous GeneCards Identifiers for SLC8A2 Gene
GeneCards Summary for SLC8A2 Gene
SLC8A2 (Solute Carrier Family 8 Member A2) is a Protein Coding gene. Diseases associated with SLC8A2 include Ischemia and Schnyder Corneal Dystrophy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is SLC8A3.
UniProtKB/Swiss-Prot Summary for SLC8A2 Gene
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.