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Aliases for SLC4A1AP Gene

Aliases for SLC4A1AP Gene

  • Solute Carrier Family 4 Member 1 Adaptor Protein 2 3 5
  • Solute Carrier Family 4 (Anion Exchanger), Member 1, Adapter Protein 2 3
  • Solute Carrier Family 4 (Anion Exchanger), Member 1, Adaptor Protein 2 3
  • Solute Carrier Family 4 Anion Exchanger Member 1 Adapter Protein 3 4
  • Kidney Anion Exchanger Adapter Protein 3 4
  • Human Lung Cancer Oncogene 3 Protein 3 4
  • Lung Cancer Oncogene 3 2 3
  • HLC-3 3 4
  • Kidney Anion Exchanger Adaptor Protein 3
  • Kanadaptin 3
  • HLC3 3

External Ids for SLC4A1AP Gene

Previous GeneCards Identifiers for SLC4A1AP Gene

  • GC02P027807
  • GC02P027978
  • GC02P027844
  • GC02P027861
  • GC02P027862
  • GC02P027797
  • GC02P027739
  • GC02P027886
  • GC02P027627

Summaries for SLC4A1AP Gene

GeneCards Summary for SLC4A1AP Gene

SLC4A1AP (Solute Carrier Family 4 Member 1 Adaptor Protein) is a Protein Coding gene. An important paralog of this gene is PPP1R8.

Additional gene information for SLC4A1AP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A1AP Gene

Genomics for SLC4A1AP Gene

GeneHancer (GH) Regulatory Elements for SLC4A1AP Gene

Promoters and enhancers for SLC4A1AP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.7 +0.2 175 2.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SUPT7L SLC4A1AP IFT172 GTF3C2 CAD ZNF512 GPN1 NRBP1 EIF2B4 SNX17
GH02I027663 Promoter 0.5 EPDnew 550.8 -1.3 -1274 0.1 SUPT7L SLC4A1AP PIR62267 GC02M027478
GH02I027680 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.8 +19.1 19106 3.5 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 ARID2 ZNF207 ZNF143 LINC01460 SLC4A1AP GPN1 CCDC121 ZNF512 C2orf16 SUPT7L LOC105374378 GC02M027478
GH02I027684 Enhancer 0.6 ENCODE dbSUPER 21.2 +22.3 22337 2.7 ZNF316 ZNF512 MAFK SLC4A1AP SUPT7L LINC01460 CCDC121 GPN1 ZNF512 C2orf16 KRTCAP3 OST4 LOC105374378
GH02I027884 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.4 +225.2 225194 7.5 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 SP3 PPARGC1A MEF2D RBKS BABAM2 TRMT61B KRTCAP3 FNDC4 SLC4A1AP BRE-AS1 GC02P027841 MRPL33 GC02M027478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC4A1AP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC4A1AP gene promoter:

Genomic Locations for SLC4A1AP Gene

Genomic Locations for SLC4A1AP Gene
31,510 bases
Plus strand

Genomic View for SLC4A1AP Gene

Genes around SLC4A1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC4A1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC4A1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A1AP Gene

Proteins for SLC4A1AP Gene

  • Protein details for SLC4A1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NJ39
    • Q4KMT1
    • Q4KMX0
    • Q7Z5Q9
    • Q9NVN2

    Protein attributes for SLC4A1AP Gene

    796 amino acids
    Molecular mass:
    88814 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAN12269.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC4A1AP Gene

neXtProt entry for SLC4A1AP Gene

Post-translational modifications for SLC4A1AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC4A1AP Gene

No data available for DME Specific Peptides for SLC4A1AP Gene

Domains & Families for SLC4A1AP Gene

Gene Families for SLC4A1AP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SLC4A1AP Gene

Suggested Antigen Peptide Sequences for SLC4A1AP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLC4A1AP: view

No data available for UniProtKB/Swiss-Prot for SLC4A1AP Gene

Function for SLC4A1AP Gene

Phenotypes From GWAS Catalog for SLC4A1AP Gene

Gene Ontology (GO) - Molecular Function for SLC4A1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 17553790
genes like me logo Genes that share ontologies with SLC4A1AP: view

Phenotypes for SLC4A1AP Gene

GenomeRNAi human phenotypes for SLC4A1AP:
genes like me logo Genes that share phenotypes with SLC4A1AP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC4A1AP Gene

Localization for SLC4A1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A1AP Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC4A1AP gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC4A1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLC4A1AP: view

Pathways & Interactions for SLC4A1AP Gene

SuperPathways for SLC4A1AP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC4A1AP Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC4A1AP Gene

Drugs & Compounds for SLC4A1AP Gene

No Compound Related Data Available

Transcripts for SLC4A1AP Gene

Unigene Clusters for SLC4A1AP Gene

Solute carrier family 4 (anion exchanger), member 1, adaptor protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A1AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP6: -

Relevant External Links for SLC4A1AP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC4A1AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC4A1AP Gene

Protein differential expression in normal tissues from HIPED for SLC4A1AP Gene

This gene is overexpressed in Lung (29.3) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC4A1AP Gene

Protein tissue co-expression partners for SLC4A1AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC4A1AP Gene:


SOURCE GeneReport for Unigene cluster for SLC4A1AP Gene:


mRNA Expression by UniProt/SwissProt for SLC4A1AP Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SLC4A1AP Gene

  • Liver(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC4A1AP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC4A1AP Gene

Orthologs for SLC4A1AP Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A1AP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC4A1AP 33 34
  • 99.58 (n)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
  • 86.98 (n)
-- 34
  • 86 (a)
(Canis familiaris)
Mammalia SLC4A1AP 33
  • 88.24 (n)
-- 34
  • 81 (a)
-- 34
  • 81 (a)
-- 34
  • 79 (a)
(Rattus norvegicus)
Mammalia Slc4a1ap 33
  • 82.61 (n)
(Mus musculus)
Mammalia Slc4a1ap 33 16 34
  • 82.35 (n)
(Ornithorhynchus anatinus)
Mammalia SLC4A1AP 34
  • 75 (a)
(Monodelphis domestica)
Mammalia SLC4A1AP 34
  • 69 (a)
(Gallus gallus)
Aves SLC4A1AP 33 34
  • 72.59 (n)
(Anolis carolinensis)
Reptilia SLC4A1AP 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a1ap 33
  • 65.99 (n)
Str.11601 33
(Danio rerio)
Actinopterygii slc4a1ap 33 34
  • 62.3 (n)
Dr.11762 33
fruit fly
(Drosophila melanogaster)
Insecta CG7706 35 33 34
  • 49.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004588 33
  • 49.07 (n)
(Caenorhabditis elegans)
Secernentea ZK632.2 35 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for SLC4A1AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A1AP Gene

Gene Tree for SLC4A1AP (if available)
Gene Tree for SLC4A1AP (if available)

Paralogs for SLC4A1AP Gene

Paralogs for SLC4A1AP Gene Pseudogenes for SLC4A1AP Gene

genes like me logo Genes that share paralogs with SLC4A1AP: view

Variants for SLC4A1AP Gene

Sequence variations from dbSNP and Humsavar for SLC4A1AP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000045824 -- 27,681,781(+) C/G intron_variant
rs1000103681 -- 27,689,211(+) C/T intron_variant
rs1000183570 -- 27,661,651(+) C/T upstream_transcript_variant
rs1000322375 -- 27,673,212(+) T/G intron_variant
rs1000382792 -- 27,674,299(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A1AP Gene

Variant ID Type Subtype PubMed ID
esv2660490 CNV deletion 23128226
esv3448213 CNV insertion 20981092
esv3590144 CNV loss 21293372
nsv1151664 CNV insertion 26484159

Variation tolerance for SLC4A1AP Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.90; 79.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC4A1AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A1AP Gene

Disorders for SLC4A1AP Gene

Additional Disease Information for SLC4A1AP

No disorders were found for SLC4A1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC4A1AP Gene

Publications for SLC4A1AP Gene

  1. Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. (PMID: 15764369) Kittanakom S … Reithmeier RA (Molecular membrane biology 2004) 3 4 22 58
  2. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. (PMID: 9422766) Chen J … Al-Awqati Q (The Journal of biological chemistry 1998) 2 3 22 58
  3. A comprehensive genetic association study of Alzheimer disease in African Americans. (PMID: 22159054) Logue MW … Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study Group (Archives of neurology 2011) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for SLC4A1AP Gene

Sources for SLC4A1AP Gene

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