Aliases for SLC6A4 Gene
- Solute Carrier Family 6 Member 4 2 3 4 5
- Solute Carrier Family 6 (Neurotransmitter Transporter, Serotonin), Member 4 2 3
- Solute Carrier Family 6 (Neurotransmitter Transporter), Member 4 2 3
- 5-Hydroxytryptamine (Serotonin) Transporter 2 3
- Sodium-Dependent Serotonin Transporter 3 4
- Serotonin Transporter 1 2 3
- 5HT Transporter 3 4
- 5-HTT 2 3
- SERT1 2 3
External Ids for SLC6A4 Gene
Previous HGNC Symbols for SLC6A4 Gene
Previous GeneCards Identifiers for SLC6A4 Gene
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
GeneCards Summary for SLC6A4 Gene
SLC6A4 (Solute Carrier Family 6 Member 4) is a Protein Coding gene. Diseases associated with SLC6A4 include Obsessive-Compulsive Disorder and Anxiety. Among its related pathways are Monoamine Transport and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is SLC6A3.
UniProtKB/Swiss-Prot Summary for SLC6A4 Gene
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move molecules.