Aliases for SLC5A5 Gene
External Ids for SLC5A5 Gene
Previous GeneCards Identifiers for SLC5A5 Gene
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
GeneCards Summary for SLC5A5 Gene
SLC5A5 (Solute Carrier Family 5 Member 5) is a Protein Coding gene. Diseases associated with SLC5A5 include Thyroid Dyshormonogenesis 1 and Familial Thyroid Dyshormonogenesis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include transporter activity and iodide transmembrane transporter activity. An important paralog of this gene is SLC5A8.
UniProtKB/Swiss-Prot Summary for SLC5A5 Gene
Mediates iodide uptake in the thyroid gland.