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This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
SLC5A10 (Solute Carrier Family 5 Member 10) is a Protein Coding gene. Among its related pathways are Hexose transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC5A9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005412 | glucose:sodium symporter activity | IBA | 21873635 |
GO:0015370 | solute:sodium symporter activity | TAS | -- |
GO:0022857 | transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
2 | Hexose transport |
.85
|
|
3 | Metabolism |
.40
|
|
4 | Glycosaminoglycan metabolism | ||
5 | NRF2 pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006814 | sodium ion transport | IEA | -- |
GO:0008645 | hexose transmembrane transport | TAS | -- |
GO:0035725 | sodium ion transmembrane transport | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Empagliflozin (BI 10773) | Pharma | SGLT-2 inhibitor for oral treatment of type 2 diabetes | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
sodium |
|
7440-23-5 |
|
Compound | Action | Cas Number |
---|---|---|
Empagliflozin (BI 10773) | SGLT-2 inhibitor for oral treatment of type 2 diabetes | 864070-44-0 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SLC5A10 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SLC5A10 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | SLC5A10 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Slc5a10 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Slc5a10 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SLC5A10 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
chicken (Gallus gallus) |
Aves | SLC5A10 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | SLC5A10 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | slc5a10 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | si:dkeyp-9d4.5 32 |
|
||
SLC5A10 33 |
|
OneToOne |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000017554 | -- | 18,979,406(+) | GGG/GG | intron_variant | |
rs1000040617 | -- | 19,013,460(+) | G/A | coding_sequence_variant, intron_variant, missense_variant | |
rs1000108166 | -- | 19,005,577(+) | G/C | intron_variant | |
rs1000119288 | -- | 18,982,264(+) | C/G | intron_variant | |
rs1000156355 | -- | 18,968,490(+) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3116n100 | CNV | gain | 25217958 |
dgv5491n54 | CNV | gain | 21841781 |
dgv565e214 | CNV | gain | 21293372 |
dgv895e212 | CNV | loss | 25503493 |
esv1783904 | CNV | insertion | 17803354 |
esv2758678 | CNV | gain+loss | 17122850 |
esv3310541 | CNV | novel sequence insertion | 20981092 |
esv33572 | CNV | gain | 17666407 |
esv3424584 | CNV | duplication | 20981092 |
esv3572465 | CNV | gain | 25503493 |
esv3892975 | CNV | loss | 25118596 |
nsv1055999 | CNV | gain | 25217958 |
nsv1057803 | CNV | loss | 25217958 |
nsv428336 | CNV | gain+loss | 18775914 |
nsv457699 | CNV | gain | 19166990 |
nsv470581 | CNV | gain | 18288195 |
nsv474110 | CNV | novel sequence insertion | 20440878 |
nsv479430 | CNV | novel sequence insertion | 20440878 |
nsv523721 | CNV | gain | 19592680 |
nsv574552 | CNV | gain | 21841781 |
nsv7291 | OTHER | inversion | 18451855 |
nsv833390 | CNV | loss | 17160897 |
nsv833391 | CNV | loss | 17160897 |
nsv9504 | CNV | gain+loss | 18304495 |
nsv953842 | CNV | deletion | 24416366 |
No disorders were found for SLC5A10 Gene.