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This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided b... See more...
Aliases for SLC43A2 Gene
Aliases for SLC43A2 Gene
External Ids for SLC43A2 Gene
- HGNC: 23087
- Entrez Gene: 124935
- Ensembl: ENSG00000167703
- OMIM: 610791
- UniProtKB: Q8N370
Previous GeneCards Identifiers for SLC43A2 Gene
- GC17M001426
- GC17M001477
- GC17M001472
Summaries for SLC43A2 Gene
-
This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]
GeneCards Summary for SLC43A2 Gene
SLC43A2 (Solute Carrier Family 43 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Amino acid transport across the plasma membrane. Gene Ontology (GO) annotations related to this gene include L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC43A1.
UniProtKB/Swiss-Prot Summary for SLC43A2 Gene
-
Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.
Additional gene information for SLC43A2 Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC43A2 Gene
Genomics for SLC43A2 Gene
GeneHancer (GH) Regulatory Elements for SLC43A2 Gene
Promoters and enhancers for SLC43A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC43A2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLC43A2 gene promoter:
-
- AhR
- AML1a
- Arnt
- c-Ets-1
- Elk-1
- GATA-2
- HEN1
- STAT1
Genomic Locations for SLC43A2 Gene
Genomic Locations for SLC43A2 Gene
- chr17:1,569,254-1,630,018
- (GRCh38/hg38)
- Size:
- 60,765 bases
- Orientation:
- Minus strand
- chr17:1,472,561-1,532,180
- (GRCh37/hg19)
- Size:
- 59,620 bases
- Orientation:
- Minus strand
Genomic View for SLC43A2 Gene
Genes around SLC43A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by HGNC
- 17p13.3 by Entrez Gene
- 17p13.3 by Ensembl
SLC43A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC43A2 Gene
Proteins for SLC43A2 Gene
-
Protein details for SLC43A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N370-LAT4_HUMAN
- Recommended name:
- Large neutral amino acids transporter small subunit 4
- Protein Accession:
- Q8N370
- B7Z6X9
- C9JNU8
- D3DTH9
- Q5CD75
- Q6IPM1
- Q8NBX1
- Q8NC21
- Q8WZ00
Protein attributes for SLC43A2 Gene
- Size:
- 569 amino acids
- Molecular mass:
- 62747 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC11383.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11450.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SLC43A2 Gene
Post-translational modifications for SLC43A2 Gene
- Glycosylated.
-
Glycosylation at Asn55, Asn58, and Asn560
- NX_Q8N370 (NX_Q8N370-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SLC43A2 Gene
Antibody Products
- Atlas Antibodies Anti-SLC43A2 Antibody
- Creative Diagnostics Anti-SLC43A2 polyclonal antibody and Anti-SLC43A2 (aa 243-273) polyclonal antibody
- Novus Biologicals Antibodies for SLC43A2
-
Abcam antibodies for SLC43A2
- Invitrogen Antibodies for SLC43A2 (AFLGC-SLC43A2)
Protein Products
- Atlas Antibodies PrEST Antigen SLC43A2
- Creative Biomart Recombinant Human SLC43A2 293 Cell Lysate
-
OriGene Purified Proteins for SLC43A2
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC43A2
- Origene Custom Protein Services for SLC43A2
- antibodies-online: Show 3 available SLC43A2 Proteins ranked by validation data
- Compare Top SLC43A2 Proteins
-
Quality Products:
-
Abcam proteins for SLC43A2
No data available for DME Specific Peptides for SLC43A2 Gene
Domains & Families for SLC43A2 Gene
Gene Families for SLC43A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC43A2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC43A2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55865, highly similar to Homo sapiens solute carrier family 43, member 2 (SLC43A2), mRNA (B7Z6X9_HUMAN)
- Solute carrier family 43 member 2 (LAT4_HUMAN)
- SLC43A2 protein (Q8WUU1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N370- Family:
-
- Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Function for SLC43A2 Gene
Molecular function for SLC43A2 Gene
- UniProtKB/Swiss-Prot Function:
- Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.
Phenotypes From GWAS Catalog for SLC43A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015171 | amino acid transmembrane transporter activity | TAS | -- |
| GO:0015175 | neutral amino acid transmembrane transporter activity | IBA | 21873635 |
| GO:0015179 | L-amino acid transmembrane transporter activity | IEA,IBA | 21873635 |
Phenotypes for SLC43A2 Gene
- MGI mutant phenotypes for SLC43A2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC43A2:
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC43A2
CRISPR Products
-
OriGene CRISPR knockouts for SLC43A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC43A2
- genomics-online: gRNA clones - Search results for available SLC43A2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for SLC43A2 - Select products 50% OFF >
- * SLC43A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC43A2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC43A2
miRNA for SLC43A2 Gene
- miRTarBase miRNAs that target SLC43A2
-
- hsa-mir-5008-5p (MIRT530754)
- hsa-mir-4258 (MIRT530755)
- hsa-mir-4257 (MIRT530756)
- hsa-mir-4279 (MIRT634316)
- hsa-mir-377-3p (MIRT634317)
- hsa-mir-6778-3p (MIRT634318)
- hsa-mir-1976 (MIRT634319)
- hsa-mir-3653-5p (MIRT634320)
- hsa-mir-1281 (MIRT634321)
- hsa-mir-6747-3p (MIRT634322)
- hsa-mir-6727-3p (MIRT634323)
- hsa-mir-4722-3p (MIRT634324)
- hsa-mir-4485-5p (MIRT634325)
- hsa-mir-4532 (MIRT634326)
- hsa-mir-1247-3p (MIRT634327)
- hsa-mir-1228-3p (MIRT634328)
- hsa-mir-4284 (MIRT653478)
- hsa-mir-2276-3p (MIRT653479)
- hsa-mir-4638-5p (MIRT653480)
- hsa-mir-1307-3p (MIRT653481)
- hsa-mir-6741-3p (MIRT653482)
- hsa-mir-6890-3p (MIRT653483)
- hsa-mir-3680-3p (MIRT653484)
- hsa-mir-557 (MIRT653485)
- hsa-mir-507 (MIRT653486)
- hsa-mir-450b-5p (MIRT653487)
- hsa-mir-6516-5p (MIRT653488)
- hsa-mir-1238-3p (MIRT653489)
- hsa-mir-3678-3p (MIRT653490)
- hsa-mir-1273h-3p (MIRT653491)
- hsa-mir-6749-3p (MIRT653492)
- hsa-mir-6792-3p (MIRT653493)
- hsa-mir-4691-5p (MIRT653494)
- hsa-mir-211-5p (MIRT653495)
- hsa-mir-204-5p (MIRT653496)
- hsa-mir-3124-3p (MIRT653497)
- hsa-mir-4685-3p (MIRT653498)
- hsa-mir-4287 (MIRT653499)
- hsa-mir-4303 (MIRT653500)
- hsa-mir-6832-3p (MIRT653501)
- hsa-mir-6770-5p (MIRT653502)
- hsa-mir-3182 (MIRT653503)
- hsa-mir-1253 (MIRT653504)
- hsa-mir-6761-5p (MIRT653505)
- hsa-mir-4329 (MIRT653506)
- hsa-mir-4251 (MIRT653507)
- hsa-mir-7110-3p (MIRT653508)
- hsa-mir-6845-3p (MIRT653509)
- hsa-mir-877-3p (MIRT653510)
- hsa-mir-1343-3p (MIRT737438)
- hsa-mir-139-3p (MIRT737552)
- hsa-mir-493-3p (MIRT749251)
- hsa-mir-5091 (MIRT749661)
- hsa-mir-564 (MIRT751110)
- hsa-mir-6742-3p (MIRT754367)
- hsa-mir-6783-3p (MIRT755735)
- hsa-mir-6852-5p (MIRT757651)
- hsa-mir-939-3p (MIRT760728)
- hsa-mir-1304-3p (MIRT762430)
- hsa-mir-150-5p (MIRT762874)
- hsa-mir-3199 (MIRT765510)
- hsa-mir-365a-5p (MIRT766438)
- hsa-mir-365b-5p (MIRT766447)
- hsa-mir-4438 (MIRT769136)
- hsa-mir-5095 (MIRT773288)
- hsa-mir-562 (MIRT774904)
- hsa-mir-5697 (MIRT775124)
- hsa-mir-6814-5p (MIRT779801)
- hsa-mir-7151-3p (MIRT781519)
- hsa-mir-8052 (MIRT782300)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SLC43A2
- Browse OriGene Inhibitory RNA Products For SLC43A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC43A2
- genomics-online: shRNA clones - Search results for available SLC43A2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SLC43A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC43A2
- genomics-online: cdna clones - Search results for available SLC43A2 gene related products
- orf clones - Search results for available SLC43A2 gene related products
- Applied Biological Materials (abm): Clones for SLC43A2 - Select products 50% OFF >
- * SLC43A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC43A2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for SLC43A2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC43A2 Gene
Localization for SLC43A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC43A2 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC43A2 Gene
Pathways & Interactions for SLC43A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 2 | Amino acid transport across the plasma membrane | ||
Pathways by source for SLC43A2 Gene
Interacting Proteins for SLC43A2 Gene
GPS-Prot Interaction Network for SLC43A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006865 | amino acid transport | TAS | -- |
| GO:0015804 | neutral amino acid transport | IBA | 21873635 |
| GO:0015807 | L-amino acid transport | IEA | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
| GO:1902475 | L-alpha-amino acid transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC43A2 Gene
Drugs & Compounds for SLC43A2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Chloride ion | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sodium |
|
7440-23-5 |
|
Drug Products
- Atlas Antibodies PrEST Antigen SLC43A2
- Creative Biomart Recombinant Human SLC43A2 293 Cell Lysate
Transcripts for SLC43A2 Gene
mRNA/cDNA for SLC43A2 Gene
- (5) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (143) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000301335 8136 bps (ENST00000301335.9)
- ENST00000412517 1658 bps (ENST00000412517.3)
- ENST00000571376 623 bps (ENST00000571376.1)
- ENST00000571650 3261 bps (ENST00000571650.5)
- ENST00000572135 2074 bps (ENST00000572135.5)
CRISPR Products
-
OriGene CRISPR knockouts for SLC43A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC43A2
- genomics-online: gRNA clones - Search results for available SLC43A2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for SLC43A2 - Select products 50% OFF >
- * SLC43A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC43A2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC43A2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SLC43A2
- Browse OriGene Inhibitory RNA Products For SLC43A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC43A2
- genomics-online: shRNA clones - Search results for available SLC43A2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SLC43A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC43A2
- genomics-online: cdna clones - Search results for available SLC43A2 gene related products
- orf clones - Search results for available SLC43A2 gene related products
- Applied Biological Materials (abm): Clones for SLC43A2 - Select products 50% OFF >
- * SLC43A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC43A2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | - | ||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | - | - | |||||||||||||||||
| SP10: | - | ||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: | |||||||||||||||||||
| SP14: |
Expression for SLC43A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Loop of Henle Cells Loop of Henle
- Loop of Henle
- Intestine (Gastrointestinal Tract)
-
Epithelial Cells
- Loop of Henle Cells Loop of Henle
- Brain (Nervous System)
- Ovary (Reproductive System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for SLC43A2 Gene
This gene is overexpressed in Whole Blood (x12.7) and Muscle - Skeletal (x4.6).
This gene is overexpressed in Liver (42.4) and Placenta (9.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC43A2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC43A2 Gene:
SLC43A2SOURCE GeneReport for Unigene cluster for SLC43A2 Gene:
Hs.160550mRNA Expression by UniProt/SwissProt for SLC43A2 Gene:
Q8N370-LAT4_HUMAN
Tissue specificity:
Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus.
Evidence on tissue expression from TISSUES for SLC43A2 Gene
- Spleen(4.3)
- Nervous system(4.3)
- Kidney(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for SLC43A2
-
OriGene qPCR primer pairs and template standards for SLC43A2
- genomics-online: primer clones - Search results for available SLC43A2 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC43A2 Gene
Orthologs for SLC43A2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC43A2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SLC43A2 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SLC43A2 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Slc43a2 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc43a2 17 33 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC43A2 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SLC43A2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC43A2 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SLC43A2 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc43a2 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5041 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | slc43a2a 33 |
|
OneToMany | |
| slc43a2b 33 32 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11109 32 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for SLC43A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SLC43A2 Gene
- ENSEMBL:
- Gene Tree for SLC43A2 (if available)
- TreeFam:
- Gene Tree for SLC43A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC43A2: view image
Paralogs for SLC43A2 Gene
Variants for SLC43A2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000094947 | -- | 1,571,484(-) | C/T | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000150770 | -- | 1,610,013(-) | G/A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000200876 | -- | 1,605,816(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000246095 | -- | 1,609,560(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000320136 | -- | 1,576,449(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1004030 | CNV | deletion | 20482838 |
| esv2660696 | CNV | deletion | 23128226 |
| esv2670177 | CNV | deletion | 23128226 |
| esv2715472 | CNV | deletion | 23290073 |
| esv2715475 | CNV | deletion | 23290073 |
| esv2715476 | CNV | deletion | 23290073 |
| esv2715477 | CNV | deletion | 23290073 |
| esv3639690 | CNV | loss | 21293372 |
| esv3639691 | CNV | loss | 21293372 |
| esv3639692 | CNV | loss | 21293372 |
| nsv1134585 | CNV | deletion | 24896259 |
| nsv1945 | CNV | insertion | 18451855 |
| nsv457635 | CNV | gain | 19166990 |
| nsv516055 | CNV | gain+loss | 19592680 |
| nsv527897 | CNV | loss | 19592680 |
| nsv574211 | CNV | gain | 21841781 |
| nsv833334 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.54;
29.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC43A2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC43A2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC43A2 Gene
Disorders for SLC43A2 Gene
Additional Disease Information for SLC43A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SLC43A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC43A2 Gene
Publications for SLC43A2 Gene
- The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. (PMID: 23268354) Bodoy S … Palacín M (Molecular aspects of medicine 2013) 2 3 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
- Identification of LAT4, a novel amino acid transporter with system L activity. (PMID: 15659399) Bodoy S … Bertran J (The Journal of biological chemistry 2005) 3 4 56
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
ExternalLinks
Products for SLC43A2 Gene
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Sources for SLC43A2 Gene
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