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Aliases for SLC4A2 Gene

Aliases for SLC4A2 Gene

  • Solute Carrier Family 4 Member 2 2 3 4 5
  • Solute Carrier Family 4 (Anion Exchanger), Member 2 2 3
  • Erythrocyte Membrane Protein Band 3-Like 1 2 3
  • Non-Erythroid Band 3-Like Protein 3 4
  • Anion Exchanger 2 Type B1 2 3
  • Anion Exchanger 2 Type B2 2 3
  • Anion Exchanger 2 Type A 2 3
  • EPB3L1 3 4
  • BND3L 3 4
  • HKB3 3 4
  • AE2 3 4
  • Solute Carrier Family 4, Anion Exchanger, Member 2 (Erythrocyte Membrane Protein Band 3-Like 1) 2
  • Anion Exchange Protein 2 3
  • Anion Exchanger 2 4
  • NBND3 3
  • MPB3L 4
  • AE 2 4

External Ids for SLC4A2 Gene

Previous HGNC Symbols for SLC4A2 Gene

  • EPB3L1
  • AE2

Previous GeneCards Identifiers for SLC4A2 Gene

  • GC07P149003
  • GC07P150072
  • GC07P150148
  • GC07P150194
  • GC07P150387
  • GC07P150754
  • GC07P144569

Summaries for SLC4A2 Gene

Entrez Gene Summary for SLC4A2 Gene

  • This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]

GeneCards Summary for SLC4A2 Gene

SLC4A2 (Solute Carrier Family 4 Member 2) is a Protein Coding gene. Diseases associated with SLC4A2 include Primary Biliary Cirrhosis and Autoimmune Disease Of Urogenital Tract. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. Gene Ontology (GO) annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A3.

UniProtKB/Swiss-Prot for SLC4A2 Gene

  • Plasma membrane anion exchange protein of wide distribution.

Gene Wiki entry for SLC4A2 Gene

Additional gene information for SLC4A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A2 Gene

Genomics for SLC4A2 Gene

GeneHancer (GH) Regulatory Elements for SLC4A2 Gene

Promoters and enhancers for SLC4A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J151056 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.8 +3.2 3232 7.6 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SLC4A2 GC07P151061 CDK5 ENSG00000244151 NUB1 ENSG00000243433 ABCB8 TMUB1 AGAP3 ATG9B
GH07J151055 Promoter 0.5 EPDnew 650.7 -1.9 -1860 0.1 SLC4A2 RARRES2 CDK5 ASIC3
GH07J151084 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 13.6 +30.6 30578 5.9 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AGAP3 GC07M151084 ENSG00000243433 SLC4A2 FASTK CDK5 ASIC3 SMARCD3 GBX1 ASB10
GH07J151245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +192.1 192147 9.1 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF2 YY1 ZNF143 KLF13 ZNF263 SMARCD3 ENSG00000243018 ENSG00000244151 NUB1 ABCF2 ASB10 GBX1 ENSG00000229591 SLC4A2 TMUB1
GH07J150978 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.8 -77.8 -77849 3.1 ATF1 ARNT ARID4B SIN3A GLI4 GLIS2 KLF7 ATF7 MCM3 SP3 KCNH2 NUB1 ENSG00000244151 SLC4A2 NOS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC4A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC4A2 gene promoter:
  • RSRFC4
  • p53
  • p300
  • HOXA5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for SLC4A2 Gene

Genomic Locations for SLC4A2 Gene
19,318 bases
Plus strand
19,318 bases
Plus strand

Genomic View for SLC4A2 Gene

Genes around SLC4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A2 Gene

Proteins for SLC4A2 Gene

  • Protein details for SLC4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Anion exchange protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R6T0
    • B4DIT0
    • D3DX05
    • F8W682
    • Q45EY5
    • Q969L3

    Protein attributes for SLC4A2 Gene

    1241 amino acids
    Molecular mass:
    137009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A2 Gene


neXtProt entry for SLC4A2 Gene

Post-translational modifications for SLC4A2 Gene

  • Glycosylation at isoforms=3, 2882, isoforms=3, 2868, and posLast=859859
  • Ubiquitination at posLast=658658
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SLC4A2
  • Boster Bio Antibodies for SLC4A2
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC4A2

No data available for DME Specific Peptides for SLC4A2 Gene

Domains & Families for SLC4A2 Gene

Gene Families for SLC4A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anion exchanger (TC 2.A.31) family.
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A2: view

Function for SLC4A2 Gene

Molecular function for SLC4A2 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane anion exchange protein of wide distribution.
GENATLAS Biochemistry:
solute carrier family 4 (chloride-bicarbonate,anion exchange),member 2

Phenotypes From GWAS Catalog for SLC4A2 Gene

Gene Ontology (GO) - Molecular Function for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity TAS --
GO:0008509 anion transmembrane transporter activity TAS 3015590
GO:0008510 sodium:bicarbonate symporter activity IBA --
GO:0015297 antiporter activity IEA --
GO:0015301 anion:anion antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC4A2: view
genes like me logo Genes that share phenotypes with SLC4A2: view

Animal Models for SLC4A2 Gene

MGI Knock Outs for SLC4A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC4A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC4A2 Gene

Localization for SLC4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC4A2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA,TAS 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC4A2: view

Pathways & Interactions for SLC4A2 Gene

genes like me logo Genes that share pathways with SLC4A2: view

Gene Ontology (GO) - Biological Process for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006820 anion transport TAS 3015590
GO:0007283 spermatogenesis IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with SLC4A2: view

No data available for SIGNOR curated interactions for SLC4A2 Gene

Drugs & Compounds for SLC4A2 Gene

(3) Drugs for SLC4A2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for SLC4A2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC4A2: view

Transcripts for SLC4A2 Gene

Unigene Clusters for SLC4A2 Gene

Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP7: - - - - - - -
SP8: -
SP10: - - - - -
SP11: - - - -
SP19: - - -

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP14: -
SP17: -

ExUns: 30a · 30b ^ 31 ^ 32

Relevant External Links for SLC4A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC4A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC4A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.6), Stomach (12.1), and Placenta (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC4A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC4A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC4A2 Gene:


Evidence on tissue expression from TISSUES for SLC4A2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Pancreas(2.5)
  • Eye(2.4)
  • Intestine(2.2)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with SLC4A2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC4A2 Gene

Orthologs for SLC4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC4A2 34 33
  • 99.49 (n)
(Canis familiaris)
Mammalia SLC4A2 34 33
  • 90.35 (n)
(Bos Taurus)
Mammalia SLC4A2 34 33
  • 89.81 (n)
(Monodelphis domestica)
Mammalia SLC4A2 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Slc4a2 33
  • 87.91 (n)
(Mus musculus)
Mammalia Slc4a2 16 34 33
  • 87.57 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 30 (a)
(Gallus gallus)
Aves SLC4A2 34 33
  • 78.09 (n)
(Anolis carolinensis)
Reptilia SLC4A2 34
  • 60 (a)
(Danio rerio)
Actinopterygii slc4a2b 34 33
  • 67.46 (n)
slc4a2a 34
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006115 33
  • 57.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8177 34 35 33
  • 54.07 (n)
(Caenorhabditis elegans)
Secernentea abts-4 34
  • 28 (a)
R03E9.3 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOR1 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06450 33
  • 42.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for SLC4A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC4A2 Gene

Gene Tree for SLC4A2 (if available)
Gene Tree for SLC4A2 (if available)
Evolutionary constrained regions (ECRs) for SLC4A2: view image

Paralogs for SLC4A2 Gene

Paralogs for SLC4A2 Gene

(13) SIMAP similar genes for SLC4A2 Gene using alignment to 13 proteins:

  • B3A2_HUMAN
  • C9J035_HUMAN
  • C9J459_HUMAN
  • C9J722_HUMAN
  • C9J9M9_HUMAN
  • Q99654_HUMAN
genes like me logo Genes that share paralogs with SLC4A2: view

Variants for SLC4A2 Gene

Sequence variations from dbSNP and Humsavar for SLC4A2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs375977483 uncertain-significance, not provided 151,066,584(+) G/A coding_sequence_variant, missense_variant
rs376056989 uncertain-significance, not provided 151,064,244(+) G/A coding_sequence_variant, missense_variant
rs387907518 uncertain-significance, not provided 151,076,091(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs387907519 uncertain-significance, not provided 151,071,739(+) G/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs387907520 uncertain-significance, not provided 151,075,646(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A2 Gene

Variant ID Type Subtype PubMed ID
dgv11724n54 CNV loss 21841781
dgv3695n106 OTHER inversion 24896259
dgv6756n100 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv465215 CNV loss 19166990
nsv517508 CNV loss 19592680
nsv524928 CNV gain 19592680
nsv526410 CNV loss 19592680
nsv6004 CNV insertion 18451855
nsv831188 CNV loss 17160897
nsv951648 CNV deletion 24416366

Variation tolerance for SLC4A2 Gene

Residual Variation Intolerance Score: 3.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC4A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A2 Gene

Disorders for SLC4A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC4A2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC4A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC4A2 Gene

Publications for SLC4A2 Gene

  1. Genetic factors of susceptibility and of severity in primary biliary cirrhosis. (PMID: 18930330) Poupon R … Barbu V (Journal of hepatology 2008) 3 22 44 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SLC4A2 Gene

Sources for SLC4A2 Gene

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