This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located... See more...

Aliases for SLC47A2 Gene

Aliases for SLC47A2 Gene

  • Solute Carrier Family 47 Member 2 2 3 4 5
  • MATE2 2 3 4
  • Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 2 2 3
  • Kidney-Specific H(+)/Organic Cation Antiporter 3 4
  • Multidrug And Toxin Extrusion Protein 2 3 4
  • MATE2-K 2 3
  • Multidrug And Toxin Extrusion 2 2
  • FLJ31196 2
  • MATE2-B 3
  • SLC47A2 5
  • HMATE-2 4
  • MATE2K 3
  • MATE-2 4

External Ids for SLC47A2 Gene

Previous GeneCards Identifiers for SLC47A2 Gene

  • GC17M019524
  • GC17M019582
  • GC17M018960

Summaries for SLC47A2 Gene

Entrez Gene Summary for SLC47A2 Gene

  • This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC47A2 Gene

SLC47A2 (Solute Carrier Family 47 Member 2) is a Protein Coding gene. Diseases associated with SLC47A2 include Thiamine Metabolism Dysfunction Syndrome 2 and Type 2 Diabetes Mellitus. Among its related pathways are Atenolol Pathway, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include antiporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC47A1.

UniProtKB/Swiss-Prot Summary for SLC47A2 Gene

  • Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Wiki entry for SLC47A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC47A2 Gene

Genomics for SLC47A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC47A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC47A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC47A2

Top Transcription factor binding sites by QIAGEN in the SLC47A2 gene promoter:
  • C/EBPalpha
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for SLC47A2 Gene

Latest Assembly
chr17:19,678,288-19,719,598
(GRCh38/hg38)
Size:
41,311 bases
Orientation:
Minus strand

Previous Assembly
chr17:19,581,630-19,622,292
(GRCh37/hg19 by Entrez Gene)
Size:
40,663 bases
Orientation:
Minus strand

chr17:19,581,601-19,622,292
(GRCh37/hg19 by Ensembl)
Size:
40,692 bases
Orientation:
Minus strand

Genomic View for SLC47A2 Gene

Genes around SLC47A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC47A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC47A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC47A2 Gene

Proteins for SLC47A2 Gene

  • Protein details for SLC47A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VL8-S47A2_HUMAN
    Recommended name:
    Multidrug and toxin extrusion protein 2
    Protein Accession:
    Q86VL8
    Secondary Accessions:
    • A0JBX9
    • A0P8Z7
    • Q63HJ9
    • Q8IV44
    • Q96NA1

    Protein attributes for SLC47A2 Gene

    Size:
    602 amino acids
    Molecular mass:
    65085 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 6]: Inactive.

    Alternative splice isoforms for SLC47A2 Gene

neXtProt entry for SLC47A2 Gene

Post-translational modifications for SLC47A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC47A2 Gene

Domains & Families for SLC47A2 Gene

Gene Families for SLC47A2 Gene

Protein Domains for SLC47A2 Gene

InterPro:
Blocks:
  • Multi antimicrobial extrusion protein MatE

Suggested Antigen Peptide Sequences for SLC47A2 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 47 member 2 (S47A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86VL8

UniProtKB/Swiss-Prot:

S47A2_HUMAN :
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Family:
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
genes like me logo Genes that share domains with SLC47A2: view

Function for SLC47A2 Gene

Molecular function for SLC47A2 Gene

UniProtKB/Swiss-Prot Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.76 mM for TEA {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=0.11 mM for MPP {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=0.12 mM for cimetidine {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=1.98 mM for metformin {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=4.2 mM for guanidine {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=1.58 mM for procainamide {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=0.06 mM for topotecan {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=0.85 mM for estrone sulfate {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=4.32 mM for acyclovir {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; KM=4.28 mM for ganciclovir {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.88 nmol/min/mg enzyme toward TEA {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.575 nmol/min/mg enzyme toward MPP {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.115 nmol/min/mg enzyme toward cimetidine {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.845 nmol/min/mg enzyme toward metformin {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.58 nmol/min/mg enzyme toward guanidine {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=3.385 nmol/min/mg enzyme toward procainamide {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.13 nmol/min/mg enzyme toward topotecan {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.945 nmol/min/mg enzyme toward acyclovir {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; Vmax=0.805 nmol/min/mg enzyme toward ganciclovir {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534}; pH dependence: Optimum pH is 9.0. Active from pH 6 to 9. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:17509534};

Phenotypes From GWAS Catalog for SLC47A2 Gene

Gene Ontology (GO) - Molecular Function for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0022857 transmembrane transporter activity IBA 21873635
GO:0042910 xenobiotic transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC47A2: view
genes like me logo Genes that share phenotypes with SLC47A2: view

miRNA for SLC47A2 Gene

miRTarBase miRNAs that target SLC47A2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC47A2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC47A2 Gene

Localization for SLC47A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC47A2 Gene

Cell membrane. Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC47A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC47A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC47A2 Gene

Pathways & Interactions for SLC47A2 Gene

genes like me logo Genes that share pathways with SLC47A2: view

Gene Ontology (GO) - Biological Process for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042908 xenobiotic transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC47A2: view

No data available for SIGNOR curated interactions for SLC47A2 Gene

Drugs & Compounds for SLC47A2 Gene

(43) Drugs for SLC47A2 Gene - From: DrugBank, PharmGKB, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cimetidine Approved, Investigational Pharma Transporter, substrate, inhibitor, antagonist H2 receptor antagonist 113
Metformin Approved Pharma Transporter, substrate AMP-activated protein kinase (AMPK) activator 2304
abemaciclib Approved, Investigational Pharma Transporter, inhibitor 0
Acyclovir Approved Pharma Transporter, substrate 124
Amisulpride Approved, Investigational Pharma Transporter, substrate, inhibitor Dopamine D2/D3 receptor antagonist 66
genes like me logo Genes that share compounds with SLC47A2: view

Transcripts for SLC47A2 Gene

mRNA/cDNA for SLC47A2 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC47A2

Alternative Splicing Database (ASD) splice patterns (SP) for SLC47A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6:

Relevant External Links for SLC47A2 Gene

GeneLoc Exon Structure for
SLC47A2

Expression for SLC47A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC47A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC47A2 Gene

This gene is overexpressed in Kidney - Cortex (x37.8).

Protein differential expression in normal tissues from HIPED for SLC47A2 Gene

This gene is overexpressed in Kidney (54.3) and Spinal cord (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC47A2 Gene



Protein tissue co-expression partners for SLC47A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC47A2

SOURCE GeneReport for Unigene cluster for SLC47A2 Gene:

Hs.126830

mRNA Expression by UniProt/SwissProt for SLC47A2 Gene:

Q86VL8-S47A2_HUMAN
Tissue specificity: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.

Evidence on tissue expression from TISSUES for SLC47A2 Gene

  • Kidney(4.7)
  • Nervous system(4.4)
  • Intestine(4.4)
  • Urine(2.2)
genes like me logo Genes that share expression patterns with SLC47A2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC47A2 Gene

Orthologs for SLC47A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC47A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC47A2 29 30
  • 99.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC47A2 29 30
  • 82.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC47A2 29 30
  • 79.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC47A2 30
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC47A2 30
  • 54 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc47a2 30
  • 45 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SLC47A2 29 30
  • 63.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC47A2 30
  • 44 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-175a17.4 30
  • 35 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 30
  • 18 (a)
ManyToMany
ERC1 30
  • 17 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G23030 29
  • 43.72 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0571600 29
  • 46.69 (n)
Species where no ortholog for SLC47A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC47A2 Gene

ENSEMBL:
Gene Tree for SLC47A2 (if available)
TreeFam:
Gene Tree for SLC47A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC47A2: view image
Alliance of Genome Resources:
Additional Orthologs for SLC47A2

Paralogs for SLC47A2 Gene

Paralogs for SLC47A2 Gene

(1) SIMAP similar genes for SLC47A2 Gene using alignment to 2 proteins:

  • S47A2_HUMAN
  • C9JAE6_HUMAN

Pseudogenes.org Pseudogenes for SLC47A2 Gene

genes like me logo Genes that share paralogs with SLC47A2: view

Variants for SLC47A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC47A2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs138969135 Benign: not provided 19,708,463(-) C/T
NM_152908.4(SLC47A2):c.576G>A (p.Pro192=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON
rs34399035 -- p.Gly429Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC47A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC47A2 Gene

Variant ID Type Subtype PubMed ID
esv3582566 CNV loss 25503493
esv3640179 CNV loss 21293372
esv3892981 CNV gain 25118596
nsv1061317 CNV gain 25217958
nsv1061408 CNV gain 25217958
nsv1063892 CNV gain 25217958
nsv428337 CNV loss 18775914
nsv526290 CNV loss 19592680

Variation tolerance for SLC47A2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC47A2 Gene

Human Gene Mutation Database (HGMD)
SLC47A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC47A2
Leiden Open Variation Database (LOVD)
SLC47A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC47A2 Gene

Disorders for SLC47A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC47A2 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC47A2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC47A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC47A2 Gene

Publications for SLC47A2 Gene

  1. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PMID: 16996621) Omote H … Moriyama Y (Trends in pharmacological sciences 2006) 2 3 4
  2. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (PMID: 16807400) Masuda S … Inui K (Journal of the American Society of Nephrology : JASN 2006) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. (PMID: 20016398) Toyama K … Inui K (Pharmacogenetics and genomics 2010) 3 40
  5. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PMID: 17509534) Tanihara Y … Inui K (Biochemical pharmacology 2007) 3 4

Products for SLC47A2 Gene

Sources for SLC47A2 Gene