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Aliases for SLC6A16 Gene

Aliases for SLC6A16 Gene

  • Solute Carrier Family 6 Member 16 2 3 4 5
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 16 2 3
  • NTT5 3 4
  • Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT5 3
  • Solute Carrier Family 6, Member 16 2
  • NTT5 Protein 2
  • CTC-301O7.4 3
  • NT5 3

External Ids for SLC6A16 Gene

Previous GeneCards Identifiers for SLC6A16 Gene

  • GC00U990833
  • GC19M054484
  • GC19M049792
  • GC19M046169

Summaries for SLC6A16 Gene

Entrez Gene Summary for SLC6A16 Gene

  • SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC6A16 Gene

SLC6A16 (Solute Carrier Family 6 Member 16) is a Protein Coding gene. Diseases associated with SLC6A16 include Retinitis Pigmentosa 11. Among its related pathways are NRF2 pathway. Gene Ontology (GO) annotations related to this gene include neurotransmitter:sodium symporter activity and neurotransmitter transporter activity. An important paralog of this gene is SLC6A17.

Additional gene information for SLC6A16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A16 Gene

Genomics for SLC6A16 Gene

GeneHancer (GH) Regulatory Elements for SLC6A16 Gene

Promoters and enhancers for SLC6A16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049326 Promoter/Enhancer 1 EPDnew dbSUPER 550.4 +6.5 6490 0.1 KLF1 ZBTB33 MLLT1 MGA SLC6A16 MIR4324
GH19I049318 Promoter 0.7 EPDnew 550.4 +13.0 12972 0.1 ZNF26 SETDB1 SLC6A16 ADM5 PIH1D1 IRF3 GRWD1 SNORD35A SNORD35B PRR12 MIR4324
GH19I048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +367.7 367672 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PTOV1-AS2 IRF3 PRR12 SNORD35A SNORD35B
GH19I049486 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.2 -158.5 -158539 7.5 ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 SNORD35A RPL13A GC19P049514 GC19P049531 GC19P049554 GC19P049556 GC19P049559 GC19P049561 PIR54526 PIR58998
GH19I049589 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -260.3 -260342 5.8 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 PRR12 NOSIP PIR34329 NUP62 POLD1 IRF3 ENSG00000268047 ALDH16A1 SNORD35A SNORD35B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC6A16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC6A16 gene promoter:

Genomic Locations for SLC6A16 Gene

Genomic Locations for SLC6A16 Gene
42,070 bases
Minus strand

Genomic View for SLC6A16 Gene

Genes around SLC6A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC6A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC6A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A16 Gene

Proteins for SLC6A16 Gene

  • Protein details for SLC6A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
    Protein Accession:
    Secondary Accessions:
    • Q8IYV4
    • Q9Y5I9

    Protein attributes for SLC6A16 Gene

    736 amino acids
    Molecular mass:
    82200 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A16 Gene


neXtProt entry for SLC6A16 Gene

Post-translational modifications for SLC6A16 Gene

No data available for DME Specific Peptides for SLC6A16 Gene

Domains & Families for SLC6A16 Gene

Gene Families for SLC6A16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC6A16 Gene


Suggested Antigen Peptide Sequences for SLC6A16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.
genes like me logo Genes that share domains with SLC6A16: view

Function for SLC6A16 Gene

Phenotypes From GWAS Catalog for SLC6A16 Gene

Gene Ontology (GO) - Molecular Function for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005326 neurotransmitter transporter activity NAS 11112352
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC6A16: view
genes like me logo Genes that share phenotypes with SLC6A16: view

miRNA for SLC6A16 Gene

miRTarBase miRNAs that target SLC6A16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC6A16 Gene

Localization for SLC6A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC6A16 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11112352
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

Pathways & Interactions for SLC6A16 Gene

SuperPathways for SLC6A16 Gene

SuperPathway Contained pathways
1 NRF2 pathway
genes like me logo Genes that share pathways with SLC6A16: view

Pathways by source for SLC6A16 Gene

1 BioSystems pathway for SLC6A16 Gene

Interacting Proteins for SLC6A16 Gene

Gene Ontology (GO) - Biological Process for SLC6A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA,NAS 11112352
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC6A16: view

No data available for SIGNOR curated interactions for SLC6A16 Gene

Drugs & Compounds for SLC6A16 Gene

(1) Additional Compounds for SLC6A16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC6A16: view

Transcripts for SLC6A16 Gene

Unigene Clusters for SLC6A16 Gene

Solute carrier family 6, member 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP4: - -

Relevant External Links for SLC6A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC6A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A16 Gene

This gene is overexpressed in Testis (x16.1).

Protein differential expression in normal tissues from HIPED for SLC6A16 Gene

This gene is overexpressed in Testis (39.0) and Spleen (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC6A16 Gene

Protein tissue co-expression partners for SLC6A16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC6A16 Gene:


SOURCE GeneReport for Unigene cluster for SLC6A16 Gene:


mRNA Expression by UniProt/SwissProt for SLC6A16 Gene:

Tissue specificity: Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.
genes like me logo Genes that share expression patterns with SLC6A16: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC6A16 Gene

Orthologs for SLC6A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC6A16 33 34
  • 99.23 (n)
(Canis familiaris)
Mammalia SLC6A16 33 34
  • 77.28 (n)
(Bos Taurus)
Mammalia SLC6A16 33 34
  • 75.08 (n)
(Mus musculus)
Mammalia Slc6a16 33 16 34
  • 67.09 (n)
(Rattus norvegicus)
Mammalia Slc6a16 33
  • 67 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
-- 34
  • 36 (a)
(Monodelphis domestica)
Mammalia SLC6A16 34
  • 34 (a)
(Anolis carolinensis)
Reptilia SLC6A16 34
  • 36 (a)
(Danio rerio)
Actinopterygii SLC6A16 (2 of 2) 34
  • 34 (a)
SLC6A16 (1 of 2) 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43066 34
  • 27 (a)
CG10804 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3644 34
  • 33 (a)
-- 34
  • 30 (a)
Species where no ortholog for SLC6A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC6A16 Gene

Gene Tree for SLC6A16 (if available)
Gene Tree for SLC6A16 (if available)

Paralogs for SLC6A16 Gene

Paralogs for SLC6A16 Gene

genes like me logo Genes that share paralogs with SLC6A16: view

Variants for SLC6A16 Gene

Sequence variations from dbSNP and Humsavar for SLC6A16 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000045942 -- 49,331,368(-) G/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000065054 -- 49,324,608(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000285092 -- 49,289,551(-) A/G downstream_transcript_variant
rs1000305843 -- 49,296,350(-) A/G intron_variant
rs1000362798 -- 49,304,699(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A16 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV gain+loss 18304495
nsv474708 CNV novel sequence insertion 20440878
esv3644621 CNV loss 21293372
esv3644620 CNV loss 21293372
esv3348764 CNV insertion 20981092
esv2658176 CNV deletion 23128226
dgv52n68 CNV loss 17160897

Variation tolerance for SLC6A16 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC6A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A16 Gene

Disorders for SLC6A16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC6A16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC6A16

genes like me logo Genes that share disorders with SLC6A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC6A16 Gene

Publications for SLC6A16 Gene

  1. Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family. (PMID: 11112352) Farmer MK … Pangalos MN (Genomics 2000) 2 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  3. Neurotransmitter transporters in the central nervous system. (PMID: 10471414) Masson J … El Mestikawy S (Pharmacological reviews 1999) 2 3 58
  4. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for SLC6A16 Gene

Sources for SLC6A16 Gene

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