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SLC46A2 (Solute Carrier Family 46 Member 2) is a Protein Coding gene. Diseases associated with SLC46A2 include Folate Malabsorption, Hereditary. Gene Ontology (GO) annotations related to this gene include symporter activity. An important paralog of this gene is SLC46A3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015293 | symporter activity | NAS | 10978518 |
GO:0022857 | transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,NAS | 10978518 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0043029 | T cell homeostasis | IEA | -- |
GO:0045580 | regulation of T cell differentiation | IEA | -- |
GO:0048538 | thymus development | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
GO:0070233 | negative regulation of T cell apoptotic process | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC46A2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC46A2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC46A2 30 |
|
||
TSCOT 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Slc46a2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc46a2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SLC46A2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC46A2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLC46A2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC46A2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487203 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100002406 30 |
|
||
SLC46A2 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG30344 31 |
|
ManyToMany | |
CG42514 31 |
|
ManyToMany | |||
CG8046 31 |
|
ManyToMany | |||
CG30345 31 |
|
ManyToMany | |||
CG8008 31 |
|
ManyToMany | |||
CG15553 31 |
|
ManyToMany | |||
CG15890 31 |
|
ManyToMany | |||
CG31321 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | Y4C6B.5 31 |
|
ManyToMany | |
Y43F8A.5 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs114822090 | Benign: not provided | 112,889,956(-) |
G/A NM_033051.4(SLC46A2):c.726C>T (p.Ala242=) |
SYNONYMOUS | |
rs16917454 | Benign: not provided. - | 112,889,585(-) |
G/Ap.Ala366Val NM_033051.4(SLC46A2):c.1097C>T (p.Ala366Val) |
MISSENSE | |
rs7021942 | Benign: not provided | 112,889,905(-) |
A/G NM_033051.4(SLC46A2):c.777T>C (p.Asp259=) |
SYNONYMOUS | |
rs7022287 | Benign: not provided | 112,889,923(-) |
G/A NM_033051.4(SLC46A2):c.759C>T (p.Tyr253=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422302 | CNV | deletion | 17116639 |
esv2759710 | CNV | gain | 17122850 |
nsv529036 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
folate malabsorption, hereditary |
|
|