Aliases for SLC7A6OS Gene

Aliases for SLC7A6OS Gene

  • Solute Carrier Family 7 Member 6 Opposite Strand 2 3 5
  • Probable RNA Polymerase II Nuclear Localization Protein SLC7A6OS 3 4
  • Solute Carrier Family 7 Member 6 Opposite Strand Transcript 3 4
  • ADAMS Proteinase-Related Protein 3 4
  • Solute Carrier Family 7, Member 6 Opposite Strand 2
  • Protein SLC7A6OS 3

External Ids for SLC7A6OS Gene

Previous GeneCards Identifiers for SLC7A6OS Gene

  • GC16M066890
  • GC16M068332
  • GC16M054207
  • GC16M068320

Summaries for SLC7A6OS Gene

GeneCards Summary for SLC7A6OS Gene

SLC7A6OS (Solute Carrier Family 7 Member 6 Opposite Strand) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for SLC7A6OS Gene

Additional gene information for SLC7A6OS Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC7A6OS Gene

Genomics for SLC7A6OS Gene

GeneHancer (GH) Regulatory Elements for SLC7A6OS Gene

Promoters and enhancers for SLC7A6OS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC7A6OS

Top Transcription factor binding sites by QIAGEN in the SLC7A6OS gene promoter:
  • COMP1
  • ER-alpha
  • GATA-1
  • GATA-2
  • GR
  • GR-alpha
  • NCX
  • NF-E2
  • NF-E2 p45
  • Pax-5

Genomic Locations for SLC7A6OS Gene

Genomic Locations for SLC7A6OS Gene
26,463 bases
Minus strand
26,463 bases
Minus strand

Genomic View for SLC7A6OS Gene

Genes around SLC7A6OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A6OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A6OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A6OS Gene

Proteins for SLC7A6OS Gene

  • Protein details for SLC7A6OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable RNA polymerase II nuclear localization protein SLC7A6OS
    Protein Accession:
    Secondary Accessions:
    • Q8TCZ3
    • Q9H8R8

    Protein attributes for SLC7A6OS Gene

    309 amino acids
    Molecular mass:
    35028 Da
    Quaternary structure:
    No Data Available
    • When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells.
    • Sequence=AAL79958.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for SLC7A6OS Gene

Post-translational modifications for SLC7A6OS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A6OS Gene

No data available for DME Specific Peptides for SLC7A6OS Gene

Domains & Families for SLC7A6OS Gene

Gene Families for SLC7A6OS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLC7A6OS Gene


Suggested Antigen Peptide Sequences for SLC7A6OS Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 7 member 6 opposite strand transcript (S7A6O_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IWR1/SLC7A6OS family.
  • Belongs to the IWR1/SLC7A6OS family.
genes like me logo Genes that share domains with SLC7A6OS: view

Function for SLC7A6OS Gene

Molecular function for SLC7A6OS Gene

UniProtKB/Swiss-Prot Function:
Directs RNA polymerase II nuclear import.

Phenotypes From GWAS Catalog for SLC7A6OS Gene

genes like me logo Genes that share phenotypes with SLC7A6OS: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC7A6OS Gene

Localization for SLC7A6OS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A6OS gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SLC7A6OS: view

Pathways & Interactions for SLC7A6OS Gene

PathCards logo

SuperPathways for SLC7A6OS Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC7A6OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0015031 protein transport IEA --
GO:0032502 developmental process IBA 21873635
genes like me logo Genes that share ontologies with SLC7A6OS: view

No data available for Pathways by source and SIGNOR curated interactions for SLC7A6OS Gene

Drugs & Compounds for SLC7A6OS Gene

No Compound Related Data Available

Transcripts for SLC7A6OS Gene

mRNA/cDNA for SLC7A6OS Gene

6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A6OS Gene

No ASD Table

Relevant External Links for SLC7A6OS Gene

GeneLoc Exon Structure for

Expression for SLC7A6OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC7A6OS Gene

Protein differential expression in normal tissues from HIPED for SLC7A6OS Gene

This gene is overexpressed in Blymphocyte (25.7), Peripheral blood mononuclear cells (16.0), Retina (12.7), and Colon (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC7A6OS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC7A6OS

SOURCE GeneReport for Unigene cluster for SLC7A6OS Gene:


Evidence on tissue expression from TISSUES for SLC7A6OS Gene

  • Adrenal gland(4.2)
  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with SLC7A6OS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A6OS Gene

Orthologs for SLC7A6OS Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC7A6OS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC7A6OS 31 30
  • 99.46 (n)
(Canis familiaris)
Mammalia SLC7A6OS 31 30
  • 84.31 (n)
(Bos Taurus)
Mammalia SLC7A6OS 31 30
  • 80.72 (n)
(Rattus norvegicus)
Mammalia Slc7a6os 30
  • 80.15 (n)
(Mus musculus)
Mammalia Slc7a6os 17 31 30
  • 79.93 (n)
(Monodelphis domestica)
Mammalia SLC7A6OS 31
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia SLC7A6OS 31
  • 32 (a)
(Gallus gallus)
Aves SLC7A6OS 31 30
  • 63.46 (n)
(Anolis carolinensis)
Reptilia SLC7A6OS 31
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a6os 30
  • 55.26 (n)
(Danio rerio)
Actinopterygii slc7a6os 31 30
  • 58.56 (n)
Dr.12894 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2841 31
  • 24 (a)
Species where no ortholog for SLC7A6OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC7A6OS Gene

Gene Tree for SLC7A6OS (if available)
Gene Tree for SLC7A6OS (if available)
Evolutionary constrained regions (ECRs) for SLC7A6OS: view image

Paralogs for SLC7A6OS Gene

No data available for Paralogs for SLC7A6OS Gene

Variants for SLC7A6OS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC7A6OS Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
714707 Likely Benign: not provided 68,304,055(-) C/T MISSENSE_VARIANT
790166 Benign: not provided 68,310,857(-) C/T MISSENSE_VARIANT
rs11548855 - p.Tyr220Cys
rs35800405 - p.Val24Met
rs3803650 - p.Gly45Asp

Additional dbSNP identifiers (rs#s) for SLC7A6OS Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC7A6OS Gene

Variant ID Type Subtype PubMed ID
nsv510691 CNV deletion 20534489
nsv519368 CNV loss 19592680

Variation tolerance for SLC7A6OS Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC7A6OS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A6OS Gene

Disorders for SLC7A6OS Gene

Additional Disease Information for SLC7A6OS

No disorders were found for SLC7A6OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC7A6OS Gene

Publications for SLC7A6OS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. (PMID: 28561026) Cloutier P … Coulombe B (Nature communications 2017) 3 54
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54

Products for SLC7A6OS Gene

Sources for SLC7A6OS Gene