Aliases for SLC47A2 Gene
External Ids for SLC47A2 Gene
Previous GeneCards Identifiers for SLC47A2 Gene
This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC47A2 Gene
SLC47A2 (Solute Carrier Family 47 Member 2) is a Protein Coding gene. Diseases associated with SLC47A2 include Thiamine Metabolism Dysfunction Syndrome 2 and Type 2 Diabetes Mellitus. Among its related pathways are Atenolol Pathway, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include antiporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC47A1.
UniProtKB/Swiss-Prot Summary for SLC47A2 Gene
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.