Aliases for SLC4A2 Gene
External Ids for SLC4A2 Gene
Previous HGNC Symbols for SLC4A2 Gene
Previous GeneCards Identifiers for SLC4A2 Gene
This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]
GeneCards Summary for SLC4A2 Gene
SLC4A2 (Solute Carrier Family 4 Member 2) is a Protein Coding gene. Diseases associated with SLC4A2 include Renal Tubular Acidosis and Cholestasis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. Gene Ontology (GO) annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A3.
UniProtKB/Swiss-Prot Summary for SLC4A2 Gene
Plasma membrane anion exchange protein of wide distribution.