SLC5A10 Gene (Protein Coding)

Solute Carrier Family 5 Member 10

GC17P018950
GIFtS:
37
This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has t... See more...

Aliases for SLC5A10 Gene

Aliases for SLC5A10 Gene

  • Solute Carrier Family 5 Member 10 2 3 4 5
  • Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 10 2 3
  • Solute Carrier Family 5 (Sodium/Sugar Cotransporter), Member 10 2 3
  • Sodium/Glucose Cotransporter 5 3 4
  • Na(+)/Glucose Cotransporter 5 3 4
  • SGLT5 3 4
  • SGLT-5 3

External Ids for SLC5A10 Gene

Previous GeneCards Identifiers for SLC5A10 Gene

  • GC17P019062
  • GC17P019054
  • GC17P018794
  • GC17P018796
  • GC17P018853
  • GC17P018422

Summaries for SLC5A10 Gene

Entrez Gene Summary for SLC5A10 Gene

  • This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for SLC5A10 Gene

SLC5A10 (Solute Carrier Family 5 Member 10) is a Protein Coding gene. Among its related pathways are Hexose transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC5A9.

UniProtKB/Swiss-Prot Summary for SLC5A10 Gene

  • High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.

Additional gene information for SLC5A10 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC5A10 Gene

Genomics for SLC5A10 Gene

GeneHancer (GH) Regulatory Elements for SLC5A10 Gene

Promoters and enhancers for SLC5A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J018949 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 750.6 +0.2 156 2.2 AHR CBFA2T2 PKNOX1 SP1 NFIL3 CBFA2T3 MIER2 SLC5A10 piR-56801 PRPSAP2 LOC100419436
GH17J018951 Enhancer 0.7 Ensembl dbSUPER 750.6 +1.6 1556 0.2 CTCF ZNF644 RXRB RAD21 PRDM10 THRB TEAD3 NR2F6 SLC5A10 piR-56801 ENSG00000196893
GH17J018952 Promoter 0.7 EPDnew 755.6 +1.8 1801 0.1 ZNF644 RXRB CTCF THRB TEAD3 NR2F6 SLC5A10 piR-56801 ENSG00000196893
GH17J018919 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.5 -27.1 -27144 7.6 SIN3A SP1 RBPJ NR2F1 NR2F6 MIXL1 ETV6 HLF NKRF ELF3 PRPSAP2 DRG2 SMCR8 ENSG00000212618 SLC5A10 ENSG00000196893 ENSG00000262202 MAPK7 ENSG00000264932 FOXO3B
GH17J019235 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.3 +287.2 287156 4.6 ZNF785 L3MBTL2 MNT POLR2A NKRF SP7 ZNF687 IKZF1 GLIS2 ZIC2 EPN2 EPN2-IT1 ENSG00000228157 ENSG00000262319 MIR1180 SLC47A1 SNORA59B ENSG00000230197 SLC5A10 RNF112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC5A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC5A10 gene promoter:
  • AREB6
  • COMP1
  • HEN1
  • HNF-1
  • HNF-1A
  • LyF-1
  • POU2F1
  • POU2F1a

Genomic Locations for SLC5A10 Gene

Genomic Locations for SLC5A10 Gene
chr17:18,950,345-19,022,595
(GRCh38/hg38)
Size:
72,251 bases
Orientation:
Plus strand
chr17:18,853,658-18,925,908
(GRCh37/hg19)
Size:
72,251 bases
Orientation:
Plus strand

Genomic View for SLC5A10 Gene

Genes around SLC5A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC5A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC5A10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC5A10 Gene

Proteins for SLC5A10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SLC5A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJK1-SC5AA_HUMAN
    Recommended name:
    Sodium/glucose cotransporter 5
    Protein Accession:
    A0PJK1
    Secondary Accessions:
    • A8MUC9
    • B4DPI0
    • B7WPR4
    • Q6P5X0
    • Q8IXM4
    • Q96LQ1

    Protein attributes for SLC5A10 Gene

    Size:
    596 amino acids
    Molecular mass:
    64342 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71619.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC5A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC5A10 Gene

Protein Expression for SLC5A10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC5A10 Gene

  • Glycosylation at Asn4 and Asn96
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC5A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC5A10 Gene

Domains & Families for SLC5A10 Gene

Gene Families for SLC5A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC5A10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC5A10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60765, highly similar to Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 10, transcript variant 2, mRNA (B4DPI0_HUMAN)
  • Solute carrier family 5 member 10 (SC5AA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A0PJK1

UniProtKB/Swiss-Prot:

SC5AA_HUMAN :
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Family:
  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
genes like me logo Genes that share domains with SLC5A10: view

Function for SLC5A10 Gene

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  2. CRISPR
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Molecular function for SLC5A10 Gene

UniProtKB/Swiss-Prot Function:
High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.

Phenotypes From GWAS Catalog for SLC5A10 Gene

Gene Ontology (GO) - Molecular Function for SLC5A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005412 glucose:sodium symporter activity IBA 21873635
GO:0015370 solute:sodium symporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC5A10: view
genes like me logo Genes that share phenotypes with SLC5A10: view

Animal Models for SLC5A10 Gene

MGI Knock Outs for SLC5A10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC5A10

CRISPR Products

miRNA for SLC5A10 Gene

miRTarBase miRNAs that target SLC5A10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC5A10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC5A10 Gene

Localization for SLC5A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC5A10 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC5A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SLC5A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC5A10 Gene

Pathways & Interactions for SLC5A10 Gene

genes like me logo Genes that share pathways with SLC5A10: view

Pathways by source for SLC5A10 Gene

1 BioSystems pathway for SLC5A10 Gene

Interacting Proteins for SLC5A10 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000379008 A0PJK1-SC5AA_HUMAN for SLC5A10 Gene via STRING IID

GPS-Prot Interaction Network for SLC5A10

Gene Ontology (GO) - Biological Process for SLC5A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0008645 hexose transmembrane transport TAS --
GO:0035725 sodium ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC5A10: view

No data available for SIGNOR curated interactions for SLC5A10 Gene

Drugs & Compounds for SLC5A10 Gene

Products:

  1. Drug

(1) Drugs for SLC5A10 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Empagliflozin (BI 10773) Pharma SGLT-2 inhibitor for oral treatment of type 2 diabetes 0

(1) Additional Compounds for SLC5A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
 7440-23-5

(1) ApexBio Compounds for SLC5A10 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
genes like me logo Genes that share compounds with SLC5A10: view

Drug Products

Transcripts for SLC5A10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SLC5A10 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC5A10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A10 Gene

No ASD Table

Relevant External Links for SLC5A10 Gene

GeneLoc Exon Structure for
SLC5A10
ECgene alternative splicing isoforms for
SLC5A10

Expression for SLC5A10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC5A10 Gene

mRNA expression in normal human tissues for SLC5A10 Gene
mRNA expression by GTEx for SLC5A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC5A10 Gene

This gene is overexpressed in Kidney - Cortex (x46.2).

Protein differential expression in normal tissues from HIPED for SLC5A10 Gene

This gene is overexpressed in Urine (61.7) and Kidney (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC5A10 Gene



Protein tissue co-expression partners for SLC5A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC5A10 Gene:

SLC5A10

SOURCE GeneReport for Unigene cluster for SLC5A10 Gene:

Hs.462418

mRNA Expression by UniProt/SwissProt for SLC5A10 Gene:

A0PJK1-SC5AA_HUMAN
Tissue specificity: Seems to be exclusively expressed in kidney.

Evidence on tissue expression from TISSUES for SLC5A10 Gene

  • Kidney(4.5)
  • Intestine(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC5A10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC5A10 Gene

Orthologs for SLC5A10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SLC5A10 33
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia SLC5A10 33 32
  • 87.52 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia SLC5A10 33 32
  • 87.45 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Slc5a10 17 33 32
  • 84.06 (n)
rat
(Rattus norvegicus)
 Mammalia Slc5a10 32
  • 83.45 (n)
oppossum
(Monodelphis domestica)
 Mammalia SLC5A10 33
  • 81 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 76 (a)
 OneToMany
-- 33
  • 67 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves SLC5A10 33 32
  • 74.16 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SLC5A10 33
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia slc5a10 32
  • 70.13 (n)
zebrafish
(Danio rerio)
 Actinopterygii si:dkeyp-9d4.5 32
  • 68.62 (n)
SLC5A10 33
  • 65 (a)
 OneToOne
Species where no ortholog for SLC5A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A10 Gene

ENSEMBL:
Gene Tree for SLC5A10 (if available)
TreeFam:
Gene Tree for SLC5A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC5A10: view image

Paralogs for SLC5A10 Gene

Paralogs for SLC5A10 Gene

(6) SIMAP similar genes for SLC5A10 Gene using alignment to 1 proteins:

  • SC5AA_HUMAN
genes like me logo Genes that share paralogs with SLC5A10: view

Variants for SLC5A10 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SLC5A10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000017554 -- 18,979,406(+) GGG/GG intron_variant
rs1000040617 -- 19,013,460(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs1000108166 -- 19,005,577(+) G/C intron_variant
rs1000119288 -- 18,982,264(+) C/G intron_variant
rs1000156355 -- 18,968,490(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC5A10 Gene

Variant ID Type Subtype PubMed ID
dgv3116n100 CNV gain 25217958
dgv5491n54 CNV gain 21841781
dgv565e214 CNV gain 21293372
dgv895e212 CNV loss 25503493
esv1783904 CNV insertion 17803354
esv2758678 CNV gain+loss 17122850
esv3310541 CNV novel sequence insertion 20981092
esv33572 CNV gain 17666407
esv3424584 CNV duplication 20981092
esv3572465 CNV gain 25503493
esv3892975 CNV loss 25118596
nsv1055999 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv428336 CNV gain+loss 18775914
nsv457699 CNV gain 19166990
nsv470581 CNV gain 18288195
nsv474110 CNV novel sequence insertion 20440878
nsv479430 CNV novel sequence insertion 20440878
nsv523721 CNV gain 19592680
nsv574552 CNV gain 21841781
nsv7291 OTHER inversion 18451855
nsv833390 CNV loss 17160897
nsv833391 CNV loss 17160897
nsv9504 CNV gain+loss 18304495
nsv953842 CNV deletion 24416366

Variation tolerance for SLC5A10 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC5A10 Gene

Human Gene Mutation Database (HGMD)
SLC5A10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC5A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A10 Gene

Disorders for SLC5A10 Gene

Additional Disease Information for SLC5A10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC5A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC5A10 Gene

Publications for SLC5A10 Gene

  1. Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter. (PMID: 22212718) Grempler R … Eickelmann P (FEBS letters 2012) 3 4 56
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  3. Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer. (PMID: 30281872) Hong MJ … Park JY (Cancer science 2018) 3 56
  4. Fingerprints of hSGLT5 sugar and cation selectivity. (PMID: 24573086) Ghezzi C … Wright EM (American journal of physiology. Cell physiology 2014) 3 56
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 56

ExternalLinks

View latest publications for SLC5A10 gene in Mastermind

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