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Aliases for SLC7A5 Gene
Aliases for SLC7A5 Gene
- Solute Carrier Family 7 Member 5 2 3 4 5
- MPE16 2 3 4
- LAT1 2 3 4
- E16 2 3 4
- Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 5 2 3
- Large Neutral Amino Acids Transporter Small Subunit 1 3 4
- L-Type Amino Acid Transporter 1 3 4
- Integral Membrane Protein E16 3 4
- CD98 Light Chain 3 4
- 4F2 Light Chain 3 4
External Ids for SLC7A5 Gene
- HGNC: 11063
- Entrez Gene: 8140
- Ensembl: ENSG00000103257
- OMIM: 600182
- UniProtKB: Q01650
Previous GeneCards Identifiers for SLC7A5 Gene
- GC16M079198
- GC16M088894
- GC16M087604
- GC16M087645
- GC16M086421
- GC16M087863
Summaries for SLC7A5 Gene
GeneCards Summary for SLC7A5 Gene
SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Phenylketonuria and Lysinuric Protein Intolerance. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and antiporter activity. An important paralog of this gene is SLC7A8.
UniProtKB/Swiss-Prot Summary for SLC7A5 Gene
-
The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).
Additional gene information for SLC7A5 Gene
- HGNC(11063)
- Entrez Gene(8140)
- Ensembl(ENSG00000103257)
- OMIM(600182)
- UniProtKB(Q01650)
- Open Targets Platform(ENSG00000103257)
- Monarch Initiative
- Search for SLC7A5 at DataMed
- Search for SLC7A5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC7A5 Gene
Genomics for SLC7A5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC7A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC7A5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC7A5
- Top Transcription factor binding sites by QIAGEN in the SLC7A5 gene promoter:
-
- CP2
- FOXO3
- FOXO3a
- FOXO3b
- NF-1
- NF-1/L
- Pax-4a
- Pax-5
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for SLC7A5 Gene
Genomic Locations for SLC7A5 Gene
- chr16:87,830,022-87,869,507
- (GRCh38/hg38)
- Size:
- 39,486 bases
- Orientation:
- Minus strand
- chr16:87,863,629-87,903,100
- (GRCh37/hg19)
- Size:
- 39,472 bases
- Orientation:
- Minus strand
Genomic View for SLC7A5 Gene
Genes around SLC7A5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.2 by HGNC
- 16q24.2 by Entrez Gene
- 16q24.2 by Ensembl
SLC7A5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC7A5 Gene
Proteins for SLC7A5 Gene
-
Protein details for SLC7A5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01650-LAT1_HUMAN
- Recommended name:
- Large neutral amino acids transporter small subunit 1
- Protein Accession:
- Q01650
- Q8IV97
- Q9UBN8
- Q9UP15
- Q9UQC0
Protein attributes for SLC7A5 Gene
- Size:
- 507 amino acids
- Molecular mass:
- 55010 Da
- Quaternary structure:
-
- Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:9751058, PubMed:25998567, PubMed:30867591). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).
- Miscellaneous:
-
- The uptake of leucine, tyrosine and tryptophan is inhibited by the different iodothyronines, in particular T3. Leucine transport is also inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine and cysteine) and by glutamine and asparagine. The uptake of T3 is almost completely blocked by coincubation with leucine, tryptophan, tyrosine, and phenylalanine, or 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH). Methionine uptake was inhibited by the L-system substrates L-leucine, BCH, L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO. Tyrosine uptake in fibroblasts was inhibited by D-methionine, and methyl-aminoisobutyric acid (MeAIB).
Protein Expression for SLC7A5 Gene
Post-translational modifications for SLC7A5 Gene
Other Protein References for SLC7A5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SLC7A5 / CD98 Light Chain Antibody (LS-A3406) and SLC7A5 / CD98 Light Chain Antibody (LS-A3404)
- G Biosciences Immunotag™ SLC7A5 Antibody
- Novus Biologicals Antibodies for SLC7A5
- Invitrogen Antibodies for SLC7A5 (AFLGC-SLC7A5)
-
Biorbyt antibodies for SLC7A5
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC7A5
Protein Products
-
OriGene Purified Proteins for SLC7A5
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC7A5
- Origene Custom Protein Services for SLC7A5
- Novus Biologicals proteins for SLC7A5
-
Abcam proteins for SLC7A5
Assay Products
- antibodies-online: Show 5 available SLC7A5 Elisa Kits ranked by validation data
- Compare Top SLC7A5 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC7A5 Gene
Domains & Families for SLC7A5 Gene
Gene Families for SLC7A5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC7A5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC7A5 Gene
- GenScript: Design optimal peptide antigens:
-
- y+ system cationic amino acid transporter (LAT1_HUMAN)
- Large neutral amino acids transporter 1 (Q2MCL6_HUMAN)
- Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 5 (Q8IV97_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01650UniProtKB/Swiss-Prot:
LAT1_HUMAN :- Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
- Family:
-
- Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Function for SLC7A5 Gene
Molecular function for SLC7A5 Gene
- UniProtKB/Swiss-Prot Function:
- The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).
- UniProtKB/Swiss-Prot Induction:
- Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=7.9 uM for T4 (in the presence of choline chloride) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=0.8 uM for T3 (in the presence of choline chloride) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=12.5 uM for reverse triiodothyronine (rT3) (in the presence of choline chloride) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=7.9 uM for 3,3'-diiodothyronine (in the presence of choline chloride) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=46 uM for leucine (in the presence of choline chloride) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=19 uM for tryptophan (in the presence of choline chloride) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=32 uM for L-leucine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=10 mM for L-alanine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=2.2 mM for L-glutamine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=35 uM for L-histidine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=740 uM for L-phenylalanine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=98 uM for MeHg-L-cysteine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=99 uM for methionine {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=55.2 uM for phenylalanine (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=60.4 uM for tyrosine (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=16.4 uM for tyrosine (in human fibroblasts) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=138 uM for Dopa (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=96.5 uM for 3-O-methyldopa (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=153 uM for alpha-methyltyrosine (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=216 uM for alpha-methyldopa (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=191 uM for gabapentin (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=7.3 uM for triiodothyronine (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=162 uM for thyroxine (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=75.3 uM for melphanan (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359}; KM=156 uM for BCH (in T24 human bladder carcinoma cells) {ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:18262359};
- GENATLAS Biochemistry:
- solute carrier family 7,member 5,40kDa,human cell surface glycoprotein 4F2 light chain,heterodimerizing with the cell surface glycoprotein 4F2 heavy chain (CD98) to form a complex mediating L-type (sodium independent exchange) of large neutral amino acids transport,not expressed in the intestine
Phenotypes From GWAS Catalog for SLC7A5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25998567 |
| GO:0015171 | amino acid transmembrane transporter activity | ISS | -- |
| GO:0015179 | L-amino acid transmembrane transporter activity | IEA,IBA | 21873635 |
| GO:0015190 | L-leucine transmembrane transporter activity | IDA | 30867591 |
| GO:0015196 | L-tryptophan transmembrane transporter activity | IDA | 30867591 |
Phenotypes for SLC7A5 Gene
- MGI mutant phenotypes for SLC7A5:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SLC7A5:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Increased G1 DNA content
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Increased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for SLC7A5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC7A5
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC7A5 - Select products 50% OFF >
- * SLC7A5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC7A5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC7A5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC7A5
miRNA for SLC7A5 Gene
- miRTarBase miRNAs that target SLC7A5
-
- hsa-miR-626 (MIRT004144)
- hsa-miR-7-5p (MIRT004528)
- hsa-miR-663a (MIRT006088)
- hsa-miR-126-3p (MIRT006679)
- mmu-miR-425-5p (MIRT008673)
- mmu-miR-19b-3p (MIRT012460)
- mmu-miR-30e-5p (MIRT013343)
- hsa-miR-193b-3p (MIRT016508)
- hsa-miR-16-5p (MIRT031833)
- hsa-miR-296-3p (MIRT038496)
- hsa-miR-671-5p (MIRT039269)
- hsa-miR-193a-3p (MIRT054240)
- hsa-miR-1226-5p (MIRT075861)
- hsa-miR-194-3p (MIRT144690)
- hsa-miR-5693 (MIRT144706)
- hsa-miR-205-3p (MIRT467580)
- hsa-miR-4531 (MIRT467581)
- hsa-miR-3911 (MIRT467582)
- hsa-miR-7847-3p (MIRT467583)
- hsa-miR-223-3p (MIRT467584)
- hsa-miR-4697-3p (MIRT467585)
- hsa-miR-504-3p (MIRT467586)
- hsa-miR-5703 (MIRT467587)
- hsa-miR-4516 (MIRT467588)
- hsa-miR-4434 (MIRT467589)
- hsa-miR-184 (MIRT467590)
- hsa-miR-574-5p (MIRT467591)
- hsa-miR-4475 (MIRT467592)
- hsa-miR-551b-5p (MIRT467593)
- hsa-miR-548c-3p (MIRT467594)
- hsa-miR-3611 (MIRT467595)
- hsa-miR-1260b (MIRT467596)
- hsa-miR-1260a (MIRT467597)
- hsa-miR-765 (MIRT467598)
- hsa-miR-658 (MIRT467599)
- hsa-miR-6499-3p (MIRT467600)
- hsa-miR-769-5p (MIRT467601)
- hsa-miR-6786-3p (MIRT467602)
- hsa-miR-4734 (MIRT467603)
- hsa-miR-532-3p (MIRT467604)
- hsa-miR-1539 (MIRT467605)
- hsa-miR-1224-3p (MIRT467606)
- hsa-miR-4302 (MIRT467607)
- hsa-miR-708-5p (MIRT467608)
- hsa-miR-3139 (MIRT467609)
- hsa-miR-28-5p (MIRT467610)
- hsa-miR-6854-5p (MIRT467611)
- hsa-miR-5197-3p (MIRT467612)
- hsa-miR-1295a (MIRT467613)
- hsa-miR-8059 (MIRT467614)
- hsa-miR-4471 (MIRT467615)
- hsa-miR-1292-5p (MIRT467616)
- hsa-miR-3135a (MIRT467617)
- hsa-miR-5008-5p (MIRT467618)
- hsa-miR-4260 (MIRT467619)
- hsa-miR-1227-5p (MIRT467620)
- hsa-miR-3189-3p (MIRT467621)
- hsa-miR-6876-5p (MIRT467622)
- hsa-miR-4476 (MIRT467623)
- hsa-miR-30e-5p (MIRT467624)
- hsa-miR-30d-5p (MIRT467625)
- hsa-miR-30c-5p (MIRT467626)
- hsa-miR-30b-5p (MIRT467627)
- hsa-miR-30a-5p (MIRT467628)
- hsa-miR-5196-5p (MIRT467629)
- hsa-miR-4747-5p (MIRT467630)
- hsa-miR-4668-5p (MIRT467631)
- hsa-miR-7155-3p (MIRT467632)
- hsa-miR-6797-5p (MIRT467633)
- hsa-miR-3136-3p (MIRT467634)
- hsa-miR-1249-5p (MIRT467635)
- hsa-miR-3148 (MIRT467636)
- hsa-miR-3202 (MIRT467637)
- hsa-miR-7515 (MIRT467638)
- hsa-miR-7160-3p (MIRT467639)
- hsa-miR-9500 (MIRT467640)
- hsa-miR-5584-5p (MIRT467641)
- hsa-miR-4779 (MIRT467642)
- hsa-miR-6891-5p (MIRT467643)
- hsa-miR-3173-3p (MIRT467644)
- hsa-miR-6834-5p (MIRT486079)
- hsa-miR-6728-5p (MIRT486080)
- hsa-miR-6780a-5p (MIRT486081)
- hsa-miR-6779-5p (MIRT486082)
- hsa-miR-3689c (MIRT486083)
- hsa-miR-3689b-3p (MIRT486084)
- hsa-miR-3689a-3p (MIRT486085)
- hsa-miR-30b-3p (MIRT486086)
- hsa-miR-1273h-5p (MIRT486087)
- hsa-miR-6799-5p (MIRT486088)
- hsa-miR-5187-5p (MIRT486089)
- hsa-miR-6883-5p (MIRT486090)
- hsa-miR-6785-5p (MIRT486091)
- hsa-miR-4728-5p (MIRT486092)
- hsa-miR-149-3p (MIRT486093)
- hsa-miR-7106-5p (MIRT486094)
- hsa-miR-8052 (MIRT486095)
- hsa-miR-3199 (MIRT486096)
- hsa-miR-92b-5p (MIRT486097)
- hsa-miR-4515 (MIRT486098)
- hsa-miR-6875-5p (MIRT486099)
- hsa-miR-3126-5p (MIRT486100)
- hsa-miR-6506-5p (MIRT486101)
- hsa-miR-619-5p (MIRT486102)
- hsa-miR-4285 (MIRT486103)
- hsa-miR-3192-5p (MIRT486104)
- hsa-miR-122-5p (MIRT501090)
- hsa-miR-7977 (MIRT503266)
- hsa-miR-493-3p (MIRT503267)
- hsa-miR-4691-3p (MIRT503268)
- hsa-miR-449b-3p (MIRT503269)
- hsa-miR-598-3p (MIRT503270)
- hsa-miR-186-5p (MIRT503271)
- hsa-miR-3133 (MIRT503272)
- hsa-miR-6734-5p (MIRT574430)
- hsa-miR-1255b-5p (MIRT574431)
- hsa-miR-1255a (MIRT574432)
- hsa-miR-6133 (MIRT574433)
- hsa-miR-6130 (MIRT574434)
- hsa-miR-6127 (MIRT574435)
- hsa-miR-6129 (MIRT574436)
- hsa-miR-4510 (MIRT574437)
- hsa-miR-4419a (MIRT574438)
- hsa-miR-5186 (MIRT574439)
- hsa-miR-6757-5p (MIRT574440)
- mmu-miR-694 (MIRT580869)
- hsa-miR-5096 (MIRT708352)
- hsa-miR-29b-2-5p (MIRT708353)
- hsa-miR-140-3p (MIRT708354)
- hsa-miR-6823-5p (MIRT708355)
- hsa-miR-513b-3p (MIRT708356)
- hsa-miR-195-5p (MIRT726508)
- hsa-miR-15b-5p (MIRT726509)
- hsa-miR-15a-5p (MIRT726511)
- hsa-miR-1237-5p (MIRT736322)
- hsa-miR-1264 (MIRT736685)
- hsa-miR-1273g-3p (MIRT736828)
- hsa-miR-1285-3p (MIRT737035)
- hsa-miR-132-5p (MIRT737409)
- hsa-miR-181a-2-3p (MIRT738020)
- hsa-miR-185-3p (MIRT738223)
- hsa-miR-1908-5p (MIRT738333)
- hsa-miR-214-3p (MIRT739002)
- hsa-miR-219b-5p (MIRT739065)
- hsa-miR-22-3p (MIRT739096)
- hsa-miR-24-1-5p (MIRT739211)
- hsa-miR-24-2-5p (MIRT739218)
- hsa-miR-296-5p (MIRT739526)
- hsa-miR-3065-3p (MIRT739708)
- hsa-miR-3154 (MIRT740424)
- hsa-miR-3155a (MIRT740436)
- hsa-miR-3155b (MIRT740447)
- hsa-miR-3179 (MIRT740755)
- hsa-miR-3180-3p (MIRT740790)
- hsa-miR-3180 (MIRT740830)
- hsa-miR-3187-3p (MIRT740909)
- hsa-miR-3187-5p (MIRT740930)
- hsa-miR-3196 (MIRT741088)
- hsa-miR-338-3p (MIRT741356)
- hsa-miR-33a-5p (MIRT741370)
- hsa-miR-33b-5p (MIRT741377)
- hsa-miR-3612 (MIRT741605)
- hsa-miR-3619-5p (MIRT741726)
- hsa-miR-3661 (MIRT741993)
- hsa-miR-3664-3p (MIRT742031)
- hsa-miR-3689d (MIRT742495)
- hsa-miR-383-3p (MIRT742801)
- hsa-miR-3929 (MIRT743079)
- hsa-miR-3934-3p (MIRT743092)
- hsa-miR-3937 (MIRT743133)
- hsa-miR-4264 (MIRT743495)
- hsa-miR-4267 (MIRT743522)
- hsa-miR-4270 (MIRT743600)
- hsa-miR-4271 (MIRT743641)
- hsa-miR-4419b (MIRT744246)
- hsa-miR-4435 (MIRT744425)
- hsa-miR-4436a (MIRT744442)
- hsa-miR-4441 (MIRT744567)
- hsa-miR-4443 (MIRT744594)
- hsa-miR-4459 (MIRT744844)
- hsa-miR-4478 (MIRT745085)
- hsa-miR-4481 (MIRT745125)
- hsa-miR-4488 (MIRT745245)
- hsa-miR-4530 (MIRT745972)
- hsa-miR-4650-5p (MIRT746524)
- hsa-miR-4663 (MIRT746717)
- hsa-miR-4690-5p (MIRT747079)
- hsa-miR-4697-5p (MIRT747248)
- hsa-miR-4700-3p (MIRT747270)
- hsa-miR-4701-5p (MIRT747309)
- hsa-miR-4704-3p (MIRT747320)
- hsa-miR-4706 (MIRT747342)
- hsa-miR-4711-5p (MIRT747446)
- hsa-miR-4716-3p (MIRT747505)
- hsa-miR-4722-5p (MIRT747625)
- hsa-miR-4723-5p (MIRT747670)
- hsa-miR-4725-3p (MIRT747722)
- hsa-miR-4745-5p (MIRT748196)
- hsa-miR-4749-5p (MIRT748322)
- hsa-miR-4755-3p (MIRT748371)
- hsa-miR-4781-5p (MIRT748802)
- hsa-miR-4796-3p (MIRT748975)
- hsa-miR-4797-5p (MIRT748987)
- hsa-miR-484 (MIRT749051)
- hsa-miR-485-5p (MIRT749081)
- hsa-miR-5000-3p (MIRT749329)
- hsa-miR-5189-5p (MIRT749891)
- hsa-miR-5195-5p (MIRT750002)
- hsa-miR-542-3p (MIRT750416)
- hsa-miR-548ag (MIRT750509)
- hsa-miR-548ai (MIRT750518)
- hsa-miR-548ba (MIRT750664)
- hsa-miR-548s (MIRT750791)
- hsa-miR-5698 (MIRT751303)
- hsa-miR-5700 (MIRT751333)
- hsa-miR-570-5p (MIRT751385)
- hsa-miR-586 (MIRT751549)
- hsa-miR-588 (MIRT751557)
- hsa-miR-604 (MIRT751639)
- hsa-miR-6085 (MIRT751812)
- hsa-miR-6087 (MIRT751922)
- hsa-miR-612 (MIRT752233)
- hsa-miR-6165 (MIRT752519)
- hsa-miR-625-5p (MIRT752606)
- hsa-miR-631 (MIRT752656)
- hsa-miR-647 (MIRT752764)
- hsa-miR-6509-3p (MIRT752983)
- hsa-miR-650 (MIRT753053)
- hsa-miR-6512-3p (MIRT753233)
- hsa-miR-6515-5p (MIRT753303)
- hsa-miR-665 (MIRT753657)
- hsa-miR-6720-5p (MIRT753765)
- hsa-miR-6721-5p (MIRT753838)
- hsa-miR-6724-5p (MIRT753902)
- hsa-miR-6731-5p (MIRT754040)
- hsa-miR-6754-5p (MIRT754742)
- hsa-miR-6755-5p (MIRT754760)
- hsa-miR-6760-5p (MIRT754946)
- hsa-miR-6762-3p (MIRT754975)
- hsa-miR-6773-5p (MIRT755336)
- hsa-miR-6777-5p (MIRT755396)
- hsa-miR-6778-3p (MIRT755410)
- hsa-miR-6780b-5p (MIRT755653)
- hsa-miR-6781-5p (MIRT755687)
- hsa-miR-6787-5p (MIRT755955)
- hsa-miR-6791-3p (MIRT756037)
- hsa-miR-6794-5p (MIRT756105)
- hsa-miR-6813-5p (MIRT756748)
- hsa-miR-6816-5p (MIRT756816)
- hsa-miR-6820-5p (MIRT756887)
- hsa-miR-6821-5p (MIRT756897)
- hsa-miR-6825-5p (MIRT757019)
- hsa-miR-6828-5p (MIRT757082)
- hsa-miR-6829-3p (MIRT757091)
- hsa-miR-6829-5p (MIRT757115)
- hsa-miR-6836-3p (MIRT757198)
- hsa-miR-6846-3p (MIRT757423)
- hsa-miR-6851-5p (MIRT757619)
- hsa-miR-6853-5p (MIRT757665)
- hsa-miR-6860 (MIRT757864)
- hsa-miR-6870-5p (MIRT758003)
- hsa-miR-6877-5p (MIRT758187)
- hsa-miR-6882-3p (MIRT758362)
- hsa-miR-6884-5p (MIRT758523)
- hsa-miR-6889-5p (MIRT758645)
- hsa-miR-6890-3p (MIRT758652)
- hsa-miR-7111-5p (MIRT759061)
- hsa-miR-7160-5p (MIRT759327)
- hsa-miR-761 (MIRT759477)
- hsa-miR-7851-3p (MIRT759896)
- hsa-miR-8085 (MIRT760244)
- hsa-miR-873-5p (MIRT760326)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC7A5
- Browse OriGene Inhibitory RNA Products For SLC7A5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC7A5
Clone Products
- Applied Biological Materials (abm): Clones for SLC7A5 - Select products 50% OFF >
- * SLC7A5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC7A5
- Addgene plasmids for SLC7A5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC7A5
Cell Line Products
-
Horizon Cell Lines for SLC7A5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A5 Gene
Localization for SLC7A5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC7A5 Gene
- Apical cell membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Lysosome membrane. Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250, ECO:0000269 PubMed:11742812, ECO:0000269 PubMed:25998567, ECO:0000269 PubMed:9751058}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| extracellular | 4 |
| lysosome | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Plasma membrane (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009925 | basal plasma membrane | IEA,ISS | 18619525 |
Pathways & Interactions for SLC7A5 Gene
Pathways by source for SLC7A5 Gene
1 BioSystems pathway for SLC7A5 Gene
11 Reactome pathways for SLC7A5 Gene
2 KEGG pathways for SLC7A5 Gene
2 R&D Systems pathways for SLC7A5 Gene
1 Cell Signaling Technology pathway for SLC7A5 Gene
Interacting Proteins for SLC7A5 Gene
Selected Interacting proteins:
Q01650-LAT1_HUMAN
ENSP00000261622
for SLC7A5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SLC7A5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003333 | amino acid transmembrane transport | IBA | 21873635 |
| GO:0006865 | amino acid transport | IEA | -- |
| GO:0015803 | branched-chain amino acid transport | IEA | -- |
| GO:0015804 | neutral amino acid transport | ISS | -- |
| GO:0015807 | L-amino acid transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC7A5 Gene
Drugs & Compounds for SLC7A5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Melphalan | Approved | Pharma | Transporter | 830 | ||
| Dextrothyroxine | Approved, Investigational | Pharma | Transporter | 0 | ||
| Gabapentin | Approved, Investigational | Pharma | Transporter, substrate | GABA enhancer | 407 | |
| Levodopa | Approved | Pharma | Agonist, Transporter | 470 | ||
| Levothyroxine | Approved | Pharma | Transporter | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sodium |
|
7440-23-5 |
|
Transcripts for SLC7A5 Gene
mRNA/cDNA for SLC7A5 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261622 4556 nts (view in UCSC)
- ENST00000563489 780 nts (view in UCSC)
- ENST00000565644 3983 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC7A5 - Select products 50% OFF >
- * SLC7A5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC7A5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC7A5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC7A5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC7A5
- Browse OriGene Inhibitory RNA Products For SLC7A5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC7A5
Clone Products
- Applied Biological Materials (abm): Clones for SLC7A5 - Select products 50% OFF >
- * SLC7A5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC7A5
- Addgene plasmids for SLC7A5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC7A5
Relevant External Links for SLC7A5 Gene
- GeneLoc Exon Structure for
- SLC7A5
Expression for SLC7A5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Mature brain microvascular endothelial cells (Lippmann ES et. al. 2012)
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Mature brain microvascular endothelial cells (Lippmann ES et. al. 2012)
-
Eye (Sensory Organs)
- Lens Vesicle Cells Lens Vesicle
- Retina
- Lens
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
- Mature Choroid Plexus Cells Choroid Plexus
- Bone (Muscoskeletal System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
- Cartilage (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for SLC7A5 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.1).
This gene is overexpressed in Breast (28.7) and Amniocyte (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC7A5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC7A5
SOURCE GeneReport for Unigene cluster for SLC7A5 Gene:
Hs.513797mRNA Expression by UniProt/SwissProt for SLC7A5 Gene:
Q01650-LAT1_HUMAN
Tissue specificity:
Detected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.
Evidence on tissue expression from TISSUES for SLC7A5 Gene
- Skin(4.7)
- Blood(4.6)
- Intestine(4.5)
- Liver(4.5)
- Nervous system(4.3)
- Pancreas(4)
- Lung(3.5)
- Eye(3.2)
- Lymph node(2.8)
- Spleen(2.8)
- Muscle(2.6)
- Bone marrow(2.6)
- Kidney(2.5)
- Heart(2.5)
- Thyroid gland(2.4)
Primer Products
-
OriGene qPCR primer pairs for SLC7A5
-
OriGene qPCR primer pairs and template standards for SLC7A5
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A5 Gene
Orthologs for SLC7A5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC7A5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LAT 31 |
|
OneToOne | |
| SLC7A5 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | SLC7A5 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC7A5 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc7a5 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc7a5 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC7A5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC7A5 30 31 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc7a5 30 |
|
||
| Str.17935 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68975 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | SLC7A5 31 |
|
OneToOne | |
| LOC797250 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | JhI-21 30 31 32 |
|
ManyToMany | |
| mnd 31 32 |
|
ManyToMany | |||
| CG1607 31 |
|
ManyToMany | |||
| CG6070 32 |
|
|
|||
| gb 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012643 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F27C8.1 32 |
|
|
|
| aat-2 31 |
|
OneToMany | |||
| F52H2.2 32 |
|
|
|||
| F07C3.7 32 |
|
|
|||
| T11F9.4 32 |
|
|
|||
| T13A10.10 32 |
|
|
|||
| Y53H1C.1 32 |
|
|
|||
| C55C2.5a 32 |
|
|
|||
| C55C2.5b 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8408 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5005 30 |
|
- Species where no ortholog for SLC7A5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC7A5 Gene
- ENSEMBL:
- Gene Tree for SLC7A5 (if available)
- TreeFam:
- Gene Tree for SLC7A5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC7A5: view image
Paralogs for SLC7A5 Gene
Paralogs for SLC7A5 Gene
(12) SIMAP similar genes for SLC7A5 Gene using alignment to 2 proteins:
- LAT1_HUMAN
- Q2MCL6_HUMAN
Pseudogenes.org Pseudogenes for SLC7A5 Gene
Variants for SLC7A5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC7A5 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 730064 | Benign: not provided | 87,851,791(-) | G/A | SYNONYMOUS_VARIANT | |
| 731128 | Benign: not provided | 87,869,036(-) | G/A | SYNONYMOUS_VARIANT | |
| 777064 | Benign: not provided | 87,841,152(-) | T/A | MISSENSE_VARIANT | |
| 780313 | Benign: not provided | 87,838,749(-) | G/A | SYNONYMOUS_VARIANT | |
| 780314 | Benign: not provided | 87,841,130(-) | G/C | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3062n100 | CNV | loss | 25217958 |
| dgv36n68 | CNV | loss | 17160897 |
| esv1188587 | CNV | insertion | 17803354 |
| esv24582 | CNV | gain | 19812545 |
| esv2668850 | CNV | deletion | 23128226 |
| esv3553854 | CNV | deletion | 23714750 |
| esv3582432 | CNV | loss | 25503493 |
| esv3639534 | CNV | loss | 21293372 |
| esv3892935 | CNV | loss | 25118596 |
| nsv1059786 | CNV | gain | 25217958 |
| nsv1062946 | CNV | gain | 25217958 |
| nsv1160441 | CNV | deletion | 26073780 |
| nsv457616 | CNV | gain | 19166990 |
| nsv573536 | CNV | gain | 21841781 |
| nsv573557 | CNV | loss | 21841781 |
| nsv833322 | CNV | loss | 17160897 |
| nsv984361 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.51;
43.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC7A5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A5 Gene
Disorders for SLC7A5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| phenylketonuria |
|
|
| lysinuric protein intolerance |
|
|
| maple syrup urine disease |
|
|
| extrahepatic bile duct adenocarcinoma |
|
|
| thymic carcinoma |
|
|
Search SLC7A5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC7A5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A5 Gene
Publications for SLC7A5 Gene
- Functional characterization of tyrosine transport in fibroblast cells from healthy controls. (PMID: 18262359) Vumma R … Venizelos N (Neuroscience letters 2008) 3 4 23
- Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan. (PMID: 17558306) Kühne A … Brockmöller J (Pharmacogenetics and genomics 2007) 3 23 41
- L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. (PMID: 16496379) Nawashiro H … Endou H (International journal of cancer 2006) 3 4 23
- Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols. (PMID: 15769744) Li S … Whorton AR (The Journal of biological chemistry 2005) 3 4 23
- Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea. (PMID: 12824232) Jain-Vakkalagadda B … Mitra AK (Investigative ophthalmology & visual science 2003) 3 4 23
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Sources for SLC7A5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75)