Aliases for SLC5A10 Gene
Aliases for SLC5A10 Gene
External Ids for SLC5A10 Gene
- HGNC: 23155
- Entrez Gene: 125206
- Ensembl: ENSG00000154025
- UniProtKB: A0PJK1
Previous GeneCards Identifiers for SLC5A10 Gene
- GC17P019062
- GC17P019054
- GC17P018794
- GC17P018796
- GC17P018853
- GC17P018422
Summaries for SLC5A10 Gene
-
This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for SLC5A10 Gene
SLC5A10 (Solute Carrier Family 5 Member 10) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC5A9.
UniProtKB/Swiss-Prot for SLC5A10 Gene
-
High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.
Additional gene information for SLC5A10 Gene
- Monarch Initiative
- Search for SLC5A10 at DataMed
- Search for SLC5A10 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A10 Gene
Genomics for SLC5A10 Gene
GeneHancer (GH) Regulatory Elements for SLC5A10 Gene
Promoters and enhancers for SLC5A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SLC5A10 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SLC5A10 Gene
Genomic Locations for SLC5A10 Gene
- chr17:18,950,345-19,022,595
- (GRCh38/hg38)
- Size:
- 72,251 bases
- Orientation:
- Plus strand
- chr17:18,853,658-18,925,908
- (GRCh37/hg19)
Genomic View for SLC5A10 Gene
Genes around SLC5A10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by Ensembl
- 17p11.2 by Entrez Gene
- 17p11.2 by HGNC
SLC5A10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC5A10 Gene
Proteins for SLC5A10 Gene
-
Protein details for SLC5A10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0PJK1-SC5AA_HUMAN
- Recommended name:
- Sodium/glucose cotransporter 5
- Protein Accession:
- A0PJK1
- A8MUC9
- B4DPI0
- B7WPR4
- Q6P5X0
- Q8IXM4
- Q96LQ1
Protein attributes for SLC5A10 Gene
- Size:
- 596 amino acids
- Molecular mass:
- 64342 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB71619.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};
Protein Expression for SLC5A10 Gene
Post-translational modifications for SLC5A10 Gene
No Post-translational modifications
Other Protein References for SLC5A10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for SLC5A10
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Protein Products
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Assay Products
No data available for DME Specific Peptides for SLC5A10 Gene
Domains & Families for SLC5A10 Gene
Gene Families for SLC5A10 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC5A10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC5A10 Gene
Graphical View of Domain Structure for InterPro Entry
A0PJK1UniProtKB/Swiss-Prot:
SC5AA_HUMAN :- Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
- Family:
-
- Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Function for SLC5A10 Gene
Molecular function for SLC5A10 Gene
- UniProtKB/Swiss-Prot Function:
- High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.
Phenotypes From GWAS Catalog for SLC5A10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005412 | glucose:sodium symporter activity | IBA | -- |
| GO:0015370 | solute:sodium symporter activity | TAS | -- |
Phenotypes for SLC5A10 Gene
- MGI mutant phenotypes for SLC5A10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC5A10:
Animal Models for SLC5A10 Gene
- MGI Knock Outs for SLC5A10:
-
- Slc5a10 tm1Csk
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-
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-
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miRNA for SLC5A10 Gene
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC5A10 Gene
Localization for SLC5A10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC5A10 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA,IDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC5A10 Gene
Pathways & Interactions for SLC5A10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 2 | Hexose transport |
.85
|
|
| 3 | Metabolism |
.37
|
|
| 4 | Glycosaminoglycan metabolism | ||
| 5 | NRF2 pathway | ||
Pathways by source for SLC5A10 Gene
1 BioSystems pathway for SLC5A10 Gene
5 Reactome pathways for SLC5A10 Gene
Interacting Proteins for SLC5A10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006814 | sodium ion transport | IBA | -- |
| GO:0008645 | hexose transport | TAS | -- |
| GO:0035725 | sodium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC5A10 Gene
Drugs & Compounds for SLC5A10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Empagliflozin (BI 10773) | Pharma | SGLT-2 inhibitor for oral treatment of type 2 diabetes | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sodium |
|
7440-23-5 |
|
(1) ApexBio Compounds for SLC5A10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Empagliflozin (BI 10773) | SGLT-2 inhibitor for oral treatment of type 2 diabetes | 864070-44-0 |
Transcripts for SLC5A10 Gene
mRNA/cDNA for SLC5A10 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (39) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC5A10 Gene
CRISPR Products
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OriGene CRISPR knockouts for SLC5A10
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Vectors and viruses for KO, Activation, Repression, and more
-
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SLC5A10 gene related products
- orf clones - Search results for available SLC5A10 gene related products
- Applied Biological Materials Clones for SLC5A10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SLC5A10 Gene
mRNA differential expression in normal tissues according to GTEx for SLC5A10 Gene
This gene is overexpressed in Kidney - Cortex (x46.2).
This gene is overexpressed in Urine (61.7) and Kidney (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC5A10 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC5A10 Gene:
SLC5A10SOURCE GeneReport for Unigene cluster for SLC5A10 Gene:
Hs.462418mRNA Expression by UniProt/SwissProt for SLC5A10 Gene:
A0PJK1-SC5AA_HUMAN
Tissue specificity:
Seems to be exclusively expressed in kidney.
Evidence on tissue expression from TISSUES for SLC5A10 Gene
- Kidney(4.5)
- Intestine(4.2)
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for SLC5A10
-
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC5A10 Gene
Orthologs for SLC5A10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC5A10 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SLC5A10 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC5A10 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc5a10 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc5a10 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC5A10 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | SLC5A10 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SLC5A10 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc5a10 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkeyp-9d4.5 33 |
|
||
| SLC5A10 34 |
|
OneToOne |
- Species where no ortholog for SLC5A10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SLC5A10 Gene
Variants for SLC5A10 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017554 | -- | 18,979,406(+) | GGG/GG | intron_variant | |
| rs1000040617 | -- | 19,013,460(+) | G/A | coding_sequence_variant, intron_variant, missense_variant | |
| rs1000108166 | -- | 19,005,577(+) | G/C | intron_variant | |
| rs1000119288 | -- | 18,982,264(+) | C/G | intron_variant | |
| rs1000156355 | -- | 18,968,490(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv953842 | CNV | deletion | 24416366 |
| nsv9504 | CNV | gain+loss | 18304495 |
| nsv833391 | CNV | loss | 17160897 |
| nsv833390 | CNV | loss | 17160897 |
| nsv7291 | OTHER | inversion | 18451855 |
| nsv574552 | CNV | gain | 21841781 |
| nsv523721 | CNV | gain | 19592680 |
| nsv479430 | CNV | novel sequence insertion | 20440878 |
| nsv474110 | CNV | novel sequence insertion | 20440878 |
| nsv470581 | CNV | gain | 18288195 |
| nsv457699 | CNV | gain | 19166990 |
| nsv428336 | CNV | gain+loss | 18775914 |
| nsv1057803 | CNV | loss | 25217958 |
| nsv1055999 | CNV | gain | 25217958 |
| esv3892975 | CNV | loss | 25118596 |
| esv3572465 | CNV | gain | 25503493 |
| esv3424584 | CNV | duplication | 20981092 |
| esv33572 | CNV | gain | 17666407 |
| esv3310541 | CNV | novel sequence insertion | 20981092 |
| esv2758678 | CNV | gain+loss | 17122850 |
| esv1783904 | CNV | insertion | 17803354 |
| dgv895e212 | CNV | loss | 25503493 |
| dgv565e214 | CNV | gain | 21293372 |
| dgv5491n54 | CNV | gain | 21841781 |
| dgv3116n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.46;
54.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC5A10 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A10 Gene
Disorders for SLC5A10 Gene
Additional Disease Information for SLC5A10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SLC5A10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC5A10 Gene
Publications for SLC5A10 Gene
- Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter. (PMID: 22212718) Grempler R … Eickelmann P (FEBS letters 2012) 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Fingerprints of hSGLT5 sugar and cation selectivity. (PMID: 24573086) Ghezzi C … Wright EM (American journal of physiology. Cell physiology 2014) 3 58
- Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58
- In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
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- genomics-online: primer clones - Search results for available SLC5A10 gene related products
- genomics-online: shRNA clones - Search results for available SLC5A10 gene related products
Sources for SLC5A10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew