This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry per... See more...

Aliases for SLC7A11 Gene

Aliases for SLC7A11 Gene

  • Solute Carrier Family 7 Member 11 2 3 4 5
  • XCT 2 3 4
  • Solute Carrier Family 7 (Anionic Amino Acid Transporter Light Chain, Xc- System), Member 11 2 3
  • Calcium Channel Blocker Resistance Protein CCBR1 3 4
  • Amino Acid Transport System Xc- 3 4
  • Cystine/Glutamate Transporter 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 3
  • SLC7A11 5
  • CCBR1 3

External Ids for SLC7A11 Gene

Previous GeneCards Identifiers for SLC7A11 Gene

  • GC04M140018
  • GC04M139368
  • GC04M139551
  • GC04M139662
  • GC04M139669
  • GC04M139442
  • GC04M139304
  • GC04M139085
  • GC04M134820

Summaries for SLC7A11 Gene

Entrez Gene Summary for SLC7A11 Gene

  • This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

GeneCards Summary for SLC7A11 Gene

SLC7A11 (Solute Carrier Family 7 Member 11) is a Protein Coding gene. Diseases associated with SLC7A11 include Kaposi Sarcoma and Cystinuria. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity and cystine:glutamate antiporter activity. An important paralog of this gene is SLC7A5.

UniProtKB/Swiss-Prot Summary for SLC7A11 Gene

  • Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

Gene Wiki entry for SLC7A11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC7A11 Gene

Genomics for SLC7A11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC7A11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J138237 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.3 1314 6.2 ARHGAP35 CEBPG GATAD2A HNRNPL ATF7 PRDM10 ZNF629 TFE3 LEF1 SOX13 SLC7A11 PPP1R14BP3 HSALNG0037363 PCDH18
GH04J138252 Promoter/Enhancer 1 EPDnew Ensembl 600.4 -10.1 -10052 1.2 ZNF512 JUND PKNOX1 DPF2 EP300 CEBPB NFE2 ZNF316 ZNF318 TRIM24 SLC7A11 ENSG00000249091 LINC00498 NOCT
GH04J138404 Enhancer 1.2 FANTOM5 Ensembl ENCODE 42.2 -164.5 -164546 6.2 BACH1 POLR2A TCF12 IKZF2 TRIM22 SOX6 PKNOX1 DPF2 RELB CEBPB lnc-SLC7A11-5 lnc-NOCT-18 SLC7A11 LINC00498 LINC00499 NOCT
GH04J138234 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 26.2 +6.5 6457 3.6 CREB1 ZNF629 ZNF512 IKZF1 JUND RBFOX2 DPF2 HDAC1 SOX6 FOXJ2 HSALNG0037363 SLC7A11 LINC00616 PCDH18
GH04J138305 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 23 -66.3 -66251 8 PRDM10 IKZF2 ETV6 PKNOX1 DPF2 RELB SMARCC1 CEBPB FOS ELK4 LINC00499 SLC7A11 ENSG00000249091 LINC00498 NOCT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC7A11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC7A11

Top Transcription factor binding sites by QIAGEN in the SLC7A11 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • Evi-1
  • Ik-1
  • POU2F1
  • POU2F1a
  • STAT5B

Genomic Locations for SLC7A11 Gene

Genomic Locations for SLC7A11 Gene
chr4:138,164,097-138,242,349
(GRCh38/hg38)
Size:
78,253 bases
Orientation:
Minus strand
chr4:139,085,248-139,163,503
(GRCh37/hg19)
Size:
78,256 bases
Orientation:
Minus strand

Genomic View for SLC7A11 Gene

Genes around SLC7A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A11 Gene

Proteins for SLC7A11 Gene

  • Protein details for SLC7A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY5-XCT_HUMAN
    Recommended name:
    Cystine/glutamate transporter
    Protein Accession:
    Q9UPY5
    Secondary Accessions:
    • A8K2U4

    Protein attributes for SLC7A11 Gene

    Size:
    501 amino acids
    Molecular mass:
    55423 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

neXtProt entry for SLC7A11 Gene

Post-translational modifications for SLC7A11 Gene

  • Glycosylation at Asn314
  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC7A11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A11 Gene

Domains & Families for SLC7A11 Gene

Gene Families for SLC7A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC7A11 Gene

Suggested Antigen Peptide Sequences for SLC7A11 Gene

GenScript: Design optimal peptide antigens:
  • Cystine/glutamate transporter (Q9P1X0_HUMAN)
  • xCT (XCT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UPY5

UniProtKB/Swiss-Prot:

XCT_HUMAN :
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
genes like me logo Genes that share domains with SLC7A11: view

Function for SLC7A11 Gene

Molecular function for SLC7A11 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

Phenotypes From GWAS Catalog for SLC7A11 Gene

Gene Ontology (GO) - Molecular Function for SLC7A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21397861
GO:0015179 L-amino acid transmembrane transporter activity IBA 21873635
GO:0015327 cystine:glutamate antiporter activity TAS 10206947
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC7A11: view
genes like me logo Genes that share phenotypes with SLC7A11: view

Animal Models for SLC7A11 Gene

MGI Knock Outs for SLC7A11:

Animal Model Products

CRISPR Products

miRNA for SLC7A11 Gene

miRTarBase miRNAs that target SLC7A11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC7A11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A11 Gene

Localization for SLC7A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A11 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A11 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 3
endoplasmic reticulum 3
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC7A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0009986 cell surface IDA 25063885
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC7A11: view

Pathways & Interactions for SLC7A11 Gene

genes like me logo Genes that share pathways with SLC7A11: view

Pathways by source for SLC7A11 Gene

1 KEGG pathway for SLC7A11 Gene
1 Cell Signaling Technology pathway for SLC7A11 Gene

Gene Ontology (GO) - Biological Process for SLC7A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA 21873635
GO:0006749 glutathione metabolic process IEA --
GO:0006865 amino acid transport TAS --
GO:0006979 response to oxidative stress IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with SLC7A11: view

No data available for SIGNOR curated interactions for SLC7A11 Gene

Drugs & Compounds for SLC7A11 Gene

(13) Drugs for SLC7A11 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riluzole Approved, Investigational Pharma Activator, Target, inducer, blocker Sodium channel protein inhibitor 76
cystine Approved Nutra Target 0
Sulfasalazine Approved Pharma Inhibitor, Inhibition, Target, inhibitor NF-κB activation inhibitor 84
Glutamic acid Approved Nutra Agonist, Full agonist, Target 304
Acetylcysteine Approved, Investigational Pharma Target, activator Antioxidant;mucolytic agent 427

(3) Additional Compounds for SLC7A11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with SLC7A11: view

Transcripts for SLC7A11 Gene

mRNA/cDNA for SLC7A11 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC7A11

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:

Relevant External Links for SLC7A11 Gene

GeneLoc Exon Structure for
SLC7A11

Expression for SLC7A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC7A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A11 Gene

This gene is overexpressed in Brain - Amygdala (x4.6), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SLC7A11 Gene

This gene is overexpressed in Serum (24.1), Frontal cortex (21.7), Lung (11.9), and Heart (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC7A11 Gene



Protein tissue co-expression partners for SLC7A11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC7A11

SOURCE GeneReport for Unigene cluster for SLC7A11 Gene:

Hs.390594

Evidence on tissue expression from TISSUES for SLC7A11 Gene

  • Kidney(4.4)
  • Nervous system(4.1)
  • Stomach(2.9)
  • Bone(2.6)
  • Blood(2.4)
  • Skin(2.2)
  • Lung(2.1)
  • Eye(2.1)
  • Liver(2.1)
  • Muscle(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with SLC7A11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A11 Gene

Orthologs for SLC7A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC7A11 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC7A11 30 31
  • 93.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A11 31
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC7A11 30 31
  • 88.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc7a11 30
  • 87.93 (n)
Mouse
(Mus musculus)
Mammalia Slc7a11 30 17 31
  • 87.33 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC7A11 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC7A11 30 31
  • 80.25 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC7A11 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496726 30
  • 76.5 (n)
Zebrafish
(Danio rerio)
Actinopterygii CU367845.1 31 31
  • 70 (a)
OneToMany
LOC100331203 30
  • 67.54 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta JhI-21 32
  • 44 (a)
mnd 32
  • 44 (a)
CG6070 32
  • 42 (a)
Worm
(Caenorhabditis elegans)
Secernentea F27C8.1 32
  • 43 (a)
F52H2.2 32
  • 40 (a)
F07C3.7 32
  • 38 (a)
F54D12.3 32
  • 35 (a)
aat-8 31
  • 34 (a)
ManyToMany
aat-7 31
  • 33 (a)
ManyToMany
Y53H1C.1 32
  • 33 (a)
T11F9.4 32
  • 33 (a)
C55C2.5a 32
  • 32 (a)
C55C2.5b 32
  • 32 (a)
T13A10.10 32
  • 31 (a)
aat-6 31
  • 30 (a)
ManyToMany
aat-4 31
  • 30 (a)
ManyToMany
F28F9.4 32
  • 30 (a)
aat-9 31
  • 29 (a)
ManyToMany
aat-5 31
  • 28 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MUP1 31
  • 20 (a)
ManyToMany
MUP3 31
  • 19 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.198 31
  • 38 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Species where no ortholog for SLC7A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC7A11 Gene

ENSEMBL:
Gene Tree for SLC7A11 (if available)
TreeFam:
Gene Tree for SLC7A11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC7A11: view image

Paralogs for SLC7A11 Gene

(9) SIMAP similar genes for SLC7A11 Gene using alignment to 3 proteins:

  • XCT_HUMAN
  • H0Y9F9_HUMAN
  • Q4W5A5_HUMAN
genes like me logo Genes that share paralogs with SLC7A11: view

Variants for SLC7A11 Gene

Additional dbSNP identifiers (rs#s) for SLC7A11 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC7A11 Gene

Variant ID Type Subtype PubMed ID
esv2759286 CNV loss 17122850
nsv470081 CNV loss 18288195
nsv470082 CNV gain 18288195
nsv508317 CNV deletion 20534489
nsv526177 CNV loss 19592680
nsv818280 CNV gain 17921354
nsv822746 CNV loss 20364138
nsv830080 CNV gain 17160897

Variation tolerance for SLC7A11 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC7A11 Gene

Human Gene Mutation Database (HGMD)
SLC7A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC7A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC7A11 Gene

Disorders for SLC7A11 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SLC7A11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
cystinuria
  • csnu
lysinuric protein intolerance
  • lpi
thyrotoxic exophthalmos
occlusion of gallbladder
  • obstruction of gallbladder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC7A11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLC7A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A11 Gene

Publications for SLC7A11 Gene

  1. Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. (PMID: 12763038) Wang H … Sato H (Biochemical and biophysical research communications 2003) 2 3 23
  2. Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. (PMID: 11133847) Bridges CC … Ganapathy V (Investigative ophthalmology & visual science 2001) 3 4 23
  3. Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. (PMID: 11213471) Sato H … Bannai S (Antioxidants & redox signaling 2000) 3 4 23
  4. Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. (PMID: 20007406) Pham AN … Huang Y (The Journal of pharmacology and experimental therapeutics 2010) 3 23
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41

Products for SLC7A11 Gene

  • Biorbyt antibodies for SLC7A11
  • Signalway ELISA kits for SLC7A11
  • Signalway Proteins for SLC7A11

Sources for SLC7A11 Gene