SLC46A1 Gene (Protein Coding)

Solute Carrier Family 46 Member 1

GC17M029402
GIFtS:
45
This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter i... See more...

Aliases for SLC46A1 Gene

Aliases for SLC46A1 Gene

  • Solute Carrier Family 46 Member 1 2 3 4 5
  • Proton-Coupled Folate Transporter 2 3 4
  • Heme Carrier Protein 1 2 3 4
  • Solute Carrier Family 46 (Folate Transporter), Member 1 2 3
  • HCP1 3 4
  • PCFT 3 4
  • G21 3 4
  • Solute Carrier Family 46, Member 1 2
  • PCFT/HCP1 4

External Ids for SLC46A1 Gene

Previous GeneCards Identifiers for SLC46A1 Gene

  • GC17M023753
  • GC17M026721
  • GC17M022930
  • GC17M028397
  • GC17M028477
  • GC17M029280
  • GC17M029380
  • GC17M028560
  • GC17M028626
  • GC17M028711
  • GC17M028807
  • GC17M028912
  • GC17M029005
  • GC17M029107
  • GC17M029191

Summaries for SLC46A1 Gene

Entrez Gene Summary for SLC46A1 Gene

  • This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC46A1 Gene

SLC46A1 (Solute Carrier Family 46 Member 1) is a Protein Coding gene. Diseases associated with SLC46A1 include Folate Malabsorption, Hereditary and Folic Acid Deficiency Anemia. Among its related pathways are Insulin receptor recycling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and heme transporter activity. An important paralog of this gene is SLC46A3.

UniProtKB/Swiss-Prot Summary for SLC46A1 Gene

  • Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.

Gene Wiki entry for SLC46A1 Gene

Additional gene information for SLC46A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC46A1 Gene

Genomics for SLC46A1 Gene

GeneHancer (GH) Regulatory Elements for SLC46A1 Gene

Promoters and enhancers for SLC46A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC46A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC46A1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • PPAR-gamma2

Genomic Locations for SLC46A1 Gene

Genomic Locations for SLC46A1 Gene
chr17:28,394,642-28,407,197
(GRCh38/hg38)
Size:
12,556 bases
Orientation:
Minus strand
chr17:26,721,661-26,734,215
(GRCh37/hg19)
Size:
12,555 bases
Orientation:
Minus strand

Genomic View for SLC46A1 Gene

Genes around SLC46A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC46A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC46A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC46A1 Gene

Proteins for SLC46A1 Gene

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  • Protein details for SLC46A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NT5-PCFT_HUMAN
    Recommended name:
    Proton-coupled folate transporter
    Protein Accession:
    Q96NT5
    Secondary Accessions:
    • Q1HE20
    • Q86T92
    • Q8TEG3
    • Q96FL0

    Protein attributes for SLC46A1 Gene

    Size:
    459 amino acids
    Molecular mass:
    49771 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for SLC46A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC46A1 Gene

Protein Expression for SLC46A1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC46A1 Gene

  • Glycosylation at Asn58 and Asn68
  • Ubiquitination at Lys262
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC46A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC46A1 Gene

Domains & Families for SLC46A1 Gene

Gene Families for SLC46A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC46A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC46A1 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 46 member 1 (PCFT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NT5

UniProtKB/Swiss-Prot:

PCFT_HUMAN :
  • Belongs to the major facilitator superfamily. SLC46A family.
Family:
  • Belongs to the major facilitator superfamily. SLC46A family.
genes like me logo Genes that share domains with SLC46A1: view

Function for SLC46A1 Gene

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Molecular function for SLC46A1 Gene

UniProtKB/Swiss-Prot Function:
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.3 uM for folic acid (at pH 5.5) {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17475902}; KM=1.5 uM for folic acid (at pH 6.0) {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17475902}; KM=2.7 uM for folic acid (at pH 6.5) {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17475902}; KM=6.0 uM for folic acid (at pH 7.0) {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17475902}; KM=56.2 uM for folic acid (at pH 7.5) {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17475902}; pH dependence: Optimum pH is 4.0-5.5. Activity decreases above pH 5.5 and reaches negligible levels at neutral pH and above. {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17475902};

Phenotypes From GWAS Catalog for SLC46A1 Gene

Gene Ontology (GO) - Molecular Function for SLC46A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IEA --
GO:0008517 folic acid transmembrane transporter activity TAS --
GO:0015078 proton transmembrane transporter activity IDA 17129779
GO:0015232 heme transporter activity TAS --
GO:0015350 methotrexate transmembrane transporter activity IC 19762432
genes like me logo Genes that share ontologies with SLC46A1: view
genes like me logo Genes that share phenotypes with SLC46A1: view

Human Phenotype Ontology for SLC46A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC46A1 Gene

MGI Knock Outs for SLC46A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC46A1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC46A1 Gene

Localization for SLC46A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC46A1 Gene

Apical cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC46A1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
endosome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC46A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane IDA,TAS --
GO:0009986 cell surface HDA 19581412
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC46A1: view

Pathways & Interactions for SLC46A1 Gene

genes like me logo Genes that share pathways with SLC46A1: view

Pathways by source for SLC46A1 Gene

1 BioSystems pathway for SLC46A1 Gene
1 PharmGKB pathway for SLC46A1 Gene

SIGNOR curated interactions for SLC46A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SLC46A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis TAS --
GO:0015884 folic acid transport IMP 17129779
GO:0015886 heme transport IEA --
GO:0046655 folic acid metabolic process TAS --
GO:0051958 methotrexate transport IMP 17129779
genes like me logo Genes that share ontologies with SLC46A1: view

Drugs & Compounds for SLC46A1 Gene

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  1. Drug

(13) Drugs for SLC46A1 Gene - From: DrugBank, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sulfasalazine Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor NF-κB activation inhibitor 76
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1757
Folic acid Approved, Vet_approved Nutra Transporter, substrate 4687
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, Full agonist, Inhibition, Inhibitor, inhibitor Cox inhibitor 141
Levomefolic acid Approved, Investigational Pharma Transporter, substrate Active form of folic acid 0
genes like me logo Genes that share compounds with SLC46A1: view

Transcripts for SLC46A1 Gene

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mRNA/cDNA for SLC46A1 Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC46A1 Gene

No ASD Table

Relevant External Links for SLC46A1 Gene

GeneLoc Exon Structure for
SLC46A1
ECgene alternative splicing isoforms for
SLC46A1

Expression for SLC46A1 Gene

Products:

  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC46A1 Gene

mRNA expression in normal human tissues for SLC46A1 Gene
mRNA expression by GTEx for SLC46A1 GenemRNA expression by BioGPS for SLC46A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC46A1 Gene

This gene is overexpressed in Adrenal Gland (x6.7) and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for SLC46A1 Gene

This gene is overexpressed in Fetal gut (15.0), Liver (8.2), Spinal cord (7.6), Placenta (6.6), and Rectum (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC46A1 Gene



Protein tissue co-expression partners for SLC46A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC46A1 Gene:

SLC46A1

SOURCE GeneReport for Unigene cluster for SLC46A1 Gene:

Hs.446689

mRNA Expression by UniProt/SwissProt for SLC46A1 Gene:

Q96NT5-PCFT_HUMAN
Tissue specificity: Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.

Evidence on tissue expression from TISSUES for SLC46A1 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Eye(4.2)
  • Spleen(4.2)
  • Intestine(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC46A1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • face
  • head
  • lip
  • mouth
  • tongue
Thorax:
  • diaphragm
  • esophagus
  • lung
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with SLC46A1: view

Orthologs for SLC46A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC46A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SLC46A1 33
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SLC46A1 33 32
  • 87.51 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Slc46a1 32
  • 84.43 (n)
cow
(Bos Taurus)
 Mammalia SLC46A1 33 32
  • 84.31 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Slc46a1 17 33 32
  • 83.95 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia SLC46A1 33
  • 67 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia SLC46A1 33
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SLC46A1 33 32
  • 64.75 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SLC46A1 33
  • 48 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia slc46a1 32
  • 62.75 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15282 32
zebrafish
(Danio rerio)
 Actinopterygii slc46a1 33 32
  • 59.7 (n)
 OneToOne
zgc56400 32
fruit fly
(Drosophila melanogaster)
 Insecta CG30344 33
  • 20 (a)
 ManyToMany
CG30345 33
  • 19 (a)
 ManyToMany
CG8046 33
  • 18 (a)
 ManyToMany
CG42514 33
  • 17 (a)
 ManyToMany
CG15553 33
  • 17 (a)
 ManyToMany
CG8008 33
  • 17 (a)
 ManyToMany
CG15890 33
  • 15 (a)
 ManyToMany
CG31321 33
  • 13 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea Y4C6B.5 33 32
  • 39.04 (n)
 ManyToMany
Y43F8A.5 33
  • 18 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 31 (a)
 OneToOne
Species where no ortholog for SLC46A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC46A1 Gene

ENSEMBL:
Gene Tree for SLC46A1 (if available)
TreeFam:
Gene Tree for SLC46A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC46A1: view image

Paralogs for SLC46A1 Gene

Paralogs for SLC46A1 Gene

(2) SIMAP similar genes for SLC46A1 Gene using alignment to 6 proteins:

  • PCFT_HUMAN
  • C9JSZ2_HUMAN
  • J3KTE6_HUMAN
  • J3QL21_HUMAN
  • J3QRF7_HUMAN
  • K7EPJ7_HUMAN
genes like me logo Genes that share paralogs with SLC46A1: view

Variants for SLC46A1 Gene

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Sequence variations from dbSNP and Humsavar for SLC46A1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs112801276 uncertain-significance, Congenital defect of folate absorption 28,398,964(-) T/A 3_prime_UTR_variant
rs1128161 benign, Congenital defect of folate absorption 28,394,876(-) G/A 3_prime_UTR_variant
rs1128162 benign, Congenital defect of folate absorption 28,394,772(-) C/A 3_prime_UTR_variant
rs114008979 uncertain-significance, Congenital defect of folate absorption 28,398,008(-) C/T 3_prime_UTR_variant
rs117397871 uncertain-significance, Congenital defect of folate absorption 28,395,340(-) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC46A1 Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv1062056 CNV gain 25217958
nsv574653 CNV gain 21841781

Variation tolerance for SLC46A1 Gene

Gene Damage Index Score: 1.55; 30.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC46A1 Gene

Human Gene Mutation Database (HGMD)
SLC46A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC46A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC46A1 Gene

Disorders for SLC46A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC46A1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
folate malabsorption, hereditary
  • hfm
folic acid deficiency anemia
  • folate deficiency anemia
thiamine metabolism dysfunction syndrome 2
  • thmd2
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PCFT_HUMAN
  • Hereditary folate malabsorption (HFM) [MIM:229050]: Rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. {ECO:0000269 PubMed:17129779, ECO:0000269 PubMed:17446347, ECO:0000269 PubMed:18559978, ECO:0000269 PubMed:20686069, ECO:0000269 PubMed:20805364, ECO:0000269 PubMed:21333572}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLC46A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC46A1: view

No data available for Genatlas for SLC46A1 Gene

Publications for SLC46A1 Gene

  1. Identification of an intestinal heme transporter. (PMID: 16143108) Shayeghi M … McKie AT (Cell 2005) 2 3 4 23 56
  2. Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants. (PMID: 19176287) Wang X … Eckfeldt JH (Blood cells, molecules & diseases 2009) 3 23 43 56
  3. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. (PMID: 17475902) Nakai Y … Yuasa H (The Journal of pharmacology and experimental therapeutics 2007) 3 4 26 56
  4. Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium. (PMID: 17335806) Sharma S … Della NG (Experimental cell research 2007) 3 4 23 56
  5. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. (PMID: 17129779) Qiu A … Goldman ID (Cell 2006) 2 3 4 56

ExternalLinks

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