Aliases for SLC5A11 Gene
- Solute Carrier Family 5 Member 11 2 3 4 5
- SMIT2 2 3 4
- KST1 2 3 4
- Solute Carrier Family 5 (Sodium/Inositol Cotransporter), Member 11 2 3
- Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 11 2 3
- Sodium-Dependent Glucose Cotransporter 3 4
- Sodium/Myo-Inositol Cotransporter 2 3 4
- Na(+)/Myo-Inositol Cotransporter 2 3 4
External Ids for SLC5A11 Gene
Previous GeneCards Identifiers for SLC5A11 Gene
Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC5A11 Gene
SLC5A11 (Solute Carrier Family 5 Member 11) is a Protein Coding gene. Diseases associated with SLC5A11 include Systemic Lupus Erythematosus and Benign Familial Infantile Epilepsy. Among its related pathways are NRF2 pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC5A1.
UniProtKB/Swiss-Prot Summary for SLC5A11 Gene
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.