Aliases for SLC7A5 Gene
- Solute Carrier Family 7 Member 5 2 3 4 5
- Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 5 2 3
- Large Neutral Amino Acids Transporter Small Subunit 1 3 4
- L-Type Amino Acid Transporter 1 3 4
- Integral Membrane Protein E16 3 4
- CD98 Light Chain 3 4
- 4F2 Light Chain 3 4
- 4F2LC 3 4
- MPE16 3 4
External Ids for SLC7A5 Gene
Previous GeneCards Identifiers for SLC7A5 Gene
GeneCards Summary for SLC7A5 Gene
SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Lysinuric Protein Intolerance and Phenylketonuria. Among its related pathways are Cell surface interactions at the vascular wall and Basigin interactions. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and antiporter activity. An important paralog of this gene is SLC7A8.
UniProtKB/Swiss-Prot Summary for SLC7A5 Gene
The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).