Aliases for SLC51B Gene

Aliases for SLC51B Gene

  • Solute Carrier Family 51 Subunit Beta 2 3 4
  • Organic Solute Transporter Subunit Beta 3 4
  • Organic Solute Transporter Beta Subunit 2 3
  • Solute Carrier Family 51 Beta Subunit 3 5
  • OST-Beta 3 4
  • OSTB 3 4
  • OSTBETA 3

External Ids for SLC51B Gene

Previous GeneCards Identifiers for SLC51B Gene

  • GC15P065338
  • GC15P065420
  • GC15P065762
  • GC15P065078
  • GC15P065434
  • GC15P069494
  • GC15P069600
  • GC15P069653
  • GC15P065463
  • GC15P066309
  • GC15P066857
  • GC15P067386
  • GC15P067909
  • GC15P068399
  • GC15P068907
  • GC15P069383

Summaries for SLC51B Gene

GeneCards Summary for SLC51B Gene

SLC51B (Solute Carrier Family 51 Subunit Beta) is a Protein Coding gene. Diseases associated with SLC51B include Extrahepatic Cholestasis and Cholestasis. Among its related pathways are Drug Induction of Bile Acid Pathway and Bile secretion. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transporter activity.

UniProtKB/Swiss-Prot Summary for SLC51B Gene

  • Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.

Gene Wiki entry for SLC51B Gene

Additional gene information for SLC51B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC51B Gene

Genomics for SLC51B Gene

GeneHancer (GH) Regulatory Elements for SLC51B Gene

Promoters and enhancers for SLC51B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J065042 Promoter/Enhancer 1.3 Ensembl ENCODE 500.7 -0.7 -671 4.5 EP300 FOXK2 ZNF217 TCF12 POLR2G NCOR1 KDM6A TCF7 ZBTB25 TGIF2 SLC51B SPG21 UBAP1L MTFMT RASL12
GH15J065064 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13 +23.6 23645 7.2 BCLAF1 FOS ZBTB5 EZH2 NR2F2 PHF8 FOSL1 ZFHX2 PKNOX1 NR2F1 RASL12 UBAP1L SPG21 SLC51B RBPMS2 piR-31470-194 piR-32214-224
GH15J065093 Enhancer 1 Ensembl ENCODE dbSUPER 11.7 +49.5 49463 2.6 CREB1 ZFHX2 SMAD4 RXRA GLIS1 RARA ATF2 CEBPB NFIL3 PAF1 SLC51B CILP RNU5B-1 RBPMS2 lnc-UBAP1L-1 lnc-PDCD7-1 UBAP1L
GH15J065048 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 0.7 +4.5 4516 1.9 ZBTB40 ZNF217 EP300 USF1 SP1 FOS SAP30 REST RFX1 USF2 ENSG00000277351 piR-32214-224 SPG21 UBAP1L MTFMT RASL12 KBTBD13 MIR1272 ANKDD1A SLC51B
GH15J065032 Enhancer 1.1 ENCODE CraniofacialAtlas 0.4 -12.0 -12015 1.2 FOXK2 ZNF217 CTCF TCF12 MYC USF1 KDM6A REST CUX1 ZBTB25 RASL12 KBTBD13 RNU5B-1 MTFMT SLC51B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC51B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC51B

Genomic Locations for SLC51B Gene

Genomic Locations for SLC51B Gene
chr15:65,045,370-65,053,397
(GRCh38/hg38)
Size:
8,028 bases
Orientation:
Plus strand
chr15:65,337,708-65,345,734
(GRCh37/hg19)
Size:
8,027 bases
Orientation:
Plus strand

Genomic View for SLC51B Gene

Genes around SLC51B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC51B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC51B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC51B Gene

Proteins for SLC51B Gene

  • Protein details for SLC51B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW2-OSTB_HUMAN
    Recommended name:
    Organic solute transporter subunit beta
    Protein Accession:
    Q86UW2
    Secondary Accessions:
    • Q3SYF5

    Protein attributes for SLC51B Gene

    Size:
    128 amino acids
    Molecular mass:
    14346 Da
    Quaternary structure:
    • Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane (By similarity).

neXtProt entry for SLC51B Gene

Post-translational modifications for SLC51B Gene

No Post-translational modifications

Other Protein References for SLC51B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC51B Gene

Domains & Families for SLC51B Gene

Gene Families for SLC51B Gene

Protein Domains for SLC51B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC51B Gene

GenScript: Design optimal peptide antigens:
  • Organic solute transporter subunit beta (OSTB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UW2

UniProtKB/Swiss-Prot:

OSTB_HUMAN :
  • The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).
  • Belongs to the OST-beta family.
Domain:
  • The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).
Family:
  • Belongs to the OST-beta family.
genes like me logo Genes that share domains with SLC51B: view

Function for SLC51B Gene

Molecular function for SLC51B Gene

UniProtKB/Swiss-Prot Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
UniProtKB/Swiss-Prot Induction:
Positively regulated via NR1H4/FXR.

Phenotypes From GWAS Catalog for SLC51B Gene

Gene Ontology (GO) - Molecular Function for SLC51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015125 bile acid transmembrane transporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with SLC51B: view
genes like me logo Genes that share phenotypes with SLC51B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC51B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC51B Gene

Localization for SLC51B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC51B Gene

Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC51B gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12719432
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,ISS --
GO:0016323 basolateral plasma membrane IEA,IDA 16317684
GO:0032991 protein-containing complex ISS,IEA --
genes like me logo Genes that share ontologies with SLC51B: view

Pathways & Interactions for SLC51B Gene

PathCards logo

SuperPathways for SLC51B Gene

genes like me logo Genes that share pathways with SLC51B: view

Pathways by source for SLC51B Gene

1 BioSystems pathway for SLC51B Gene
1 KEGG pathway for SLC51B Gene

Interacting Proteins for SLC51B Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000335292 Q86UW2-OSTB_HUMAN for SLC51B Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for SLC51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015721 bile acid and bile salt transport ISS --
GO:0031647 regulation of protein stability ISS,IEA --
GO:0032782 bile acid secretion IPI 16317684
GO:0055085 transmembrane transport IEA --
GO:0060050 positive regulation of protein glycosylation IEA,ISS --
genes like me logo Genes that share ontologies with SLC51B: view

No data available for SIGNOR curated interactions for SLC51B Gene

Drugs & Compounds for SLC51B Gene

(6) Drugs for SLC51B Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Digoxin Approved Pharma Transporter, substrate Na+/K+ ATPase inhibitor 170
conjugated estrogens Approved Pharma Transporter, substrate 0
Dinoprostone Approved Pharma Transporter, substrate activates the PGE2 receptor, Major endogenous prostanoid 128
Taurocholic acid Approved, Experimental Pharma Transporter, substrate 0

(2) Additional Compounds for SLC51B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC51B: view

Transcripts for SLC51B Gene

mRNA/cDNA for SLC51B Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC51B

Alternative Splicing Database (ASD) splice patterns (SP) for SLC51B Gene

No ASD Table

Relevant External Links for SLC51B Gene

GeneLoc Exon Structure for
SLC51B

Expression for SLC51B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC51B Gene

mRNA differential expression in normal tissues according to GTEx for SLC51B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x11.3) and Colon - Transverse (x10.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC51B

SOURCE GeneReport for Unigene cluster for SLC51B Gene:

Hs.534533

mRNA Expression by UniProt/SwissProt for SLC51B Gene:

Q86UW2-OSTB_HUMAN
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.

Evidence on tissue expression from TISSUES for SLC51B Gene

  • Liver(4.5)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with SLC51B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC51B Gene

Orthologs for SLC51B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC51B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC51B 31 30
  • 99.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC51B 31 30
  • 78.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc51b 17 31 30
  • 76.46 (n)
cow
(Bos Taurus)
Mammalia SLC51B 31 30
  • 76.04 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc51b 30
  • 73.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC51B 31
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC51B 31
  • 37 (a)
OneToOne
Species where no ortholog for SLC51B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC51B Gene

ENSEMBL:
Gene Tree for SLC51B (if available)
TreeFam:
Gene Tree for SLC51B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC51B: view image

Paralogs for SLC51B Gene

No data available for Paralogs for SLC51B Gene

Variants for SLC51B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC51B Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
804474 Likely Pathogenic: Cholestasis; Diarrhea 65,050,082(+) GT/G FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for SLC51B Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC51B Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565

Variation tolerance for SLC51B Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC51B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC51B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC51B Gene

Disorders for SLC51B Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC51B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
extrahepatic cholestasis
  • extrahepatic biliary stasis
cholestasis
  • bile occlusion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC51B

genes like me logo Genes that share disorders with SLC51B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC51B Gene

Publications for SLC51B Gene

  1. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. (PMID: 12719432) Seward DJ … Ballatori N (The Journal of biological chemistry 2003) 2 3 4 23 54
  2. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PMID: 16269519) Landrier JF … Kullak-Ublick GA (American journal of physiology. Gastrointestinal and liver physiology 2006) 3 4 23 54
  3. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PMID: 16251721) Lee H … Edwards PA (Journal of lipid research 2006) 3 4 23 54
  4. Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. (PMID: 20538072) Dawson PA … Rao A (Biochimica et biophysica acta 2010) 2 3 54
  5. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PMID: 16423920) Boyer JL … Ballatori N (American journal of physiology. Gastrointestinal and liver physiology 2006) 3 23 54

Products for SLC51B Gene

Sources for SLC51B Gene