Aliases for SLC5A12 Gene
- Solute Carrier Family 5 Member 12 2 3 4 5
- Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter), Member 12 2 3
- Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 12 2 3
- Electroneutral Sodium Monocarboxylate Cotransporter 3 4
- Sodium-Coupled Monocarboxylate Transporter 2 3 4
- Low-Affinity Sodium-Lactate Cotransporter 3 4
- SMCT2 3 4
- Sodium-Iodide Related Cotransporter 3
External Ids for SLC5A12 Gene
Previous GeneCards Identifiers for SLC5A12 Gene
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]
GeneCards Summary for SLC5A12 Gene
SLC5A12 (Solute Carrier Family 5 Member 12) is a Protein Coding gene. Among its related pathways are NRF2 pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC5A8.
UniProtKB/Swiss-Prot Summary for SLC5A12 Gene
Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).