Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008] See more...

Aliases for SLC5A11 Gene

Aliases for SLC5A11 Gene

  • Solute Carrier Family 5 Member 11 2 3 4 5
  • Solute Carrier Family 5 (Sodium/Inositol Cotransporter), Member 11 2 3
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 11 2 3
  • Sodium-Dependent Glucose Cotransporter 3 4
  • Sodium/Myo-Inositol Cotransporter 2 3 4
  • Na(+)/Myo-Inositol Cotransporter 2 3 4
  • Sodium/Glucose Cotransporter KST1 3 4
  • Sodium/Myo-Inositol Transporter 2 3 4
  • SMIT2 3 4
  • KST1 3 4
  • Putative Sodium-Coupled Cotransporter RKST1 3
  • Homolog Of Rabbit KST1 3
  • RKST1 3
  • SGLT6 3
  • SLGTX 4

External Ids for SLC5A11 Gene

Previous GeneCards Identifiers for SLC5A11 Gene

  • GC16P024825
  • GC16P024765
  • GC16P022948

Summaries for SLC5A11 Gene

Entrez Gene Summary for SLC5A11 Gene

  • Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC5A11 Gene

SLC5A11 (Solute Carrier Family 5 Member 11) is a Protein Coding gene. Diseases associated with SLC5A11 include Systemic Lupus Erythematosus and Benign Familial Infantile Epilepsy. Among its related pathways are NRF2 pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC5A1.

UniProtKB/Swiss-Prot Summary for SLC5A11 Gene

  • Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

Additional gene information for SLC5A11 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC5A11 Gene

Genomics for SLC5A11 Gene

GeneHancer (GH) Regulatory Elements for SLC5A11 Gene

Promoters and enhancers for SLC5A11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J024844 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 535.5 -1.2 -1205 1.3 TCF12 JUND FOS PHB2 AFF1 TARDBP REST TOE1 MYC CTBP1 SLC5A11 lnc-TNRC6A-2 piR-50437-245
GH16J024845 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 535.5 +1.5 1542 4.1 FOXK2 TCF12 POLR2G NCOR1 JUND REST HES1 ZBTB25 U2AF2 RBM25 SLC5A11 lnc-TNRC6A-2 ENSG00000261669 piR-57133-228
GH16J024775 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 54.4 -69.4 -69418 3.6 ZNF316 MAFF MAFK RBM22 JUND GATA3 FOXA1 MAFG ZBTB40 HNF4A lnc-ARHGAP17-11 TNRC6A SLC5A11 RF00017-2021
GH16J024728 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.2 -115.2 -115196 4.1 ZBTB40 ZNF217 EP300 TCF12 POLR2G SP1 PHF8 SIX5 ZFX ZNF639 SLC5A11 RBBP6 SCML2P2 RF00017-2021 lnc-ARHGAP17-11 TNRC6A
GH16J024736 Enhancer 1 ENCODE dbSUPER 52.7 -108.4 -108419 2.2 JUND FOS TCF7 MYC TEAD1 CREB1 FOXA2 ZNF316 NFIC MAFF SLC5A11 RF00017-2021 lnc-ARHGAP17-11 TNRC6A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC5A11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC5A11

Top Transcription factor binding sites by QIAGEN in the SLC5A11 gene promoter:
  • AREB6
  • GATA-1
  • Hlf
  • HNF-1
  • HNF-1A
  • HOXA3
  • Nkx6-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SLC5A11 Gene

Genomic Locations for SLC5A11 Gene
chr16:24,845,841-24,911,628
(GRCh38/hg38)
Size:
65,788 bases
Orientation:
Plus strand
chr16:24,857,162-24,922,949
(GRCh37/hg19)
Size:
65,788 bases
Orientation:
Plus strand

Genomic View for SLC5A11 Gene

Genes around SLC5A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A11 Gene

Proteins for SLC5A11 Gene

  • Protein details for SLC5A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWX8-SC5AB_HUMAN
    Recommended name:
    Sodium/myo-inositol cotransporter 2
    Protein Accession:
    Q8WWX8
    Secondary Accessions:
    • B7Z329
    • Q05BF1
    • Q6PF02
    • Q6ZUW3
    • Q86Y55
    • Q96PP5

    Protein attributes for SLC5A11 Gene

    Size:
    675 amino acids
    Molecular mass:
    74036 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Acts as an autoimmune modifier in systemic lupus erythematosus (SLE) as it is significantly associated with low complement component 4 (C4), anti-Smith antibody, serositis, and alopecia.

    Alternative splice isoforms for SLC5A11 Gene

neXtProt entry for SLC5A11 Gene

Post-translational modifications for SLC5A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC5A11 Gene

Domains & Families for SLC5A11 Gene

Gene Families for SLC5A11 Gene

Protein Domains for SLC5A11 Gene

Blocks:
  • Na+/solute symporter
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC5A11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50153, highly similar to Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 11 (SLC5A11), mRNA (B7Z329_HUMAN)
  • Solute carrier family 5 member 11 (SC5AB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWX8

UniProtKB/Swiss-Prot:

SC5AB_HUMAN :
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A11: view

Function for SLC5A11 Gene

Molecular function for SLC5A11 Gene

UniProtKB/Swiss-Prot Function:
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

Phenotypes From GWAS Catalog for SLC5A11 Gene

Gene Ontology (GO) - Molecular Function for SLC5A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005412 glucose:sodium symporter activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0015166 polyol transmembrane transporter activity TAS --
GO:0015293 symporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A11: view
genes like me logo Genes that share phenotypes with SLC5A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC5A11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC5A11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC5A11 Gene

Localization for SLC5A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC5A11 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC5A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC5A11: view

Pathways & Interactions for SLC5A11 Gene

PathCards logo

SuperPathways for SLC5A11 Gene