Aliases for SLC66A1L Gene

Aliases for SLC66A1L Gene

  • Solute Carrier Family 66 Member 1 Like 2 3 5
  • Putative Uncharacterized Protein SLC66A1L 3 4
  • PQ-Loop Repeat-Containing Protein 2-Like 3 4
  • PQ Loop Repeat Containing 2 Like 2 3
  • C3orf55 3 4
  • PQLC2L 3 4
  • Solute Carrier Family 66 Member 1-Like 4
  • Chromosome 3 Open Reading Frame 55 2
  • SLC66A2L 3

External Ids for SLC66A1L Gene

Previous HGNC Symbols for SLC66A1L Gene

  • C3orf55
  • PQLC2L

Summaries for SLC66A1L Gene

GeneCards Summary for SLC66A1L Gene

SLC66A1L (Solute Carrier Family 66 Member 1 Like) is a Protein Coding gene. An important paralog of this gene is SLC66A1.

Additional gene information for SLC66A1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC66A1L Gene

Genomics for SLC66A1L Gene

GeneHancer (GH) Regulatory Elements for SLC66A1L Gene

Promoters and enhancers for SLC66A1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J157542 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 514.4 +0.1 55 1.4 CTCF HDAC2 MXI1 MYC YY1 USF1 POLR2A RAD21 CTBP2 ZNF143 SLC66A1L NONHSAG036498.2 VEPH1
GH03J157512 Promoter 1 EPDnew 500.3 -30.6 -30589 0.1 TOE1 CTBP1 MYC FOSL1 NCOR1 MAX ATF3 EHMT2 TAL1 HDAC2 SLC66A1L lnc-CCNL1-8 VEPH1
GH03J157544 Enhancer 0.4 ENCODE 500.7 +1.5 1494 0.6 NFE2 MAFG NFE2L2 NONHSAG036498.2 SLC66A1L piR-56133-152
GH03J157530 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.9 -11.0 -10966 4.3 ZNF217 CTCF FOS ZBTB11 REST RAD21 TRIM22 SMC3 NFRKB ZNF316 VEPH1 SLC66A1L lnc-CCNL1-8
GH03J157502 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 -39.7 -39677 2.3 NR3C1 PBX2 JUND GATA3 PKNOX1 ESR1 GATA2 VEPH1 SLC66A1L lnc-CCNL1-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC66A1L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC66A1L

Genomic Locations for SLC66A1L Gene

Genomic Locations for SLC66A1L Gene
chr3:157,543,246-157,677,750
(GRCh38/hg38)
Size:
134,505 bases
Orientation:
Plus strand
chr3:157,261,035-157,395,538
(GRCh37/hg19)
Size:
134,504 bases
Orientation:
Plus strand

Genomic View for SLC66A1L Gene

Genes around SLC66A1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC66A1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC66A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC66A1L Gene

Proteins for SLC66A1L Gene

  • Protein details for SLC66A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4F0-S66AL_HUMAN
    Recommended name:
    Putative uncharacterized protein SLC66A1L
    Protein Accession:
    A1A4F0
    Secondary Accessions:
    • C9JP04
    • C9JXB5
    • Q8N6Q6

    Protein attributes for SLC66A1L Gene

    Size:
    135 amino acids
    Molecular mass:
    15626 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29129.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC66A1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC66A1L Gene

Post-translational modifications for SLC66A1L Gene

No Post-translational modifications

Other Protein References for SLC66A1L Gene

No data available for DME Specific Peptides for SLC66A1L Gene

Domains & Families for SLC66A1L Gene

Gene Families for SLC66A1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SLC66A1L Gene

ProtoNet:
genes like me logo Genes that share domains with SLC66A1L: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SLC66A1L Gene

Function for SLC66A1L Gene

Phenotypes From GWAS Catalog for SLC66A1L Gene

Gene Ontology (GO) - Molecular Function for SLC66A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015174 basic amino acid transmembrane transporter activity IBA 21873635
GO:0015181 arginine transmembrane transporter activity IBA 21873635
GO:0015189 L-lysine transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC66A1L: view
genes like me logo Genes that share phenotypes with SLC66A1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC66A1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC66A1L Gene

Localization for SLC66A1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC66A1L gene
Compartment Confidence
lysosome 3
extracellular 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC66A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC66A1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SLC66A1L Gene

Pathways & Interactions for SLC66A1L Gene

PathCards logo

SuperPathways for SLC66A1L Gene

No Data Available

Interacting Proteins for SLC66A1L Gene

;

Gene Ontology (GO) - Biological Process for SLC66A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903401 L-lysine transmembrane transport IEA --
GO:1903826 arginine transmembrane transport IEA --
GO:1990822 basic amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC66A1L: view

No data available for Pathways by source and SIGNOR curated interactions for SLC66A1L Gene

Drugs & Compounds for SLC66A1L Gene

No Compound Related Data Available

Transcripts for SLC66A1L Gene

mRNA/cDNA for SLC66A1L Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC66A1L

Alternative Splicing Database (ASD) splice patterns (SP) for SLC66A1L Gene

No ASD Table

Relevant External Links for SLC66A1L Gene

GeneLoc Exon Structure for
SLC66A1L

Expression for SLC66A1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC66A1L

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC66A1L Gene

Orthologs for SLC66A1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC66A1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf55 31
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf55 31
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3orf55 31
  • 7 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
OneToMany
-- 31
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea laat-1 31
  • 10 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTC2 31
  • 9 (a)
ManyToMany
-- 31
  • 9 (a)
ManyToMany
-- 31
  • 8 (a)
ManyToMany
Species where no ortholog for SLC66A1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC66A1L Gene

ENSEMBL:
Gene Tree for SLC66A1L (if available)
TreeFam:
Gene Tree for SLC66A1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC66A1L: view image

Paralogs for SLC66A1L Gene

Paralogs for SLC66A1L Gene

genes like me logo Genes that share paralogs with SLC66A1L: view

Variants for SLC66A1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC66A1L Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs7616293 - p.Val4Leu

Additional dbSNP identifiers (rs#s) for SLC66A1L Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC66A1L Gene

Variant ID Type Subtype PubMed ID
esv2726098 CNV deletion 23290073
nsv4081 CNV deletion 18451855
nsv829767 CNV loss 17160897

Variation tolerance for SLC66A1L Gene

Gene Damage Index Score: 0.69; 14.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC66A1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC66A1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC66A1L Gene

Disorders for SLC66A1L Gene

No disorders were found for SLC66A1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SLC66A1L Gene

Publications for SLC66A1L Gene

  1. Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking. (PMID: 22363504) Saudek V (PloS one 2012) 2 3 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for SLC66A1L Gene

Sources for SLC66A1L Gene