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Aliases for SLC44A2 Gene
Aliases for SLC44A2 Gene
External Ids for SLC44A2 Gene
- HGNC: 17292
- Entrez Gene: 57153
- Ensembl: ENSG00000129353
- OMIM: 606106
- UniProtKB: Q8IWA5
Previous GeneCards Identifiers for SLC44A2 Gene
- GC19P010575
- GC19P010713
- GC19P010290
Summaries for SLC44A2 Gene
GeneCards Summary for SLC44A2 Gene
SLC44A2 (Solute Carrier Family 44 Member 2) is a Protein Coding gene. Diseases associated with SLC44A2 include Femoral Vein Thrombophlebitis and Deafness, Autosomal Recessive 68. Among its related pathways are Phospholipase D signaling pathway and Synthesis of PC. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and choline transmembrane transporter activity. An important paralog of this gene is SLC44A5.
UniProtKB/Swiss-Prot Summary for SLC44A2 Gene
-
Isoform 1, but not isoform 3, exhibits some choline transporter activity.
Additional gene information for SLC44A2 Gene
- HGNC(17292)
- Entrez Gene(57153)
- Ensembl(ENSG00000129353)
- OMIM(606106)
- UniProtKB(Q8IWA5)
- Open Targets Platform(ENSG00000129353)
- Monarch Initiative
- Search for SLC44A2 at DataMed
- Search for SLC44A2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC44A2 Gene
Genomics for SLC44A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC44A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC44A2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC44A2
- Top Transcription factor binding sites by QIAGEN in the SLC44A2 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- Ik-2
- NF-Y
- NF-YA
- Sp1
- USF-1
- USF1
Genomic Locations for SLC44A2 Gene
Genomic Locations for SLC44A2 Gene
- chr19:10,602,455-10,644,557
- (GRCh38/hg38)
- Size:
- 42,103 bases
- Orientation:
- Plus strand
- chr19:10,713,121-10,755,235
- (GRCh37/hg19)
- Size:
- 42,115 bases
- Orientation:
- Plus strand
Genomic View for SLC44A2 Gene
Genes around SLC44A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
SLC44A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC44A2 Gene
Proteins for SLC44A2 Gene
-
Protein details for SLC44A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IWA5-CTL2_HUMAN
- Recommended name:
- Choline transporter-like protein 2
- Protein Accession:
- Q8IWA5
- B2RBB1
- B3KNH3
- B4DFJ0
- F2Q9D7
- Q658V1
- Q658Z2
- Q6PJV7
- Q8N2F0
- Q9NY68
Protein attributes for SLC44A2 Gene
- Size:
- 706 amino acids
- Molecular mass:
- 80124 Da
- Quaternary structure:
-
- Interacts with COCH.
- SequenceCaution:
-
- Sequence=BAC11662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: Produced by alternative promoter usage.
Protein Expression for SLC44A2 Gene
Post-translational modifications for SLC44A2 Gene
Other Protein References for SLC44A2 Gene
Antibody Products
- LifeSpan BioSciences SLC44A2 / CTL2 Monoclonal Antibody and SLC44A2 / CTL2 Antibody
- Creative Diagnostics Anti-SLC44A2 monoclonal antibody, clone 4E22
-
Custom Antibody ServicesOriGene Antibodies for SLC44A2
- Novus Biologicals Antibodies for SLC44A2
-
Abcam antibodies for SLC44A2
- Invitrogen Antibodies for SLC44A2 (AFLGC-SLC44A2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC44A2
Protein Products
-
OriGene Purified Proteins for SLC44A2
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC44A2
- Origene Custom Protein Services for SLC44A2
- antibodies-online: Show 6 available SLC44A2 Proteins ranked by validation data
- Compare Top SLC44A2 Proteins
-
Quality Products:
-
Abcam proteins for SLC44A2
No data available for DME Specific Peptides for SLC44A2 Gene
Domains & Families for SLC44A2 Gene
Gene Families for SLC44A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SLC44A2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC44A2 Gene
- GenScript: Design optimal peptide antigens:
-
- Solute carrier family 44 member 2 (CTL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IWA5- Family:
-
- Belongs to the CTL (choline transporter-like) family.
Function for SLC44A2 Gene
Molecular function for SLC44A2 Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1, but not isoform 3, exhibits some choline transporter activity.
Phenotypes From GWAS Catalog for SLC44A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015220 | choline transmembrane transporter activity | IDA,TAS | 10677542 |
| GO:0022857 | transmembrane transporter activity | IBA | 21873635 |
Phenotypes for SLC44A2 Gene
- MGI mutant phenotypes for SLC44A2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SLC44A2:
Animal Models for SLC44A2 Gene
- MGI Knock Outs for SLC44A2:
-
- Slc44a2 Slc44a2<tm1.2Tec>
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC44A2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC44A2 - Select products 50% OFF >
- * SLC44A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC44A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC44A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC44A2
miRNA for SLC44A2 Gene
- miRTarBase miRNAs that target SLC44A2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC44A2
- Browse OriGene Inhibitory RNA Products For SLC44A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC44A2
Clone Products
- Applied Biological Materials (abm): Clones for SLC44A2 - Select products 50% OFF >
- * SLC44A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210166
- MR210166
- MR210166L3
- MR210166L4
- MR230936
- RC207181
- RC207181L1
- RC207181L2
- RC207181L3
- RC207181L4
- RC227729
- RC227729L3
- RC227729L4
- RG207181
- RG227729
- RR215334
- RR215334L3
- RR215334L4
- MR210166L3V
- MR210166L4V
- RC207181L1V
- RC207181L2V
- RC207181L3V
- RC207181L4V
- RC227729L3V
- RC227729L4V
- RR215334L3V
- RR215334L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC44A2
- Addgene plasmids for SLC44A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC44A2
Cell Line Products
-
Horizon Cell Lines for SLC44A2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC44A2 Gene
Localization for SLC44A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC44A2 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| mitochondrion | 4 |
| lysosome | 4 |
| cytoskeleton | 3 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Cell Junctions (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA | 26746385 |
| GO:0005765 | lysosomal membrane | HDA | 17897319 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA,IBA | 21873635 |
| GO:0016021 | integral component of membrane | IEA,TAS | 10677542 |
Pathways & Interactions for SLC44A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 3 | Glycerophospholipid biosynthesis | ||
| 4 | Metabolism |
.40
|
|
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for SLC44A2 Gene
11 Reactome pathways for SLC44A2 Gene
1 KEGG pathway for SLC44A2 Gene
Interacting Proteins for SLC44A2 Gene
GPS-Prot Interaction Network for SLC44A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006656 | phosphatidylcholine biosynthetic process | TAS | -- |
| GO:0015871 | choline transport | IDA,TAS | 10677542 |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | HMP | 12761501 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0055085 | transmembrane transport | IDA,TAS | -- |
Drugs & Compounds for SLC44A2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Choline | Approved | Nutra | Transporter, substrate | 223 |
Transcripts for SLC44A2 Gene
mRNA/cDNA for SLC44A2 Gene
- 3 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000335757 3374 nts (view in UCSC)
- ENST00000407327 3301 nts (view in UCSC)
- ENST00000586078 3784 nts (view in UCSC)
- ENST00000586549 1300 nts (view in UCSC)
- ENST00000588214 598 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC44A2 - Select products 50% OFF >
- * SLC44A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC44A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC44A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC44A2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC44A2
- Browse OriGene Inhibitory RNA Products For SLC44A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC44A2
Clone Products
- Applied Biological Materials (abm): Clones for SLC44A2 - Select products 50% OFF >
- * SLC44A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210166
- MR210166
- MR210166L3
- MR210166L4
- MR230936
- RC207181
- RC207181L1
- RC207181L2
- RC207181L3
- RC207181L4
- RC227729
- RC227729L3
- RC227729L4
- RG207181
- RG227729
- RR215334
- RR215334L3
- RR215334L4
- MR210166L3V
- MR210166L4V
- RC207181L1V
- RC207181L2V
- RC207181L3V
- RC207181L4V
- RC227729L3V
- RC227729L4V
- RR215334L3V
- RR215334L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC44A2
- Addgene plasmids for SLC44A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC44A2
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 16d | · | 16e | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: |
Relevant External Links for SLC44A2 Gene
- GeneLoc Exon Structure for
- SLC44A2
Expression for SLC44A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Brain (Nervous System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for SLC44A2 Gene
This gene is overexpressed in Whole Blood (x4.8).
This gene is overexpressed in Nasal epithelium (43.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC44A2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC44A2
SOURCE GeneReport for Unigene cluster for SLC44A2 Gene:
Hs.534560mRNA Expression by UniProt/SwissProt for SLC44A2 Gene:
Q8IWA5-CTL2_HUMAN
Tissue specificity:
Present in supporting cells of the inner ear (at protein level). Only isoform 3 is expressed in inner ear vestibular tissue.
Evidence on tissue expression from TISSUES for SLC44A2 Gene
- Nervous system(5)
- Stomach(4.5)
- Lung(4.4)
- Liver(4.4)
- Eye(4.4)
- Kidney(3.5)
- Intestine(3.2)
- Muscle(3)
- Skin(2.7)
- Heart(2.6)
- Blood(2.6)
- Spleen(2.6)
- Lymph node(2.4)
Primer Products
-
OriGene qPCR primer pairs for SLC44A2
-
OriGene qPCR primer pairs and template standards for SLC44A2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC44A2 Gene
Orthologs for SLC44A2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC44A2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC44A2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC44A2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC44A2 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc44a2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc44a2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC44A2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC44A2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC44A2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc44a2 30 |
|
||
| Str.7588 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | slc44a2 30 31 |
|
OneToMany | |
| SLC44A2 (1 of 2) 31 |
|
OneToMany | |||
| sbcb39 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10852 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG11880 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | chtl-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PNS1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G15380 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0681600 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12838 30 |
|
- Species where no ortholog for SLC44A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC44A2 Gene
- ENSEMBL:
- Gene Tree for SLC44A2 (if available)
- TreeFam:
- Gene Tree for SLC44A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC44A2: view image
Paralogs for SLC44A2 Gene
(4) SIMAP similar genes for SLC44A2 Gene using alignment to 8 proteins:
- CTL2_HUMAN
- K7EKB7_HUMAN
- K7EMN3_HUMAN
- K7EMR2_HUMAN
- K7EPV6_HUMAN
- K7ER17_HUMAN
- K7ESF5_HUMAN
- K7ESP7_HUMAN
Variants for SLC44A2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1071907 | CNV | deletion | 25765185 |
| nsv1127651 | CNV | deletion | 24896259 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv833744 | CNV | loss | 17160897 |
| nsv833745 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.44;
42.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC44A2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC44A2 Gene
Disorders for SLC44A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| femoral vein thrombophlebitis |
|
|
| deafness, autosomal recessive 68 |
|
|
| meniere disease |
|
|
| choline deficiency disease |
|
|
| coffin-siris syndrome 1 |
|
|
Search SLC44A2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC44A2
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC44A2 Gene
Publications for SLC44A2 Gene
- Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear. (PMID: 17926100) Kommareddi PK … Carey TE (Journal of the Association for Research in Otolaryngology : JARO 2007) 3 4 23
- Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. (PMID: 14973250) Nair TS … Carey TE (The Journal of neuroscience : the official journal of the Society for Neuroscience 2004) 3 4 23
- An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. (PMID: 10677542) O'Regan S … Meunier FM (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4
- Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2. (PMID: 20665236) Kommareddi PK … Carey TE (The protein journal 2010) 3 4
- Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. (PMID: 20410607) Nakamura T … Tamai I (Biological & pharmaceutical bulletin 2010) 3 23
ExternalLinks
Products for SLC44A2 Gene
- Custom Antibody ServicesOriGene Antibodies for SLC44A2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SLC44A2
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC44A2
- Origene Custom Protein Services for SLC44A2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC44A2
- Browse OriGene Inhibitory RNA Products For SLC44A2
- OriGene qPCR primer pairs for SLC44A2
- OriGene qPCR primer pairs and template standards for SLC44A2
- OriGene CRISPR knockouts for SLC44A2
- MG210166
- MR210166
- MR210166L3
- MR210166L4
- MR230936
- RC207181
- RC207181L1
- RC207181L2
- RC207181L3
- RC207181L4
- RC227729
- RC227729L3
- RC227729L4
- RG207181
- RG227729
- RR215334
- RR215334L3
- RR215334L4
- MR210166L3V
- MR210166L4V
- RC207181L1V
- RC207181L2V
- RC207181L3V
- RC207181L4V
- RC227729L3V
- RC227729L4V
- RR215334L3V
- RR215334L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC44A2
- Sino Biological Human cDNA Clone for SLC44A2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SLC44A2
- Novus Biologicals proteins and lysates for SLC44A2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SLC44A2
- Abcam proteins for SLC44A2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SLC44A2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SLC44A2 (AFLGC-SLC44A2)
- VectorBuilder Custom and pre-made DNA vectors for SLC44A2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SLC44A2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SLC44A2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SLC44A2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SLC44A2
- Addgene plasmids for SLC44A2
- antibodies-online: Show 10 available SLC44A2 Antibodies ranked by validation data
- Compare Top SLC44A2 Antibodies
- antibodies-online: Search results for available SLC44A2 related products ranked by validation data
- antibodies-online: Show 6 available SLC44A2 Proteins ranked by validation data
- Compare Top SLC44A2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SLC44A2
- Search Santa Cruz Biotechnology (SCBT) for SLC44A2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC44A2
- Horizon Cell Lines for SLC44A2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC44A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC44A2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SLC44A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC44A2
Sources for SLC44A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB